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LY2857785是一种有效的选择性CDK9抑制剂。显着降低RNA聚合酶II CTD的磷酸化并显着降低MCL1蛋白水平，从而导致多种白血病和实体瘤细胞系发生凋亡。
| In vitro | DMSO | 22 mg/mL (49.04 mM) | |
| Water | Insoluble | ||
| Ethanol | 40 mg/mL (89.16 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 22.29 mL | 111.46 mL | 222.92 mL |
| 0.5 mM | 4.46 mL | 22.29 mL | 44.58 mL |
| 1 mM | 2.23 mL | 11.15 mL | 22.29 mL |
| 5 mM | 0.45 mL | 2.23 mL | 4.46 mL |
*The above data is based on the productmolecular weight 448.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A15823 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 448.6 |
| Formula | C26H36N6O |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1619903-54-6 |
| Synonyms | LY-2857785, LY 2857785 |
| SMILES | CC(C)C1=C2C=C(C=CC2=NN1C)C3=NC(=NC=C3)NC4CCC(CC4)NC5CCOCC5 |
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