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JNJ-54175446 is a potent and selective brain penetrant P2X7 receptor antagonist, with pIC50s of 8.46 and 8.81 for hP2X7 receptor and rP2X7 receptor, respectively.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 22.69 mL | 113.44 mL | 226.87 mL |
| 0.5 mM | 4.54 mL | 22.69 mL | 45.37 mL |
| 1 mM | 2.27 mL | 11.34 mL | 22.69 mL |
| 5 mM | 0.45 mL | 2.27 mL | 4.54 mL |
*The above data is based on the productmolecular weight 440.78. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A18675 |
|---|---|
| 作用机制 | Antagonist (拮抗剂) |
| M. Wt | 440.78 |
| Formula | C18H13ClF4N6O |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1627902-21-9 |
| Synonyms | JNJ54175446, JNJ 54175446 |
| SMILES | ClC1=C(C=CC=C1C(N2CCC3=C(N=NN3C4=NC=C(F)C=N4)[C@H]2C)=O)C(F)(F)F |
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