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PI-103 Hydrochloride是对重组PI3K亚型p110alpha（IC50 = 2 nM），p110beta（IC50 = 3 nM），p110delta（IC50 = 3 nM）和p110gamma（IC50 = 15 nM）具有低IC50值的有效抑制剂，对mTOR的效力较低/DNA-PK，IC50为30 nM/23 nM。
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 25.99 mL | 129.93 mL | 259.86 mL |
| 0.5 mM | 5.2 mL | 25.99 mL | 51.97 mL |
| 1 mM | 2.6 mL | 12.99 mL | 25.99 mL |
| 5 mM | 0.52 mL | 2.6 mL | 5.2 mL |
*The above data is based on the productmolecular weight 384.82. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A15212 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 384.82 |
| Formula | C19H17ClN4O3 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 371935-79-4 |
| Synonyms | PI 103 hydrochloride, PI103 hydrochloride |
| SMILES | C1COCCN1C2=NC(=NC3=C2OC4=C3C=CC=N4)C5=CC(=CC=C5)O.Cl |
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