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KC7F2是HIF-1α蛋白翻译的抑制剂，但不是转录的抑制剂，可抑制蛋白质合成的两个关键调节子，即真核翻译起始因子4E结合蛋白1（4EBP1）和p70 S6激酶（S6K）的磷酸化。
靶点信息
| HIF-1α | ||||
| 20 μM |
| In vitro | DMSO | 94 mg/mL (164.8 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 17.53 mL | 87.66 mL | 175.32 mL |
| 0.5 mM | 3.51 mL | 17.53 mL | 35.06 mL |
| 1 mM | 1.75 mL | 8.77 mL | 17.53 mL |
| 5 mM | 0.35 mL | 1.75 mL | 3.51 mL |
*The above data is based on the productmolecular weight 570.38. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A15359 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 570.38 |
| Formula | C16H16Cl4N2O4S4 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 927822-86-4 |
| SMILES | C1=CC(=C(C=C1Cl)S(=O)(=O)NCCSSCCNS(=O)(=O)C2=C(C=CC(=C2)Cl)Cl)Cl |
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