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CCR

23 个项目

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  1. ZK-756326 dihydrochloride
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    ZK-756326 dihydrochloride

    Catalog No. A16363
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    CCR8 激动剂
    ZK-756326是有效的，选择性的非肽CCR8趋化因子受体激动剂。ZK 756326抑制了CCR8配体I-309（CCL1）的结合，IC（50）值为1.8μM。 了解更多
  2. NSC5844
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    NSC5844

    Catalog No. A15924
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    CCR1 激动剂
    NSC5844是具有C-C趋化因子受体1型（CCR1）激动特性的双喹啉化合物。 了解更多
  3. Vicriviroc maleate
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    Vicriviroc maleate

    Catalog No. A15276
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    CCR5 拮抗剂
    Vicriviroc maleate是一种CCR5拮抗剂，在临床开发中用于治疗HIV-1的IC50为0.91 nM。 了解更多
  4. RS 504393
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    RS 504393

    Catalog No. A15227
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    CCR2 拮抗剂
    RS 504393是一种选择性CCR2趋化因子受体拮抗剂（IC50值分别为98 nM和> 100 uM，分别抑制人重组CCR2b和CCR1受体）。 了解更多
  5. MK-0812
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    MK-0812

    Catalog No. A11127
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    CCR2 拮抗剂
    MK-0812是一种有效的选择性CCR2拮抗剂，对人单核细胞上CCR2的亲和力低，而在趋化性测定中的亲和力却低。它在临床前物种中具有良好的PK分布，并在动物模型中证明了功效。 了解更多
  6. INCB 3284 dimesylate
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    INCB 3284 dimesylate

    Catalog No. A11104
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    HCCR2 拮抗剂
    INCB 3284 dimesylate是一种有效的选择性hCCR2拮抗剂，对单核细胞趋化因子分子与hCCR2的结合和趋化活性表现出强烈的拮抗作用。 了解更多
  7. INCB8761 (PF-4136309)
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    INCB8761 (PF-4136309)

    Catalog No. A11136
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    CCR2 拮抗剂
    INCB8761 (PF-4136309)是一种有效的，选择性的，口服可生物利用的CCR2拮抗剂。 了解更多
  8. Vicriviroc Malate
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    Vicriviroc Malate

    Catalog No. A10971
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    CCR5 拮抗剂
    Vicriviroc Malate是CCR5拮抗剂，也是HIV-1进入靶细胞的有效抑制剂，对HIV分离株的平均IC50 = 0.46 nM，IC50 = 1?10 nM（n = 52）。 了解更多
  9. Maraviroc (UK-427857)
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    Maraviroc (UK-427857)

    Catalog No. A10556
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    CCR 拮抗剂
    Maraviroc (UK-427857)是CCR5受体拮抗剂类别的抗逆转录病毒药物，用于治疗HIV感染。 了解更多
  10. CCR4 antagonist 2
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    CCR4 antagonist 2

    Catalog No. A18471
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    CCR4 拮抗剂
    CCR4 antagonist 2 (Compound 31) is a novel potent, orally bioavailable small molecule antagonists of CC chemokine receptor 4 (CCR4) that inhibits Treg trafficking into the Tumor Microenvironment without suppressing the number of Treg in healthy tissues. 了解更多
  11. ML604086
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    ML604086

    Catalog No. A18969
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    CCR8 抑制剂
    ML604086 is a selective CCR8 inhibitor, inhibiting CCL1 binding to CCR8 on circulating T-cells. ML604086 inhibits CCL1 mediated chemotaxis and increases in intracellular Ca2+ concentrations. 了解更多
  12. AZ084
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    AZ084

    Catalog No. A19143
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    CCR8 拮抗剂
    AZ084 is a potent, selective, allosteric and oral active CCR8 antagonist, with a Ki of 0.9 nM. Has potential to treat asthma. 了解更多
  13. GW 766994
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    GW 766994

    Catalog No. A20039
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    CCR3 拮抗剂
    GW 766994 is a specific and oral chemokine receptor-3 (CCR3) antagonist, which has entered clinical trial for asthma and eosinophilic bronchitis. 了解更多
  14. INCB3344
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    INCB3344

    Catalog No. A11465
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    CCR2 拮抗剂
    INCB3344 is a potent, selective and orally bioavailable CCR2 antagonist with IC50 values of 5.1 nM (hCCR2) and 9.5 nM (mCCR2) in binding antagonism and 3.8 nM (hCCR2) and 7.8 nM (mCCR2) in antagonism of chemotaxis activity. 了解更多
  15. LMD-009
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    LMD-009

    Catalog No. A18643
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    CCR8 激动剂
    LMD-009 is a selective CCR8 nonpeptide agonist. LMD-009 mediates chemotaxis, inositol phosphate accumulation, and calcium release in high potencies with EC50s from 11 to 87 nM. 了解更多
  16. PF-04634817
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    PF-04634817

    Catalog No. A18659
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    CCR2 /CCR5 dual 拮抗剂
    PF-04634817 is an orally administered CCR2 and CCR5 chemokine receptor antagonist, for the treatment of diabetic nephropathies and diabetic macular oedema. 了解更多
  17. BI-639667
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    BI-639667

    Catalog No. A18747
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    Human CCR1 拮抗剂
    BI-639667 is a potent and selective antagonist of human CCR1. 了解更多
  18. Cenicriviroc Mesylate
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    Cenicriviroc Mesylate

    Catalog No. A17028
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    CCR2/5 receptors 抑制剂
    Cenicriviroc(TAK-652,TBR-652)是CCR2和CCR5受体的抑制剂，可使其充当防止病毒进入人细胞的进入抑制剂 了解更多
  19. BMS-813160
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    BMS-813160

    Catalog No. A17040
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    CCR2/CCR5 拮抗剂
    BMS-813160是一种有效的选择性CCR2/CCR5拮抗剂，具有潜在的免疫调节和抗肿瘤活性。 了解更多
  20. Aplaviroc
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    Aplaviroc

    Catalog No. A13471
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    CCR5 entry 抑制剂
    Aplaviroc是一种CCR5进入抑制剂，用于治疗HIV感染。 了解更多
  21. Cenicriviroc
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    Cenicriviroc

    Catalog No. A13643
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    CCR2/CCR5 抑制剂
    Cenicriviroc是用于治疗HIV感染的实验性候选药物.Cenicriviroc是CCR2和CCR5受体的抑制剂，可使其充当阻止病毒进入人体细胞的进入抑制剂。 了解更多
  22. TAK-779
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    TAK-779

    Catalog No. A13846
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    CCR5 拮抗剂
    TAK-779是一种新颖，有效和选择性的CCR5小分子拮抗剂，在结合试验中IC50值为1.4nM。 了解更多
  23. BX471
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    BX471

    Catalog No. A14409
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    CCR1 拮抗剂
    BX471是一种有效的选择性非肽CCR1拮抗剂（对于人CCR1，Ki = 1 nM），对CCR1的选择性是CCR2，CCR5和CXCR4的250倍。 了解更多

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