JAK / Stat

产品 51 到 100 共 209个

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  1. Baricitinib phosphate

    Catalog No. A15014
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    JAK 抑制剂
    Baricitinib phosphate是一种选择性的JAK1和JAK2抑制剂,IC50为5.9 nM和5.7 nM,选择性是JAK3和Tyk2的?70和?10倍,对c-Met和Chk2没有抑制作用。 了解更多
  2. CHZ868

    Catalog No. A15937
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    JAK2 抑制剂
    CHZ868是一种有效的选择性II型JAK抑制剂,在JAK抑制剂持续性细胞,鼠类MPN模型和MPN患者样品中显示出活性。 了解更多
  3. SB1317 (TG02)

    Catalog No. A13454
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    CDK/JAK2/FLT3 抑制剂
    SB1317是细胞周期蛋白依赖性激酶(CDKs)、类FMS酪氨酸激酶-3(FLT3)和Janus激酶2(JAK2)的有效抑制剂,CDK2、JAK2和FLT3的IC50值分别为13nM、56nM和73nM。 了解更多
  4. FM-381

    Catalog No. A16805
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    JAK3 抑制剂
    FM-381是一种JAK3特异性可逆共价抑制剂,对JAK3的IC50为127 pM,相对于JAK1,JAK2和TYK2分别具有400、2、700和3,600倍的选择性。 了解更多
  5. PF-06651600

    Catalog No. A16803
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    JAK3 抑制剂
    PF-06651600是一种有效且不可逆的JAK3选择性抑制剂,IC50为33.1 nM,但对JAK1,JAK2和TYK2没有活性(IC50> 10 000 nM)。 了解更多
  6. Ruxolitinib Phosphate

    Catalog No. A11552
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    JAK 抑制剂
    Ruxolitinib Phosphate是ruxolitinib的磷酸盐形式,ruxolitinib是一种口服生物可利用的Janus相关激酶(JAK)抑制剂,具有潜在的抗肿瘤和免疫调节活性。 了解更多
  7. PF-06700841 tosylate

    Catalog No. A17176
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    JAK1 and TYK2 抑制剂
    PF-06700841 tosylate是JAK1和TYK2激酶的抑制剂。 了解更多
  8. JAK3-IN-2

    Catalog No. A18323
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    JAK3 抑制剂
    JAK3-IN-2 is a potent and highly selective JAK3 inhibitor with IC50 of 0.15 nM. dispalys >4,300-fold selectivity over JAK1, JAK2 and TYK2, and other kinases BMX, EGFR, ITK and BTK; blocks cytokine signaling through JAK3, but not through other JAK family enzymes; inhibits IL-7 induced pSTAT5 in CD3+, CD8+ T cells with IC50 of 280 nM; sufficiently blocks the development of inflammation in a rat model of rheumatoid arthritis, while sparing hematopoiesis. 了解更多
  9. Abrocitinib (PF-04965842)

    Catalog No. A18318
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    JAK1 抑制剂
    Abrocitinib (PF-04965842) is a potent, orally active and selective JAK1 inhibitor, with IC50s of 29 and 803 nM for JAK1 and JAK2, respectively. Abrocitinib (PF-04965842) exhibits less active effect on TYK2 (IC50, 1.253 μM), and inhibits phosphorylation of STAT1, STAT3 and STAT5 after stimulation. Effective in autoimmune disease. 了解更多
  10. WHI-P258

    Catalog No. A18317
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    JAK3 抑制剂
    WHI-P258 is a quinazoline compound that modeling studies suggested would bind to the active site of JAK3 with an estimated Ki value of 72 uM. 了解更多
  11. Upadacitinib (ABT-494)

    Catalog No. A18316
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    JAK-1 抑制剂
    Upadacitinib (ABT-494) is a potent and selective Janus kinase (JAK) 1 inhibitor being developed for the treatment of several autoimmune disorders with an IC50 of 43 nM. IC50 & Target: IC50: 43 nM (JAK1), 200 nM (JAK2) 了解更多
  12. BMS-986165

