LXR

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LXR-623

Catalog No. A21366
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LXRα and full LXRβ agonist

LXR-623 is a brain-penetrant partial LXRα and full LXRβ agonist, with IC50s of 24 nM and 179 nM, respectively. 了解更多

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RGX-104 free Acid

Catalog No. A21513
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LXR agonist

RGX-104 free Acid is an orally bioavailable and potent liver-X nuclear hormone receptor (LXR) agonist that modulates innate immunity via transcriptional activation of the ApoE gene. 了解更多

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AZ876

Catalog No. A21026
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LXR agonist

AZ876 is a novel high-affinity LXR agonist. 了解更多

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GW3965 HCl

Catalog No. A11204
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LXR-like receptors 激动剂

GW3965 HCl是一种选择性的口服活性肝X受体（LXR）完全激动剂。了解更多

Product Citations (3)

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- Mohácsik P, .et al. A Transgenic Mouse Model for Detection of Tissue-Specific Thyroid Hormone Action, Endocrinology, 2018, Feb 1;159(2):1159-1171 PMID: 29253128
- Pencheva N, .et al. Broad-spectrum therapeutic suppression of metastatic melanoma through nuclear hormone receptor activation., Cell., 2014, 156(5):986-1001 PMID: 24581497
- Bin Dong, .et al. High-fructose diet downregulates long-chain acyl-CoA synthetase 3 expression in liver of hamsters via impairing LXR/RXR signaling pathway, J Lipid Res., 2013, May; 54(5): 1241-1254. PMID: 23427282
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T0901317

Catalog No. A12652
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LXR/FXR 激动剂

T0901317是有效的，高亲和力的肝X受体（LXR）激动剂（EC50~50 nM，LXR-β和LXR-β的Kd值分别为7和22 nM）。了解更多

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- Tian Yongsong, .et al. Tritium hydrogen-isotope exchange with electron-poor tertiary benzenesulfonamide moiety; application in late-stage labeling of T0901317, J Labelled Comp Radiopharm, 2022, Feb;65(2):36-44 PMID: 34957593
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GW3965

Catalog No. A15100
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Liver X Receptor 激动剂

GW3965是hLXRα和hLXRβ的有效选择性LXR激动剂，EC50分别为190和30 nM。了解更多

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- B Dong ,etc. High-fructose diet downregulates long-chain acyl-CoA synthetase 3 expression in liver of hamsters via impairing LXR/RXR signaling pathway. Journal of lipid research, 2013, 54(5), 1241-1254.
- N Pencheva ,etc. Broad-spectrum therapeutic suppression of metastatic melanoma through nuclear hormone receptor activation. Cell, 2014, 156(5), 986-1001.
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Sobetirome

Catalog No. A15241
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TRβ 激动剂

Sobetirome是一种甲状腺激素受体β（TRβ）特异性激动剂，Sobetirome设计用于选择性结合TRβ-1，EC50为0.16 μM。了解更多

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SR9243

Catalog No. A15535
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LXR 激动剂

SR9243是有效的选择性LXR反向激动剂。SR9243通过抑制脂质产生和Warburg效应杀死癌细胞。它在多种类型的癌症中诱导细胞死亡，并且不会引起副作用，而这些副作用已使先前针对这些过程的尝试脱轨。了解更多

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SR9238

Catalog No. A15763
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LXR Inverse 激动剂

SR9238是有效的选择性LXR反向激动剂（LXRβ和LXRα的IC50值分别为43和214 nM）。了解更多

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