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Microbiology /
HIV Protease

HIV Protease

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Ritonavir

Catalog No. A10799
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HIV Protease 抑制剂

Ritonavir是一种蛋白酶抑制剂，具有抗人类免疫缺陷病毒1型(hiv-1)的活性。蛋白酶抑制剂阻断hiv中被称为蛋白酶的部分，利托那韦抑制hiv病毒蛋白酶，这种蛋白酶防止gag-pol多蛋白的裂解，从而产生非感染性的未成熟病毒颗粒。了解更多

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Lopinavir (ABT-378)

Catalog No. A10537
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HIV Protease 抑制剂

Lopinavir (ABT-378)是HIV蛋白酶的抑制剂。了解更多

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Atazanavir sulfate (BMS-232632-05)

Catalog No. A10096
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HIV Protease 抑制剂

Atazanavir sulfate (BMS-232632-05)是蛋白酶抑制剂（PI）类的抗逆转录病毒药物。是一种高选择性的 HIV-1蛋白酶抑制剂。了解更多

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Atazanavir

Catalog No. A10097
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HIV Protease 抑制剂

Atazanavir是一种氮杂肽及HIV-蛋白酶抑制剂，常与其他抗HIV药物结合，用于治疗HIV感染以及获得性免疫缺乏综合征。了解更多

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Saquinavir

Catalog No. A11378
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HIV Protease 抑制剂

Saquinavir是蛋白酶抑制剂。蛋白酶是将蛋白质分子切割成更小片段的酶。Saquinavir抑制HIV-1和HIV-2蛋白酶。了解更多

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- Reiko Watanabe, .et al. Development of an In Silico Prediction Model for P-glycoprotein Efflux Potential in Brain Capillary Endothelial Cells toward the Prediction of Brain Penetration, J Med Chem, 2021, Mar 11;64(5):2725-2738 PMID: 33619967
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Darunavir Ethanolate (Prezista)

Catalog No. A11853
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HIV protease 抑制剂

Darunavir Ethanolate (Prezista)是一种HIV蛋白酶抑制剂。了解更多

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GSK2838232A

Catalog No. A13156
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HIV maturation 抑制剂

GSK2838232是一种新型的人类免疫病毒（HIV）成熟抑制剂，正在开发用于治疗慢性HIV感染。了解更多

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Fosamprenavir

Catalog No. A12583
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HIV protease 抑制剂

Fosamprenavir是amprenavir的前药，amprenavir是人类免疫缺陷病毒（HIV）蛋白酶的抑制剂。了解更多

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Darunavir

Catalog No. A20829
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HIV protease inhibitor

Darunavir is an HIV protease inhibitor 了解更多

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GSK2838232

Catalog No. A15965
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HIV maturation 抑制剂

GSK2838232是一种新型的人类免疫病毒（HIV）成熟抑制剂，正在开发用于治疗慢性HIV感染。了解更多

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(±)-BI-D

Catalog No. A16024
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Allosteric IN 抑制剂

(±)-BI-D 是有效的ALLINI（一种变构IN抑制剂），在LEDGF/p75结合位点结合整合酶。了解更多

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Nelfinavir

Catalog No. A11504
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HIV-1 protease 抑制剂

Nelfinavir是一种有效的口服生物可利用的人类免疫缺陷病毒HIV-1蛋白酶抑制剂(Ki=2 nM ),广泛用于与HIV逆转录酶抑制剂联合治疗HIV感染。了解更多

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- Reiko Watanabe, .et al. Development of an In Silico Prediction Model for P-glycoprotein Efflux Potential in Brain Capillary Endothelial Cells toward the Prediction of Brain Penetration, J Med Chem, 2021, Mar 11;64(5):2725-2738 PMID: 33619967
- Yang PM, .et al. p38α/S1P/SREBP2 activation by the SAM-competitive EZH2 inhibitor GSK343 limits its anticancer activity but creates a druggable vulnerability in hepatocellular carcinoma, Am J Cancer Res, 2019, Oct 1;9(10):2120-2139 PMID: 31720078
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Trovirdine

Catalog No. A13199
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HIV-1 RT 抑制剂

Trovirdine当使用杂聚合引物/模板（寡DNA/核糖体RNA）和dGTP作为底物时，trovirdine抑制HIV-1 RT的IC50为7 nM。了解更多

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Enfuvirtide Acetate(T-20)

Catalog No. A15825
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HIV fusion 抑制剂

Enfuvirtide Acetate (T-20)是一个36个氨基酸的肽段，对应于gp41（HIV-1包膜蛋白的跨膜亚基）区域。了解更多

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Tipranavir

Catalog No. A15262
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HIV protease 抑制剂

Tipranavir是一种非肽类HIV蛋白酶抑制剂（NPPI），可抑制HIV-1蛋白酶的酶促活性和二聚作用，对多种抗PI的HIV-1分离株具有有效的活性。了解更多

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Fosamprenavir Calcium Salt

Catalog No. A15089
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HIV protease 抑制剂

Fosamprenavir Calcium Salt 是抗逆转录病毒蛋白酶抑制剂amprenavir的磷酸酯前药，与母体分子相比具有更高的溶解度，并有可能减轻当前给药方案中的药丸负担；GW433908G是前药的钙盐。了解更多

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BMS-663068 Tris

Catalog No. A15026
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HIV-1 attachment 抑制剂

BMS-663068 tris是HIV-1附着抑制剂，可用于治疗HIV-1感染。了解更多

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BMS-663068 (Fostemsavir)

Catalog No. A15025
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HIV-1 attachment 抑制剂

BMS-663068 (Fostemsavir)是治疗HIV-1感染的HIV-1附着抑制剂。了解更多

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- Min Li, .et al. Clearance of HIV infection by selective elimination of host cells capable of producing HIV, Nat Commun, 2020, 11: 4051 PMID: 32792548
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Bevirimat

Catalog No. A14194
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HIV-1 maturation 抑制剂

Bevirimat (PA-457,MPC-4326,YK FH312) 是HIV-1病毒颗粒成熟抑制剂。了解更多

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- Mingzhang Wang, .et al. Quenching protein dynamics interferes with HIV capsid maturation, Nat Commun, 2017, 8: 1779 PMID: 29176596

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