PIK-75 hydrochloride

Name: PIK-75 hydrochloride
SKU: A10729

目录号: A10729

PI3K 抑制剂

Product Citations (1)

PIK-75 hydrochloride Chemical Structure

CAS NO. 372196-77-5

PIK-75是一种p110α抑制剂，IC50值为5.8nM。在p110γ和p110β的效果较差，IC50值为0.076 ?M和1.3 ?M。

库存：现货

规格	价格	数量
10 mg	￥ 280.00
25 mg	￥ 490.00
50 mg	￥ 840.00
100 mg	￥ 1,190.00

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生物活性

PIK-75是一种p110α抑制剂，IC50值为5.8nM。在p110γ和p110β的效果较差，IC50值为0.076 ?M和1.3 ?M。

靶点信息

DNA-PK (Cell-free assay)	p110α (Cell-free assay)	p110γ (Cell-free assay)	p110δ (Cell-free assay)	p110β (Cell-free assay)
2 nM	5.8 nM	76 nM	0.51 μM	1.3 μM

溶解度 *

In vitro	DMSO	Warmed: 4 mg/mL (8.18 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	20.46 mL	102.31 mL	204.62 mL
0.5 mM	4.09 mL	20.46 mL	40.92 mL
1 mM	2.05 mL	10.23 mL	20.46 mL
5 mM	0.41 mL	2.05 mL	4.09 mL

*The above data is based on the productmolecular weight 488.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A10729
作用机制	Inhibitor (抑制剂)
M. Wt	488.7
Formula	C16H14BrN5O4S.HCl
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	372196-77-5
Synonyms	PIK75
SMILES	CC1=C(C=C(C=C1)[N+](=O)[O-])S(=O)(=O)N(C)/N=C/C2=CN=C3N2C=C(C=C3)Br.Cl