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PCI-34051是一种有效的特异性组蛋白脱乙酰基酶8（HDAC8）抑制剂，其选择性是其他HDAC亚型的200倍以上。
Targets
| Target | Value |
|---|---|
| HDAC8 | IC50: 10nM |
| HDAC6 | IC50: 2.9μM |
| HDAC1 | IC50: 4μM |
| HDAC10 | IC50: 13μM |
| HDAC2 | IC50: >50μM |
| HDAC3 | IC50: >50μM |
| In vitro (25°C) | DMSO | 58 mg/mL (195.73 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
| In vivo | 5% DMSO+40%PEG300+5% tween80+50% H2O | 4 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 33.75 mL | 168.75 mL | 337.5 mL |
| 0.5 mM | 6.75 mL | 33.75 mL | 67.5 mL |
| 1 mM | 3.37 mL | 16.87 mL | 33.75 mL |
| 5 mM | 0.67 mL | 3.37 mL | 6.75 mL |
*The above data is based on the productmolecular weight 296.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A11152 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 296.3 |
| Formula | C17H16N2O3 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 950762-95-5 |
| Synonyms | PCI34051 |
| SMILES | COC1=CC=C(C=C1)CN2C=CC3=C2C=C(C=C3)C(=O)NO |
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