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Letaxaban (TAK-442)是一种有效的，选择性的，口服活性的Xa抑制剂，是一种四氢嘧啶-2（1H）-衍生物。TAK-442在贫血小板的人[半最大抑制浓度（IC（50））：53 nM，TAK-442]和大鼠（IC（50）：32 nM，TAK-442）血浆中抑制内源性FXa活性。
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 20.83 mL | 104.17 mL | 208.34 mL |
| 0.5 mM | 4.17 mL | 20.83 mL | 41.67 mL |
| 1 mM | 2.08 mL | 10.42 mL | 20.83 mL |
| 5 mM | 0.42 mL | 2.08 mL | 4.17 mL |
*The above data is based on the productmolecular weight 479.98. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A12871 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 479.98 |
| Formula | C22H26ClN3O5S |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 870262-90-1 |
| Synonyms | TAK 442; TAK442 |
| SMILES | C1CNC(=O)N(C1)C2CCN(CC2)C(=O)[C@@H](CS(=O)(=O)C3=CC4=C(C=C3)C=C(C=C4)Cl)O |
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