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ISRIB (trans-isomer)是一种有效的选择性小分子PERK信号抑制剂（IC50?5 nM），可以有效逆转eIF2α磷酸化的作用。
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 22.16 mL | 110.78 mL | 221.56 mL |
| 0.5 mM | 4.43 mL | 22.16 mL | 44.31 mL |
| 1 mM | 2.22 mL | 11.08 mL | 22.16 mL |
| 5 mM | 0.44 mL | 2.22 mL | 4.43 mL |
*The above data is based on the productmolecular weight 451.34. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A13816 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 451.34 |
| Formula | C22H24Cl2N2O4 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| SMILES | O=C(N[C@@H]1CC[C@@H](NC(COC2=CC=C(Cl)C=C2)=O)CC1)COC3=CC=C(Cl)C=C3 |
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