产品详情

生物活性

LB42708是一种有效的，口服活性和选择性的非肽法呢基转移酶抑制剂（FTase抑制剂）。

靶点信息

FTase (H-ras)	FTase (N-ras)	FTase (K-Ras)
0.8 nM	1.2 nM	2.0 nM

溶解度 *

In vitro	DMSO	95 mg/mL (171.03 mM)
	Water	Insoluble
	Ethanol	Warmed: 82 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	18 mL	90.02 mL	180.03 mL
0.5 mM	3.6 mL	18 mL	36.01 mL
1 mM	1.8 mL	9 mL	18 mL
5 mM	0.36 mL	1.8 mL	3.6 mL

*The above data is based on the productmolecular weight 555.46. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A14020
作用机制	Inhibitor (抑制剂)
M. Wt	555.46
Formula	C30H27BrN4O2
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	226929-39-1
Synonyms	LB-42708, LB 42708
SMILES	C1COCCN1C(=O)C2=CN(C=C2C3=CC=CC4=CC=CC=C43)CC5=CN=CN5CC6=CC=C(C=C6)Br