Metabotropic glutamate receptors (mGluR)
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mGlu5 modulator
VU0652835 is a metabotropic glutamate receptor subtype 5 (mGlu5) negative allosteric modulator with an IC50 of 81 nM.
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mGlu4 receptors modulator
VU 0364770是mGlu4受体的正变构调节剂,在表达mGlu4的HEK 293细胞中EC50值为290 nM。
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mGluR5 Modulator
VU0364289是新型N-芳基哌嗪mGlu5阳性变构调节剂。
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mGluR-2 modulator
JNJ-42153605是亲代谢型谷氨酸2受体的正变构调节剂。
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mGluR5 modulator
ADX-47273是一种有效的,特异性的mGlu5正变构调节剂(PAM)EC50为0.17 μM,对其他亚型没有作用活性。
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mGluR2 modulator
BINA是mGlu2的选择性正构构调节剂(在表达人mGlu2的CHO细胞中EC50 = 33.2 nM)。
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GluR modulator
VU 0364439是mGlu4受体的正变构调节剂(PAM)(对于人mGlu4,体外EC50 = 19.8 nM)。
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mGlu4 receptors modulator
VU 0361737是mGluR-4的选择性正变构调节剂(人和大鼠受体的EC50值分别为240和110 nM)。
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mGlu5 negative allosteric modulator
Basimglurant (RG7090) is a potent, selective and orally available mGlu5 negative allosteric modulator with a Kd of 1.1 nM.
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mGluR5 positive allosteric modulator
(R)-ADX-47273 is a potent mGluR5 positive allosteric modulator, with an EC50 of 168 nM for potentiation .
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mGlu4 receptor modulator
TCN238 is a positive allosteric mGlu4 receptor modulator with an EC50 of 1 μM.
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mGlu4 receptor modulator
Lu AF21934 is a selective and brain-penetrant mGlu4 receptor positive allosteric modulator with an IC50 of 500 nM for human mGlu4.
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mGluR5 positive allosteric modulator
BMT-145027 is an mGluR5 positive allosteric modulator without inherent agonist activity, exhibits an EC50 of 47 nM.
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mGlu2 receptor modulator
CBiPES HCl是mGluR-2的选择性正变构调节剂,IC50值为98.2 nM。
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mGluR1 modulator
CPPHA是mGluR5受体的选择性正变构调节剂。
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