产品详情

生物活性

K03861是II型CDK2抑制剂，其CDK2（WT），CDK2（C118L），CDK2（A144C）和CDK2（C118L/A144C）的Kd分别为50 nM，18.6 nM，15.4 nM和9.7 nM。

靶点信息

CDK2(C118L/A144C)	CDK2(A144C)	CDK2(C118L)	CDK2(WT)
9.7 nM(Kd)	15.4 nM(Kd)	18.6 nM(Kd)	50 nM(Kd)

溶解度 *

In vitro	DMSO	97 mg/mL (193.42 mM)
	Water	Insoluble
	Ethanol	15 mg/mL (29.91 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	19.94 mL	99.7 mL	199.4 mL
0.5 mM	3.99 mL	19.94 mL	39.88 mL
1 mM	1.99 mL	9.97 mL	19.94 mL
5 mM	0.4 mL	1.99 mL	3.99 mL

*The above data is based on the productmolecular weight 501.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A15889
作用机制	Inhibitor (抑制剂)
M. Wt	501.5
Formula	C24H26F3N7O2
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	853299-07-7
Synonyms	K 03861, K-03861
SMILES	CN1CCN(CC2=C(C(F)(F)F)C=C(/N=C(O)/NC3=CC=C(OC(C=CN4)=NC4=N)C=C3)C=C2)CC1