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JAK-IN-3 (compound 22) is a potent JAK inhibitor, with IC50 values of 3 nM, 5 nM, 34 nM and 70 nM for JAK3, JAK1, TYK2 and JAK2, respectively.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 29.38 mL | 146.89 mL | 293.79 mL |
| 0.5 mM | 5.88 mL | 29.38 mL | 58.76 mL |
| 1 mM | 2.94 mL | 14.69 mL | 29.38 mL |
| 5 mM | 0.59 mL | 2.94 mL | 5.88 mL |
*The above data is based on the productmolecular weight 340.38. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A20220 |
|---|---|
| M. Wt | 340.38 |
| Formula | C18H20N4O3 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1400876-94-9 |
| SMILES | O=C(C1=C(N[C@@H]([C@H](O)C)CO)C2=CC(C3=CC=CC=C3)=CN2N=C1)N |
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