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CCR

CCR

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Vicriviroc maleate

Catalog No. A15276
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CCR5 拮抗剂

Vicriviroc maleate是一种CCR5拮抗剂，在临床开发中用于治疗HIV-1的IC50为0.91 nM。了解更多

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RS 504393

Catalog No. A15227
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CCR2 拮抗剂

RS 504393是一种选择性CCR2趋化因子受体拮抗剂（IC50值分别为98 nM和> 100 uM，分别抑制人重组CCR2b和CCR1受体）。了解更多

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MK-0812

Catalog No. A11127
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CCR2 拮抗剂

MK-0812是一种有效的选择性CCR2拮抗剂，对人单核细胞上CCR2的亲和力低，而在趋化性测定中的亲和力却低。它在临床前物种中具有良好的PK分布，并在动物模型中证明了功效。了解更多

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- Murakami K, .et al. CC chemokine ligand 2 and CXC chemokine ligand 8 as neutrophil chemoattractant factors in canine idiopathic polyarthritis, Vet Immunol Immunopathol, 2016, Dec;182:52-58 PMID: 27863550
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INCB 3284 dimesylate

Catalog No. A11104
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HCCR2 拮抗剂

INCB 3284 dimesylate是一种有效的选择性hCCR2拮抗剂，对单核细胞趋化因子分子与hCCR2的结合和趋化活性表现出强烈的拮抗作用。了解更多

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INCB8761 (PF-4136309)

Catalog No. A11136
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CCR2 拮抗剂

INCB8761 (PF-4136309)是一种有效的，选择性的，口服可生物利用的CCR2拮抗剂。了解更多

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Vicriviroc Malate

Catalog No. A10971
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CCR5 拮抗剂

Vicriviroc Malate是CCR5拮抗剂，也是HIV-1进入靶细胞的有效抑制剂，对HIV分离株的平均IC50 = 0.46 nM，IC50 = 1?10 nM（n = 52）。了解更多

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- Tomohiro Nabekura, .et al. Effects of Antiviral Drugs on Organic Anion Transport in Human Placental BeWo Cells, Antimicrob Agents Chemother, 2015, Dec; 59(12): 7666-7670 PMID: 26416870
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Maraviroc (UK-427857)

Catalog No. A10556
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CCR 拮抗剂

Maraviroc (UK-427857)是CCR5受体拮抗剂类别的抗逆转录病毒药物，用于治疗HIV感染。了解更多

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- Roman V Uzhachenko, .et al. Metabolic modulation by CDK4/6 inhibitor promotes chemokine-mediated recruitment of T cells into mammary tumors, Cell Rep, 2021, Apr 6;35(1):108944 PMID: 33826903
- Karampoor S, .et al. Maraviroc attenuates the pathogenesis of experimental autoimmune encephalitis, Int Immunopharmacol, 2020, Mar;80:106138 PMID: 32007705
- Taisuke Ito, .et al. CCR5 is a novel target for the treatment of experimental alopecia areata, JCIA, 2020, 22 January
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CCR4 antagonist 2

Catalog No. A18471
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CCR4 拮抗剂

CCR4 antagonist 2 (Compound 31) is a novel potent, orally bioavailable small molecule antagonists of CC chemokine receptor 4 (CCR4) that inhibits Treg trafficking into the Tumor Microenvironment without suppressing the number of Treg in healthy tissues. 了解更多

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AZ084

Catalog No. A19143
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CCR8 拮抗剂

AZ084 is a potent, selective, allosteric and oral active CCR8 antagonist, with a Ki of 0.9 nM. Has potential to treat asthma. 了解更多

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GW 766994

Catalog No. A20039
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CCR3 拮抗剂

GW 766994 is a specific and oral chemokine receptor-3 (CCR3) antagonist, which has entered clinical trial for asthma and eosinophilic bronchitis. 了解更多

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INCB3344

Catalog No. A11465
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CCR2 拮抗剂

INCB3344 is a potent, selective and orally bioavailable CCR2 antagonist with IC50 values of 5.1 nM (hCCR2) and 9.5 nM (mCCR2) in binding antagonism and 3.8 nM (hCCR2) and 7.8 nM (mCCR2) in antagonism of chemotaxis activity. 了解更多

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PF-04634817

Catalog No. A18659
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CCR2 /CCR5 dual 拮抗剂

PF-04634817 is an orally administered CCR2 and CCR5 chemokine receptor antagonist, for the treatment of diabetic nephropathies and diabetic macular oedema. 了解更多

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BI-639667

Catalog No. A18747
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Human CCR1 拮抗剂

BI-639667 is a potent and selective antagonist of human CCR1. 了解更多

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BMS-813160

Catalog No. A17040
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CCR2/CCR5 拮抗剂

BMS-813160是一种有效的选择性CCR2/CCR5拮抗剂，具有潜在的免疫调节和抗肿瘤活性。了解更多

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TAK-779

Catalog No. A13846
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CCR5 拮抗剂

TAK-779是一种新颖，有效和选择性的CCR5小分子拮抗剂，在结合试验中IC50值为1.4nM。了解更多

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BX471

Catalog No. A14409
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CCR1 拮抗剂

BX471是一种有效的选择性非肽CCR1拮抗剂（对于人CCR1，Ki = 1 nM），对CCR1的选择性是CCR2，CCR5和CXCR4的250倍。了解更多

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