Posaconazole

Name: Posaconazole
SKU: A10744

目录号: A10744

CYP3A4 抑制剂

Posaconazole Chemical Structure

CAS NO. 171228-49-2

Posaconazole主要是CYP3A4的抑制剂，但不抑制其他CYP酶的活性。也是甾醇C14+脱甲基酶抑制剂的抑制剂，IC50为0.25μM。泊沙康唑的终末消除半衰期中位数为15-35小时。

库存：现货

规格	价格	数量
5 mg	￥ 420.00
10 mg	￥ 700.00
25 mg	￥ 1,260.00
50 mg	￥ 2,100.00
10mM * 1mL in DMSO	￥ 1,001.00

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产品详情

生物活性

靶点信息

lanosterol 14α-demethylase

溶解度 *

In vitro (25°C)	DMSO	90 mg/mL (128.42 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	1% DMSO+30% polyethylene glycol+1% Tween 80	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	14.27 mL	71.35 mL	142.69 mL
0.5 mM	2.85 mL	14.27 mL	28.54 mL
1 mM	1.43 mL	7.13 mL	14.27 mL
5 mM	0.29 mL	1.43 mL	2.85 mL

*The above data is based on the productmolecular weight 700.8 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A10744
作用机制	Inhibitor (抑制剂)
M. Wt	700.8
Formula	C37H42F2N8O4
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	171228-49-2
Synonyms	Noxafil
SMILES	CC[C@@H]([C@H](C)O)N1C(=O)N(C=N1)C2=CC=C(C=C2)N3CCN(CC3)C4=CC=C(C=C4)OC[C@H]5C[C@](OC5)(CN6C=NC=N6)C7=C(C=C(C=C7)F)F