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LDN193189

目录号: A11205

ALK 抑制剂

LDN193189

LDN193189 Chemical Structure

CAS NO. 1062368-24-4

LDN193189是一种高效的小分子BMP抑制剂，可抑制BMP I型受体ALK2（IC50=5 nM），ALK3（IC50=30 nM）和ALK6（TGFβ1/BMP信号转导）以及随后的SMAD磷酸化。

库存： 现货

规格 价格 数量
2 mg
￥ 280.00
5 mg
￥ 490.00
25 mg
￥ 980.00
50 mg
￥ 1,680.00
或
Warning 产品仅用于科学研究，不针对患者销售，望谅解.
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生物活性

LDN193189是一种高效的小分子BMP抑制剂，可抑制BMP I型受体ALK2（IC50=5 nM），ALK3（IC50=30 nM）和ALK6（TGFβ1/BMP信号转导）以及随后的SMAD磷酸化。
靶点信息
ALK2 (C2C12 cells) ALK3 (C2C12 cells)
5 nM30 nM

溶解度 *

In vitro DMSO Insoluble
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 24.6 mL 123.01 mL 246.01 mL
0.5 mM 4.92 mL 24.6 mL 49.2 mL
1 mM 2.46 mL 12.3 mL 24.6 mL
5 mM 0.49 mL 2.46 mL 4.92 mL

*The above data is based on the productmolecular weight 406.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号 A11205
作用机制 Inhibitor (抑制剂)
M. Wt 406.48
Formula C25H22N6
Purity >99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No. 1062368-24-4
Synonyms LDN-193189
SMILES C1CN(CCN1)C2=CC=C(C=C2)C3=CN4C(=C(C=N4)C5=CC=NC6=CC=CC=C56)N=C3

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