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PF-4989216是一种有效的选择性PI3K抑制剂，对p110α，p110β，p110γ，p110δ和VPS34的IC50分别为2 nM，142 nM，65 nM，1 nM和110 nM。
靶点信息
| p110δ | p110α | p110γ | Vps34 | p110β |
| 1 nM | 2 nM | 65 nM | 110 nM | 142 nM |
| In vitro (25°C) | DMSO | 66 mg/mL (173.49 mM) | |
| Water | Insoluble | ||
| Ethanol | Warmed: 6 mg/mL (15.77 mM) | ||
| In vivo | Suspended in 0.5% methylcellulose | 1 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 26.29 mL | 131.44 mL | 262.88 mL |
| 0.5 mM | 5.26 mL | 26.29 mL | 52.58 mL |
| 1 mM | 2.63 mL | 13.14 mL | 26.29 mL |
| 5 mM | 0.53 mL | 2.63 mL | 5.26 mL |
*The above data is based on the productmolecular weight 380.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A12889 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 380.4 |
| Formula | C18H13FN6OS |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1276553-09-3 |
| Synonyms | PF4989216, PF 4989216 |
| SMILES | C1COCCN1C2=C(C(=C(S2)C3=NC=NN3)C4=C(C=C(C=C4)C#N)F)C#N |
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