NU7026

Name: NU7026
SKU: A12752

目录号: A12752

DNA-PK 抑制剂

Product Citations (1)

NU7026 Chemical Structure

CAS NO. 154447-35-5

NU7026是一种新型的在无细胞试验中IC50为0.23 μM，作用于DNA-PK比作用于PI3K选择性高60倍，对ATM和ATR没有抑制活性。可增强用于治疗白血病的拓扑异构酶II毒物的细胞毒性。

库存：现货

规格	价格	数量
10 mg	￥ 350.00
25 mg	￥ 700.00
50 mg	￥ 1,120.00
100 mg	￥ 1,960.00

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产品详情

生物活性

靶点信息

DNA-PK (Cell-free assay)	PI3K (Cell-free assay)	ATM (Cell-free assay)	ATR (Cell-free assay)
0.23 μM	13 μM	>100 μM	>100 μM

溶解度 *

In vitro (25°C)	DMSO	1 mg/mL (3.55 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	1% DMSO+30% polyethylene glycol+1% Tween 80	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	35.55 mL	177.74 mL	355.48 mL
0.5 mM	7.11 mL	35.55 mL	71.1 mL
1 mM	3.55 mL	17.77 mL	35.55 mL
5 mM	0.71 mL	3.55 mL	7.11 mL

*The above data is based on the productmolecular weight 281.31. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A12752
作用机制	Inhibitor (抑制剂)
M. Wt	281.31
Formula	C17H15NO3
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	154447-35-5
Synonyms	NU 7026, NU-7026
SMILES	C1COCCN1C2=CC(=O)C3=C(O2)C4=CC=CC=C4C=C3