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Poseltinib, an orally active, selective and irreversible Bruton??s tyrosine kinase (BTK) inhibitor (IC50 =1.95 nM), with 0.3, 2.3 and 2.4-fold selectivity for BTK over BMX, TEC and TXK, respectively.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 21.25 mL | 106.27 mL | 212.53 mL |
| 0.5 mM | 4.25 mL | 21.25 mL | 42.51 mL |
| 1 mM | 2.13 mL | 10.63 mL | 21.25 mL |
| 5 mM | 0.43 mL | 2.13 mL | 4.25 mL |
*The above data is based on the productmolecular weight 470.52. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A19450 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 470.52 |
| Formula | C26H26N6O3 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1353552-97-2 |
| Synonyms | HM 71224, HM-71224, LY-333764, LY 33376411 |
| SMILES | O=C(C=C)NC1=CC=CC(OC2=C(OC=C3)C3=NC(NC4=CC=C(N5CCN(C)CC5)C=C4)=N2)=C1 |
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