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MK-8245 Trifluoroacetate是硬脂酰辅酶A去饱和酶（SCD）的肝靶向抑制剂，对人SCD1的IC50为1 nM，对大鼠SCD1和小鼠SCD1的IC50为3 nM，具有抗糖尿病和抗血脂异常的功效。
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 17.2 mL | 86.02 mL | 172.04 mL |
| 0.5 mM | 3.44 mL | 17.2 mL | 34.41 mL |
| 1 mM | 1.72 mL | 8.6 mL | 17.2 mL |
| 5 mM | 0.34 mL | 1.72 mL | 3.44 mL |
*The above data is based on the productmolecular weight 581.27. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A15170 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 581.27 |
| Formula | C19H17BrF4N6O6 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1415559-41-9 |
| Synonyms | MK 8245 Trifluoroacetate, MK8245 Trifluoroacetate |
| SMILES | C1CN(CCC1OC2=C(C=CC(=C2)F)Br)C3=NOC(=C3)C4=NN(N=N4)CC(=O)O.C(=O)(C(F)(F)F)O |
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