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NKL 22 is a HDAC inhibitor. The value of IC 50 is 78 uM NKL 22 increase frataxin protein concentrations NKL 22 inhibitors increase FXN mRNA in FRDA lymphocytes. HDAC inhibitors act directly on FXN.
| In vitro | DMSO | 62 mg/mL (190.53 mM) | |
| Water | Insoluble | ||
| Ethanol | 3 mg/mL (9.21 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 30.73 mL | 153.66 mL | 307.31 mL |
| 0.5 mM | 6.15 mL | 30.73 mL | 61.46 mL |
| 1 mM | 3.07 mL | 15.37 mL | 30.73 mL |
| 5 mM | 0.61 mL | 3.07 mL | 6.15 mL |
*The above data is based on the productmolecular weight 325.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A20600 |
|---|---|
| M. Wt | 325.4 |
| Formula | C19H23N3O2 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 537034-15-4 |
| Synonyms | NKL22, NKL-22 |
| SMILES | O=C(NC1=CC=CC=C1N)CCCCCC(NC2=CC=CC=C2)=O |
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