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MI-1061 is a potent, orally bioavailable, and chemically stable MDM2 (MDM2-p53 interaction) inhibitor (IC50=4.4 nM; Ki=0.16 nM). MI-1061 potently activates p53, induces apoptosis, and has anti-tumor activity.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 17.17 mL | 85.84 mL | 171.69 mL |
| 0.5 mM | 3.43 mL | 17.17 mL | 34.34 mL |
| 1 mM | 1.72 mL | 8.58 mL | 17.17 mL |
| 5 mM | 0.34 mL | 1.72 mL | 3.43 mL |
*The above data is based on the productmolecular weight 582.45. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A18450 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 582.45 |
| Formula | C30H26Cl2FN3O4 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1410737-34-6 |
| Synonyms | MI1061, MI 1061 |
| SMILES | O=C(O)C1=CC=C(NC([C@H](N2)[C@H](C3=CC=CC(Cl)=C3F)[C@]4(C(NC5=C4C=CC(Cl)=C5)=O)C62CCCCC6)=O)C=C1 |
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