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Laropiprant (MK0524)与烟酸合用可降低血液胆固醇。是一种有效的，选择性的 DP receptor 拮抗剂，Ki 值为 0.57 nM，对 TP 受体的 Ki 值为 2.95 nM。
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 22.94 mL | 114.71 mL | 229.41 mL |
| 0.5 mM | 4.59 mL | 22.94 mL | 45.88 mL |
| 1 mM | 2.29 mL | 11.47 mL | 22.94 mL |
| 5 mM | 0.46 mL | 2.29 mL | 4.59 mL |
*The above data is based on the productmolecular weight 435.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A11483 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 435.9 |
| Formula | C21H19ClFNO4S |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 571170-77-9 |
| Synonyms | Cardaptive, MK 0524, MK-0524 |
| SMILES | CS(=O)(=O)C1=C2C(=CC(=C1)F)C3=C(N2CC4=CC=C(C=C4)Cl)[C@H](CC3)CC(=O)O |
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