Selinexor (KPT-330)

Name: Selinexor (KPT-330)
SKU: A12582

目录号: A12582

CRM1 抑制剂

Product Citations (1)

Selinexor (KPT-330) Chemical Structure

CAS NO. 1393477-72-9

CRM1（XPO1）介导的核输出的KPT-330抑制剂在T细胞急性淋巴细胞白血病和急性骨髓性白血病的临床前模型中具有选择性的抗白血病活性。

库存：现货

规格	价格	数量
5 mg	￥ 420.00
10 mg	￥ 700.00
25 mg	￥ 1,400.00
50 mg	￥ 2,450.00
10mM * 1mL in DMSO	￥ 784.00

或

添加到收藏

产品仅用于科学研究，不针对患者销售，望谅解.

产品详情

生物活性

CRM1（XPO1）介导的核输出的KPT-330抑制剂在T细胞急性淋巴细胞白血病和急性骨髓性白血病的临床前模型中具有选择性的抗白血病活性。

靶点信息

CRM1 (Cell-free assay)

溶解度 *

In vitro (25°C)	DMSO	78 mg/mL (175.94 mM)
	Water	Insoluble
	Ethanol	36 mg/mL (81.21 mM)
In vivo	2% DMSO+40%PEG 300+5% Tween80 +ddH2O	3 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	22.56 mL	112.79 mL	225.58 mL
0.5 mM	4.51 mL	22.56 mL	45.12 mL
1 mM	2.26 mL	11.28 mL	22.56 mL
5 mM	0.45 mL	2.26 mL	4.51 mL

*The above data is based on the productmolecular weight 443.31. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A12582
作用机制	Inhibitor (抑制剂)
M. Wt	443.31
Formula	C17H11F6N7O
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	1393477-72-9
Synonyms	KPT330, KPT 330
SMILES	C1=CN=C(C=N1)NNC(=O)/C=C\N2C=NC(=N2)C3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F