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PF-06751979 is a potent, brain penetrant, β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor with an IC50 of 7.3 nM in BACE1 binding assay.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 21.95 mL | 109.77 mL | 219.54 mL |
| 0.5 mM | 4.39 mL | 21.95 mL | 43.91 mL |
| 1 mM | 2.2 mL | 10.98 mL | 21.95 mL |
| 5 mM | 0.44 mL | 2.2 mL | 4.39 mL |
*The above data is based on the productmolecular weight 455.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A20066 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 455.5 |
| Formula | C18H19F2N5O3S2 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1818339-66-0 |
| Synonyms | PF 06751979, PF06751979 |
| SMILES | FC(F)OC1=CN=C(C(NC2=CSC([C@]34CO[C@@H](C)C[C@@]3([H])CSC(N)=N4)=N2)=O)C=C1 |
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