JZL184

Name: JZL184
SKU: A12747

目录号: A12747

MAGL 抑制剂

Product Citations (4)

JZL184 Chemical Structure

CAS NO. 1101854-58-3

JZL184是一种有效的选择性单酰基甘油脂肪酶（MAGL）抑制剂。体内阻断内源性大麻素2-花生四烯酸甘油酯（2-AG）的水解（IC50 = 8 nM）。

库存：现货

规格	价格	数量
10 mg	￥ 280.00
25 mg	￥ 560.00
50 mg	￥ 910.00
100 mg	￥ 1,400.00
10mM * 1mL in DMSO	￥ 427.00

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生物活性

JZL184是一种有效的选择性单酰基甘油脂肪酶（MAGL）抑制剂。体内阻断内源性大麻素2-花生四烯酸甘油酯（2-AG）的水解（IC50 = 8 nM）。

溶解度 *

In vitro (25°C)	DMSO	86 mg/mL (165.22 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	5%DMSO+40%PEG300+5%Tween80+ddH2O	2.3 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	19.21 mL	96.06 mL	192.13 mL
0.5 mM	3.84 mL	19.21 mL	38.43 mL
1 mM	1.92 mL	9.61 mL	19.21 mL
5 mM	0.38 mL	1.92 mL	3.84 mL

*The above data is based on the productmolecular weight 520.49. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A12747
作用机制	Inhibitor (抑制剂)
M. Wt	520.49
Formula	C27H24N2O9
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	1101854-58-3
Synonyms	JZL-184, JZL 184
SMILES	C1CN(CCC1C(C2=CC3=C(C=C2)OCO3)(C4=CC5=C(C=C4)OCO5)O)C(=O)OC6=CC=C(C=C6)[N+](=O)[O-]