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ITI-214 is a picomolar PDE1 inhibitor with excellent selectivity against other PDE family members and against a panel of enzymes, receptors, transporters, and ion channels, exhibits potent PDE1 inhibitory activity (Ki = 58 pM).
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 16.51 mL | 82.57 mL | 165.14 mL |
| 0.5 mM | 3.3 mL | 16.51 mL | 33.03 mL |
| 1 mM | 1.65 mL | 8.26 mL | 16.51 mL |
| 5 mM | 0.33 mL | 1.65 mL | 3.3 mL |
*The above data is based on the productmolecular weight 605.56. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A21422 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 605.56 |
| Formula | C29H29FN7O5P |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1642303-38-5 |
| Synonyms | ITI 214, ITI-214 |
| SMILES | O=C(C1=C(NC2=CC=CC=C2)N(CC3=CC=C(C4=NC(F)=CC=C4)C=C3)N=C1N56)N(C)C5=N[C@@]7([H])[C@]6([H])CCC7.O=P(O)(O)O |
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