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Lerociclib dihydrochloride (G1T38 dihydrochloride) is a potent and selective inhibitor of CDK4/CDK6, with IC50s of 1 nM and 2 nM for CDK4/CyclinD1 and CDK6/CyclinD3, respectively.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 18.26 mL | 91.32 mL | 182.64 mL |
| 0.5 mM | 3.65 mL | 18.26 mL | 36.53 mL |
| 1 mM | 1.83 mL | 9.13 mL | 18.26 mL |
| 5 mM | 0.37 mL | 1.83 mL | 3.65 mL |
*The above data is based on the productmolecular weight 547.52. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A21577 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 547.52 |
| Formula | C26H36Cl2N8O |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 2097938-59-3 |
| Synonyms | G1T38 dihydrochloride, G1T 38, G1T-38 |
| SMILES | O=C1NCC2(N3C1=CC4=CN=C(NC5=NC=C(N6CCN(C(C)C)CC6)C=C5)N=C43)CCCCC2.[H]Cl.[H]Cl |
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