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PIK-93是第一个有效的，人工合成的PI4K(PI4KIIIβ)抑制剂，IC50为19 nM；抑制PI3Kα，IC50为39 nM。
Targets
| Target | Value |
|---|---|
| p110γ | IC50: 16nM |
| PI4KIIIβ | IC50: 19nM |
| p110α | IC50: 39nM |
| DNA-PK | IC50: 64nM |
| p110δ | IC50: 120nM |
| C2β | IC50: 140nM |
| hsVps34 | IC50: 320nM |
| ATM | IC50: 490nM |
| p110β | IC50: 590nM |
| PI4KIIIα | IC50: 1.1μM |
| mTORC1 | IC50: 1.38μM |
| C2α | IC50: 16μM |
| ATR | IC50: 17μM |
| PI4KIIα | IC50: >100μM |
| PI4P5KIα | IC50: >100μM |
| PI4P5KIβ | IC50: >100μM |
| PI5P4KIIβ | IC50: >100μM |
| In vitro (25°C) | DMSO | 69 mg/mL (176.98 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
| In vivo | 30% PEG400+0.5% Tween80+5% propylene glycol | 28 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 25.65 mL | 128.24 mL | 256.48 mL |
| 0.5 mM | 5.13 mL | 25.65 mL | 51.3 mL |
| 1 mM | 2.56 mL | 12.82 mL | 25.65 mL |
| 5 mM | 0.51 mL | 2.56 mL | 5.13 mL |
*The above data is based on the productmolecular weight 389.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A10731 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 389.9 |
| Formula | C14H16ClN3O4S2 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 593960-11-3 |
| Synonyms | PIK93 |
| SMILES | CC1=C(SC(=N1)NC(=O)C)C2=CC(=C(C=C2)Cl)S(=O)(=O)NCCO |
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