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Picropodophyllin是首个靶向口服小分子igf-1受体抑制剂，IC50为1 nM。对胰岛素受体无影响。
靶点信息
| IGF-1R | ||||
| 1 nM |
| In vitro | DMSO | Warmed: 79 mg/mL (190.63 mM) | |
| Water | Insoluble | ||
| Ethanol | Warmed: 1 mg/mL | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 24.13 mL | 120.66 mL | 241.31 mL |
| 0.5 mM | 4.83 mL | 24.13 mL | 48.26 mL |
| 1 mM | 2.41 mL | 12.07 mL | 24.13 mL |
| 5 mM | 0.48 mL | 2.41 mL | 4.83 mL |
*The above data is based on the productmolecular weight 414.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A12195 |
|---|---|
| M. Wt | 414.4 |
| Formula | C22H22O8 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 477-47-4 |
| Synonyms | AXL1717, AX-L1717, AXL 1717 |
| SMILES | COC1=CC(=CC(=C1OC)OC)[C@H]2[C@H]3[C@H](COC3=O)[C@H](C4=CC5=C(C=C24)OCO5)O |
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