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IQ 3是一种选择性JNK3抑制剂（JNK3，JNK1和JNK2的Kd值分别为66、240和290 nM）。抑制THP1-Blue细胞中的NF-kB/AP1转录活性（IC50 = 1.4μM）。在体外也抑制TNF-α和IL-6的产生。
| In vitro | DMSO | 9 mg/mL (26.36 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 29.3 mL | 146.49 mL | 292.98 mL |
| 0.5 mM | 5.86 mL | 29.3 mL | 58.6 mL |
| 1 mM | 2.93 mL | 14.65 mL | 29.3 mL |
| 5 mM | 0.59 mL | 2.93 mL | 5.86 mL |
*The above data is based on the productmolecular weight 341.32. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A16036 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 341.32 |
| Formula | C20H11N3O3 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 312538-03-7 |
| Synonyms | IQ3, IQ-3 |
| SMILES | C1=CC=C2C(=C1)C3=NC4=CC=CC=C4N=C3C2=NOC(=O)C5=CC=CO5 |
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