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JNJ-47117096 hydrochloride is potent and selective MELK inhibitor, with an IC50 of 23 nM, also effectively inhibits Flt3, with an IC50 of 18 nM.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 25.07 mL | 125.35 mL | 250.7 mL |
| 0.5 mM | 5.01 mL | 25.07 mL | 50.14 mL |
| 1 mM | 2.51 mL | 12.53 mL | 25.07 mL |
| 5 mM | 0.5 mL | 2.51 mL | 5.01 mL |
*The above data is based on the productmolecular weight 398.89. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A21542 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 398.89 |
| Formula | C21H23ClN4O2 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1610536-69-0 |
| Synonyms | MELK-T1 hydrochloride, JNJ47117096, JNJ 47117096 |
| SMILES | O=C(NC1=CC=C2CCNCCC2=C1)C3=CC=C(C4=CNN=C4)C=C3OC.Cl |
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