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Nemorubicin是一种抗癌药物，IC50值为0.08 uM。它对抗烷化剂，拓扑异构酶II抑制剂和铂衍生物具有抗性的肿瘤具有活性。它主要通过抑制拓扑异构酶I起作用。
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 15.54 mL | 77.68 mL | 155.37 mL |
| 0.5 mM | 3.11 mL | 15.54 mL | 31.07 mL |
| 1 mM | 1.55 mL | 7.77 mL | 15.54 mL |
| 5 mM | 0.31 mL | 1.55 mL | 3.11 mL |
*The above data is based on the productmolecular weight 643.64. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A14363 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 643.64 |
| Formula | C32H37NO13 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 108852-90-0 |
| Synonyms | PNU152243A, PNU-152243A, PNU 152243A, Nemorubicin, methoxymorpholinyl-doxorubicin |
| SMILES | O=C1C2=C(O)C(C[C@](C(CO)=O)(O)C[C@@H]3O[C@H]4C[C@H](N5C[C@@H](OC)OCC5)[C@H](O)[C@H](C)O4)=C3C(O)=C2C(C6=C1C=CC=C6OC)=O |
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