    Catalog No. A18726
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    TYK2 抑制剂
    BMS-986165 is a Highly Potent and Selective Allosteric Inhibitor of TYK2. BMS-986165 Blocks Il-12, IL-23 and type I Interferon Signaling and Provides for Robust Efficacy in Preclinical Models of Inflammatory Bowel Disease. 了解更多
  13. Tyk2-IN-8

    Catalog No. A19052
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    TYK2 抑制剂
    Tyk2-IN-8 (compound 10) is a selective TYK2 inhibitor, which binds to TYK2 catalytically active JH1 domain with an IC50 of 17 nM, used in the treatment of psoriasis. 了解更多
  14. JAK1-IN-7

    Catalog No. A19029
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    JAK1 抑制剂
    JAK1-IN-7 is a Janus-associated kinase 1 (JAK1) inhibitor extracted from patent WO2018134213A1, Example 63, has an anti-inflammatory effect. 了解更多
  15. JAK3 covalent inhibitor-1

    Catalog No. A18926
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    JAK3 covalent 抑制剂
    JAK3 covalent inhibitor-1 is a potent and selective janus kinase 3 (JAK3) covalent inhibitor with an IC50 of 11 nM and shows 246-fold selectivity vs other JAKs. 了解更多
  16. JAK1-IN-4

    Catalog No. A18821
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    JAK1 抑制剂
    JAK1-IN-4 is a potent and selective JAK1 inhibitor, with IC50s of 85 nM, 12.8 μM and >30 μM for JAK1, JAK2, and JAK3, respectively. JAK1-IN-4 inhibits STAT3 phosphorylation in NCI-H 1975 cells (IC50, 227 nM). 了解更多
  17. Tofacitinib

    Catalog No. A17252
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    JAK3/2/1 inhibitor
    Tofacitinib is an orally available JAK3/2/1 inhibitor with IC50s of 1, 20, and 112 nM, respectively. 了解更多
  18. PF-06263276

    Catalog No. A12572
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    pan-JAK inhibitor
    PF-06263276 (PF 6263276) is a potent and selective pan-JAK inhibitor, with IC50s of 2.2 nM, 23.1 nM, 59.9 nM and 29.7 nM for JAK1, JAK2, JAK3 and TYK2, respectively. 了解更多
  19. Ruxolitinib sulfate

    Catalog No. A11467
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    JAK1/2 inhibitor
    Ruxolitinib sulfate (INCB018424 sulfate) is the first potent, selective JAK1/2 inhibitor to enter the clinic with IC50s of 3.3 nM/2.8 nM, and has > 130-fold selectivity for JAK1/2 versus JAK3. 了解更多
  20. JAK2-IN-4

    Catalog No. A12182
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    JAK2/JAK3 inhibitor
    JAK2-IN-4 (compound 16h) is a selective JAK2/JAK3 inhibitor, with IC50 values of 0.7 nM and 23.2 nM for JAK2 and JAK3, respectively. 了解更多
  21. JAK/HDAC-IN-1

    Catalog No. A13362
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    JAK2/HDAC dual inhibitor
    JAK/HDAC-IN-1 is a potent JAK2/HDAC dual inhibitor, exhibits antiproliferative and proapoptotic activities in several hematological cell lines. 了解更多
  22. Oclacitinib maleate

    Catalog No. A16640
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    JAK inhibitor
    Oclacitinib maleate (PF-03394197 maleate) is a novel JAK inhibitor. Oclacitinib maleate (PF-03394197 maleate) is most potent at inhibiting JAK1 (IC50=10 nM). 了解更多
  23. JAK-IN-1

    Catalog No. A21237
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    JAK1/2/3 inhibitor
    JAK-IN-1 is a JAK1/2/3 inhibitor with IC50s of 0.26, 0.8 and 3.2 nM, respectively. JAK-IN-1 shows improved selectivity for JAK3 over JAK1. 了解更多
  24. NVP-BSK805 dihydrochloride

