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MZP-54 is a selective degrader of BRD3/4 based on PROTAC technology, with a Kd of 4 nM for Brd4BD2.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 9.65 mL | 48.23 mL | 96.46 mL |
| 0.5 mM | 1.93 mL | 9.65 mL | 19.29 mL |
| 1 mM | 0.96 mL | 4.82 mL | 9.65 mL |
| 5 mM | 0.19 mL | 0.96 mL | 1.93 mL |
*The above data is based on the productmolecular weight 1036.67. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A19426 |
|---|---|
| 作用机制 | Degrader (降解剂) |
| M. Wt | 1036.67 |
| Formula | C55H66ClN7O9S |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 2010159-47-2 |
| Synonyms | MZP54, MZP 54 |
| SMILES | O=C(NCCOCCOCCOCC(N[C@@H](C(C)(C)C)C(N1C[C@H](O)C[C@H]1C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)=O)=O)C(C=C4)=CC=C4C5=CC6=C(C=C5)N(C(C)=O)[C@@H](C)C[C@H]6NC7=CC=C(Cl)C=C7 |
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