PF 4708671

Name: PF 4708671
SKU: A11755

目录号: A11755

S6 kinase 抑制剂

Product Citations (1)

PF 4708671 Chemical Structure

CAS NO. 1255517-76-0

PF 4708671是p70核糖体S6激酶（S6K1）的高度特异性抑制剂，可抑制S6K1介导的IGF-1磷酸化S6蛋白的磷酸化，而对高度相关的RSK和MSK激酶没有影响。

库存：现货

规格	价格	数量
10 mg	￥ 420.00
25 mg	￥ 840.00
50 mg	￥ 1,400.00
100 mg	￥ 2,450.00
10mM * 1mL in DMSO	￥ 574.00

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生物活性

PF 4708671是p70核糖体S6激酶（S6K1）的高度特异性抑制剂，可抑制S6K1介导的IGF-1磷酸化S6蛋白的磷酸化，而对高度相关的RSK和MSK激酶没有影响。

靶点信息

p70 S6K1 (Cell-free assay)
160 nM

溶解度 *

In vitro (25°C)	DMSO	30 mg/mL (76.84 mM)
	Water	Insoluble
	Ethanol	8 mg/mL (20.49 mM)
In vivo	30% PEG400+0.5% Tween80+5% propylene glycol	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	25.61 mL	128.07 mL	256.15 mL
0.5 mM	5.12 mL	25.61 mL	51.23 mL
1 mM	2.56 mL	12.81 mL	25.61 mL
5 mM	0.51 mL	2.56 mL	5.12 mL

*The above data is based on the productmolecular weight 390.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A11755
作用机制	Inhibitor (抑制剂)
M. Wt	390.4
Formula	C19H21F3N6
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	1255517-76-0
Synonyms	PF4708671, PF-4708671
SMILES	CCC1=CN=CN=C1N2CCN(CC2)CC3=NC4=C(N3)C=C(C=C4)C(F)(F)F