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LDN193189 HCl是ldn193189的盐酸盐。LDN193189是一种高效的小分子BMP抑制剂，可抑制BMP I型受体ALK2（IC50：5 nM），ALK3（IC50：30 nM）和ALK6（TGFβ1/ BMP信号转导）以及随后的SMAD磷酸化。
靶点信息
| ALK2 (C2C12 cells) | ALK3 (C2C12 cells) | |||
| 5 nM | 30 nM |
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 22.58 mL | 112.88 mL | 225.76 mL |
| 0.5 mM | 4.52 mL | 22.58 mL | 45.15 mL |
| 1 mM | 2.26 mL | 11.29 mL | 22.58 mL |
| 5 mM | 0.45 mL | 2.26 mL | 4.52 mL |
*The above data is based on the productmolecular weight 442.94. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A11478 |
|---|---|
| M. Wt | 442.94 |
| Formula | C25H22N6.HCl |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1062368-62-0 |
| Synonyms | LDN 193189 |
| SMILES | C1CN(CCN1)C2=CC=C(C=C2)C3=CN4C(=C(C=N4)C5=CC=NC6=CC=CC=C56)N=C3.Cl.Cl.Cl.Cl |
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