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JW-642是有效的单酰基甘油脂肪酶（MAGL）抑制剂，对小鼠，大鼠和人脑膜的MAGL抑制作用的IC50值分别为7.6、14和3.7 nM。
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 21.63 mL | 108.13 mL | 216.26 mL |
| 0.5 mM | 4.33 mL | 21.63 mL | 43.25 mL |
| 1 mM | 2.16 mL | 10.81 mL | 21.63 mL |
| 5 mM | 0.43 mL | 2.16 mL | 4.33 mL |
*The above data is based on the productmolecular weight 462.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A13774 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 462.4 |
| Formula | C21H20F6N2O3 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1416133-89-5 |
| Synonyms | JW 642, JW642 |
| SMILES | O=C(OC(C(F)(F)F)C(F)(F)F)N1CCN(CC2=CC=CC(OC3=CC=CC=C3)=C2)CC1 |
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