Metabotropic glutamate receptors (mGluR)

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  1. LY2794193

    Catalog No. A19131
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    mGlu3 receptor agonist
    LY2794193 is a highly potent and selective mGlu3 receptor agonist (hmGlu3 Ki=0.927 nM??EC50=0.47 nM; hmGlu2 Ki=412 nM??EC50=47.5 nM). 了解更多
  2. LY2812223

    Catalog No. A21100
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    mGlu2 receptor agonist
    LY2812223 is a highly potent, functionally selective mGlu2 receptor agonist with mGlu2 binding affinity for mGlu2 and mGlu3 (Ki=144 nM and 156 nM, respectively). 了解更多
  3. O-Phospho-L-serine

    Catalog No. A21159
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    group III mGluR receptors agonist
    O-Phospho-L-serine is the immediate precursor to L-serine in the serine synthesis pathway, and an agonist at the group III mGluR receptors (mGluR4, mGluR6, mGluR7, and mGluR8); O-Phospho-L-serine also acts as a weak antagonist for mGluR1 and a potent antagonist for mGluR2. 了解更多
  4. L-APB

    Catalog No. A21872
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    mGluRs M3 agonist
    L-APB is a potent and specific agonist for the group III mGluRs, with EC50s of 0.13, 0.29, 1.0, 249 μM for mGlu4, mGlu8, mGlu6 and mGlu7 receptors, respectively. 了解更多
  5. (1R,2S)-VU0155041

    Catalog No. A21933
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    partial mGluR4 agonist
    (1R,2S)-VU0155041, Cis regioisomer of VU0155041, is a partial mGluR4 agonist with an EC50 of 2.35 μM. 了解更多
  6. CHPG sodium salt

    Catalog No. A21968
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    mGluR5 agonist
    CHPG sodium salt is a selective mGluR5 agonist, and attenuates SO2-induced oxidative stress and inflammation through TSG-6/NF-κB pathway in BV2 microglial cells. 了解更多
  7. Eglumegad

    Catalog No. A21005
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    group II (mGlu2/3) receptor agonist
    Eglumegad (LY354740) is a highly potent and selective group II (mGlu2/3) receptor agonist with IC50s of 5 and 24 nM on transfected human mGlu2 and mGlu3 receptors, respectively. 了解更多
  8. VU6005649

    Catalog No. A17023
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    CNS penetrant mGlu7/8 receptor 激动剂
    VU6005649是一种CNS渗透性mGlu7/8受体激动剂,对mGlu7受体和mGlu8受体的EC50分别为0.65 μM和2.6 μM。 了解更多
  9. LY2979165

    Catalog No. A11487
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    mGlu2 激动剂
    LY2979165是mglu2激动剂。 了解更多
  10. LY2140023 (LY404039)

    Catalog No. A10544
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    mGluR 激动剂
    LY-404039是一种用于科学研究的药物,用作代谢型谷氨酸受体II亚型mGluR2和mGluR3的选择性激动剂。它在动物研究中具有抗焦虑和抗精神病作用,但不会引起镇静作用。早期的人体试验使用LY-404,039前药形式LY-214,0023,也取得了令人鼓舞的结果。 了解更多
  11. LY 379268

    Catalog No. A13123
    mGlu2 receptor 激动剂
    LY 379268是高选择性的II类mGlu受体激动剂(对于hmGlu2和hmGlu3而言,EC50值分别为2.69和4.48 nM),其选择性是I类和III类受体的80倍以上。 了解更多
  12. Ibotenic Acid

    Catalog No. A14006
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    NMDA& mGlu receptor 激动剂
    Ibotenic Acid是最初从鹅膏菌属物种中分离出来的一种神经兴奋性氨基酸,它起着NMDA和代谢型谷氨酸受体激动剂的作用。 了解更多
  13. Kainic acid monohydrate

    Catalog No. A13485
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    Kainate receptor 激动剂
    Kainic acid monohydrate是海藻酸酯类离子型谷氨酸受体激动剂。可在体内诱发癫痫发作和神经退行性变,也已用于在啮齿动物中诱发实验性癫痫和检查兴奋性诱发的神经元凋亡机制。 了解更多
  14. (S)-3,5-DHPG

    Catalog No. A16108
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    mGluR 激动剂
    (S)-3,5-DHPG是I类代谢型谷氨酸受体(mGluRs)的激动剂,与mGluR1a和mGluR5a(分别为Ki = 0.9和3.9 uM)结合,但不与离子型谷氨酸受体结合。 了解更多

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