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PFI-2是一种有效的，选择性的，具有细胞活性的赖氨酸甲基转移酶SETD7抑制剂，Ki（app）和IC50为0.33 nM和2 nM，选择性是其他甲基转移酶和其他非表观遗传靶标的1000倍。
靶点信息
| SETD7 | SETD7 | |||
| 0.33 nM(Ki) | 2 nM |
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 20.02 mL | 100.1 mL | 200.19 mL |
| 0.5 mM | 4 mL | 20.02 mL | 40.04 mL |
| 1 mM | 2 mL | 10.01 mL | 20.02 mL |
| 5 mM | 0.4 mL | 2 mL | 4 mL |
*The above data is based on the productmolecular weight 499.52. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A14216 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 499.52 |
| Formula | C23H25F4N3O3S |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1627676-59-8 |
| Synonyms | PFI2 |
| SMILES | C1CCN(C1)C(=O)[C@@H](CC2=CC(=CC=C2)C(F)(F)F)NS(=O)(=O)C3=CC(=C4CNCCC4=C3)F |
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