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LBH589 (Panobinostat)

LBH589 (Panobinostat)

Name: LBH589 (Panobinostat)
SKU: A10518

目录号: A10518

HDAC 抑制剂

Product Citations (5)

LBH589 (Panobinostat) Chemical Structure

CAS NO. 404950-80-7

LBH589是异羟肟酸，用作非选择性HDAC抑制剂，HDAC1的IC5o为0.23 nM。

库存：现货

规格	价格	数量
10 mg	￥ 350.00
50 mg	￥ 770.00
100 mg	￥ 1,050.00
200 mg	￥ 1,442.00
10mM * 1mL in DMSO	￥ 420.00

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生物活性

LBH589是异羟肟酸，用作非选择性HDAC抑制剂，HDAC1的IC5o为0.23 nM。

靶点信息

HDAC (MOLT-4 cells)	HDAC (Reh cells)
5 nM	20 nM

溶解度 *

In vitro (25°C)	DMSO	60 mg/mL (171.7 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	2% DMSO+48% PEG 300+2% Tween 80+ddH2O	4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	28.62 mL	143.1 mL	286.2 mL
0.5 mM	5.72 mL	28.62 mL	57.24 mL
1 mM	2.86 mL	14.31 mL	28.62 mL
5 mM	0.57 mL	2.86 mL	5.72 mL

*The above data is based on the productmolecular weight 349.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A10518
作用机制	Inhibitor (抑制剂)
M. Wt	349.4
Formula	C21H23N3O2
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	404950-80-7
Synonyms	NVP-LBH589, LBH-589
SMILES	CC1=C(C2=CC=CC=C2N1)CCNCC3=CC=C(C=C3)/C=C/C(=O)NO