    Catalog No. A21406
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    JAK2 inhibitor
    NVP-BSK805 dihydrochloride (BSK805 dihydrochloride) is an ATP-competitive JAK2 inhibitor, with IC50s of 0.48 nM, 31.63 nM, 18.68 nM, and 10.76 nM for JAK2 JH1 (JAK homology 1), JAK1 JH1, JAK3 JH1, and TYK2 JH1, respectively. 了解更多
  25. Tyk2-IN-7

    Catalog No. A21491
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    TYK2 JH2 inhibitor
    Tyk2-IN-7 (Compound 48) is a TYK2 JH2 inhibitor, binds to TYK2 JH2 domain with IC50 and Ki.app of 0.00053 μM and 0.00007 μM, respectively. 了解更多
  26. PF-06700841 P-Tosylate

    Catalog No. A21652
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    dual JAK1/TYK2 inhibitor
    PF-06700841 P-Tosylate is a potent dual Janus kinase 1 (JAK1) and TYK2 inhibitor with IC50s of 17 nM and 23 nM, respectively. 了解更多
  27. Momelotinib Mesylate

    Catalog No. A21658
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    JAK1/JAK2 inhibitor
    Momelotinib Mesylate (CYT387 Mesylate) is an ATP-competitive inhibitor of JAK1/JAK2 with IC50 of 11 nM/18 nM, appr 10-fold selectivity versus JAK3. 了解更多
  28. BMS-066

    Catalog No. A21972
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    IKKβ/Tyk2 pseudokinase inhibitor
    BMS-066 is an IKKβ/Tyk2 pseudokinase inhibitor, with IC50s of 9 nM and 72 nM, respectively. 了解更多
  29. Tyk2-IN-3

    Catalog No. A21982
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    Tyk2 pseudokinase inhibitor
    Tyk2-IN-3 is a Tyk2 pseudokinase inhibitor, with an IC50 of 485 nM. 了解更多
  30. Nitidine chloride

    Catalog No. A14701
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    STAT 抑制剂
    Nitidine chloride是一种天然的苯并菲啶生物碱,已显示出通过诱导细胞凋亡和抑制癌血管生成来抑制癌症的生长。 了解更多
  31. STA-21

    Catalog No. A15885
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    STAT-3 抑制剂
    STA-21是一种有前途的STAT-3抑制剂,可在类风湿关节炎的实验模型中相互调节Th17和Treg细胞,抑制小鼠和人类的破骨细胞生成并减轻自身免疫炎症。 了解更多
  32. Corylifol A

    Catalog No. A15729
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    STAT3 抑制剂
    Corylifol A是一种从补骨脂中分离出来的酚类化合物。抑制IL-6诱导的STAT3活化和磷酸化(IC50 = 0.8 uM)。 了解更多
  33. Nifuroxazide

    Catalog No. A16220
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    STAT 抑制剂
    Nifuroxazide是STAT激活和信号传导活性的抑制剂,是一种口服硝基呋喃抗生素,用于治疗人类和非人类的结肠炎和腹泻。 了解更多
  34. S3I-201 (NSC 74859)

    Catalog No. A10817
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    Stat3 抑制剂
    S3I-201(NSC 74859)是Stat3的新型抑制剂,可在体外抑制Stat3,Stat3复合物的形成以及Stat3-DNA结合活性(IC50 = 86±33 ?M)和Stat3依赖性转录活性。 了解更多
  35. Artesunate

    Catalog No. A10087
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    cytochrome oxidase 抑制剂
    Artesunate是用于治疗疟疾的青蒿素的半合成衍生物。它也被证明可以有效对抗其他寄生虫,例如肝吸虫。青蒿琥酯还显示出针对不同肿瘤类型的癌细胞系的细胞毒性作用。青蒿琥酯已显示出通过抑制类风湿关节炎成纤维细胞样滑膜细胞中的NF-B和PI3激酶/ Akt信号通路来抑制TNF诱导的促炎细胞因子的产生。 了解更多
  36. Cryptotanshinone

    Catalog No. A10244
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    Stat3 抑制剂
    Cryptotanshinone是一种STAT3抑制剂,在DU145细胞中能显着阻断STAT3 Tyr705磷酸化,但不能阻断STAT3 Ser727磷酸化,并显着抑制JAK2磷酸化,IC50为?5μM,而不影响上游激酶c的磷酸化。 了解更多
  37. Fludarabine (Fludara)

    Catalog No. A10396
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    STAT 抑制剂
    Fludarabine或fludarabine(fludara)是一种用于治疗血液恶性肿瘤(血细胞癌,如白血病和淋巴瘤)的化疗药物。Fludarabine通过干扰核糖核苷酸还原酶和DNA聚合酶来抑制DNA合成。它对分裂细胞和静止细胞都有活性。 了解更多
  38. HO-3867

    Catalog No. A14264
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    STAT3 抑制剂
    HO-3867是一种选择性STAT3抑制剂。 了解更多
  39. SH-4-54

    Catalog No. A14249
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    Stat 抑制剂
    SH-4-54是一种有效的STAT抑制剂,对STAT3和STAT5的KD为300 nM和464 nM。 了解更多
  40. Stattic

    Catalog No. A12733
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    STAT3 抑制剂
    Stattic是第一个非肽类STAT3小分子抑制剂,有效抑制STAT3激活和核易位,IC50为5.1 μM,可通过阻断磷酸化和二聚化事件来选择性抑制Stat3转录因子的激活。 了解更多
  41. STAT5 Inhibitor

    Catalog No. A13628
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    STAT 抑制剂
    STAT5抑制剂是一种细胞可渗透的非肽烟酰yl,可通过靶向其SH2结构域(针对STAT5βSH2结构域EPO肽结合活性的IC50 = 47μM)来抑制STAT5。 了解更多
  42. Napabucasin

    Catalog No. A13474
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    STAT 抑制剂
    Napabucasin是一种口服小分子药物,它可以阻止癌症干细胞(CSC)自我更新,并诱导CSC和非干细胞中的细胞死亡。 了解更多
  43. HJC0152

    Catalog No. A16806
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    STAT3 抑制剂
    HJC0152是一种STAT3抑制剂,具有显着改善的水溶性。 了解更多
  44. C188-9

    Catalog No. A16804
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    STAT3 抑制剂
    C188-9是一种有效的STAT3抑制剂,它以高亲和力(KD = 4.7±0.4 nM)与STAT3结合。C188-9在小鼠中具有良好的耐受性,显示出良好的口服生物利用度,并且集中在肿瘤中。 了解更多
  45. AS-1517499

    Catalog No. A16802
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    STAT6 抑制剂
    AS1517499是一种新型有效的STAT6抑制剂,IC50值为21 nM。 了解更多
  46. AC-4-130

    Catalog No. A18314
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    STAT5 SH2 domain 抑制剂
    AC-4-130 is a novel, potent STAT5 SH2 domain inhibitor, binds to and efficiently blocks STAT5 activation and subsequent transcriptional activity, shows high selectivity for STAT5 over STAT1 and STAT3. 了解更多
  47. STAT3-IN-3

    Catalog No. A18479
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    STAT3 inhibitor
    STAT3-IN-3 is a potent and selective inhibitor of signal transducer and activator of transcription 3 (STAT3). 了解更多
  48. STAT3-IN-1

    Catalog No. A12232
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    STAT3 inhibitor
    STAT3-IN-1 (compound 7d) is an excellent, selective and orally active STAT3 inhibitor, with IC50 values of 1.82 μM and 2.14 μM in HT29 and MDA-MB 231 cells, respectively. STAT3-IN-1 (compound 7d) induces tumor apoptosis. 了解更多
  49. AZD1208

    Catalog No. A13203
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    pan-Pim kinase 抑制剂
    AZD1208是PIM激酶的小分子抑制剂,具有潜在的抗肿瘤活性。 了解更多
  50. SGI-1776 (free base)

    Catalog No. A10838
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    PIM1 抑制剂
    SGI-1776 (free base)是Pim1的一种新型ATP竞争性抑制剂,在无细胞试验中的IC50为7 nM,选择性是Pim2和Pim3的50倍和10倍,对Flt3和haspin也有效。阶段1。 了解更多

产品 51 到 100 共 209个

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