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Potassium Channels

38 个项目

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  1. ML277
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    ML277

    Catalog No. A21749
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    KCNQ1 potassium channel activator
    ML277(CID53347902) is a novel, potent and selective K(v)7.1 (KCNQ1) potassium channel activator with EC50 of 270 nM. 了解更多
  2. VU591
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    VU591

    Catalog No. A21362
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    potassium channel inhibitor
    VU591 is a potent, selective renal outer medullary potassium channel (ROMK or Kir1.1) inhibitor, with an IC50 of 0.24 μM. 了解更多
  3. Cisapride
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    Cisapride

    Catalog No. A21340
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    hERG potassium channel inhibitor
    Cisapride(R 51619) is a nonselective 5-HT4 receptor agonist, it is also a potent hERG potassium channel inhibitor. 了解更多
  4. Digoxin
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    Digoxin

    Catalog No. A14242
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    sodium-potassium pump 抑制剂
    Digoxin是Na+/K+-ATPase 的有效抑制剂 了解更多
  5. KB130015
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    KB130015

    Catalog No. A15493
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    hERG1 potassium channel activator
    KB130015是hERG1钾离子通道的新型激活剂，可在高压下阻断天然和重组hERG1通道，但在低压下激活它们。 了解更多
  6. ICA-110381
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    ICA-110381

    Catalog No. A15503
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    KV7.2/7.3 activator
    ICA-110381是KV7.2/7.3激活剂，EC50为0.38 uM。 了解更多
  7. NS-1643
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    NS-1643

    Catalog No. A15929
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    hERG channel activator
    NS-1643是一种人类以太相关基因（hERG）KV11.1通道激活剂（EC50 = 10.5 uM）。 了解更多
  8. NS1619
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    NS1619

    Catalog No. A15975
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    Potassium channel activator
    NS1619是Bkca开启剂或大电导Ca2+激活的钾（BKCa，KCa1.1）通道激活剂。 了解更多
  9. Doxapram
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    Doxapram

    Catalog No. A15961
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    Doxapram能抑制TASK-1，TASK-3，TASK-1/TASK-3异二聚体通道功能，EC50分别为410 nM，37μM，9μM。Doxapram是一种呼吸刺激剂。静脉注射多沙普兰可刺激潮气量和呼吸频率的增加。 了解更多
  10. K+ Channel inhibitor
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    K+ Channel inhibitor

    Catalog No. A16182
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    K+ Channel 抑制剂
    K+ Channel inhibitor，Kv1.5（IKur）的二氢吡唑并嘧啶抑制剂的合成基础。 了解更多
  11. Cesium chloride
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    Cesium chloride

    Catalog No. A15341
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    Potassium channel blocker
    Cesium chloride是钾通道阻滞剂。抑制起搏器电流（If）和超极化激活的阳离子电流（Ih）。通过灭活GSK-3β来防止血清和钾缺乏的小脑颗粒神经元中caspase-3的激活和神经元凋亡。 了解更多
  12. SKA-31
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    • 最新产品

    SKA-31

    Catalog No. A17117
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    potassium channel activator
    SKA-31是KCa2和KCa3.1钙激活钾通道的激活剂。 了解更多
  13. 4-Aminopyridine
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    4-Aminopyridine

    Catalog No. A17490
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    Potassium channel blocker
    Dalfampridine is a potassium channel blocker used to help multiple sclerosis patients walk. 了解更多
  14. AUT1
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    AUT1

    Catalog No. A18648
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    Kv3 potassium channel modulator
    AUT1 is a Kv3 potassium channel modulator with pEC50s of 5.33 and 5.31 for human recombinant Kv3.1b and Kv3.2a, respectively, exhibits 10-fold lower potency at human recombinant Kv3.3 channel (pEC50, 4.5). 了解更多
  15. ML418
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    ML418

    Catalog No. A18426
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    Kir7.1 potassium channels blocker
    ML418 is a selective, sub-micromolar pore blocker of Kir7.1 potassium channels. The inward rectifier potassium (Kir) channel Kir7.1 (KCNJ13) is a key regulator of melanocortin signaling in the brain, electrolyte homeostasis in the eye, and uterine muscle contractility during pregnancy. 了解更多
  16. Y-26763
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    Y-26763

    Catalog No. A12271
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    K+ (KATP) channel activator
    Y-26763 is a K+ channel opener and active metabolite of Y-27152. Y-26763 is an ATP-sensitive K+ (KATP) channel activator. 了解更多
  17. JNJ 303
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    JNJ 303

    Catalog No. A20952
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    IKs blocker
    JNJ 303 is a potent IKs blocker with an IC50 value of 64 nM. 了解更多
  18. RPR-260243
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    RPR-260243

    Catalog No. A20977
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    HERG activator
    RPR-260243 is a novel activator of HERG; modifies HERG currents inhibited by dofetilide (IC50 = 58 nM); little effect on HERG current amplitude and no significant effects on steady-state activation parameters or on channel inactivation processes. 了解更多
  19. MK-7145
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    MK-7145

    Catalog No. A21030
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    ROMK inhibitor
    MK-7145 is a ROMK inhibitor, with an IC50 of 0.045 μM. 了解更多
  20. TAK-438 (vonoprazan)
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    TAK-438 (vonoprazan)

    Catalog No. A11239
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    potassium-competitive acid Blocker
    TAK-438 (vonoprazan)是一种新型的钾竞争酸阻滞剂。 了解更多
  21. Orphenadrine citrate
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    Orphenadrine citrate

    Catalog No. A11712
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    NMDA receptor 拮抗剂
    Orphenadrine柠檬酸盐是NMDA受体拮抗剂，Ki为6.0μM，还是HERG钾离子通道阻断剂。 了解更多
  22. NS 309
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    NS 309

    Catalog No. A11934
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    KCa3.1 channel activator
    NS 309是小和中电导Ca2+激活的K+通道（KCa2和KCa3.1通道）的正调制器。 了解更多
  23. Glimepiride
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    Glimepiride

    Catalog No. A10430
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    Kir6.2/SUR 抑制剂
    Glimepiride是一种强效Kir6.2/SUR抑制剂，SUR1、SUR2A和SURB的IC50分别为3.0 nM、5.4 nM和7.3 nM，用于治疗2型糖尿病化合物。 了解更多
  24. Retigabine (Ezogabine)
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    Retigabine (Ezogabine)

    Catalog No. A11922
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    Retigabine是一种新型的抗痉挛剂，在大范围的惊厥模型具有活性。其发挥活性的机制主要是开放神经元的KCNQ2-5电压门控钾离子通道。 了解更多
  25. Hydralazine hydrochloride
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    Hydralazine hydrochloride

    Catalog No. A10455
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    Hydralazine hydrochloride是肼屈嗪的盐酸盐(安普索林)，是一种直接作用的平滑肌松弛剂，IC50为1.9 mM。 了解更多
  26. Minoxidil (U-10858)
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    Minoxidil (U-10858)

    Catalog No. A10593
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    Minoxidil (U-10858)是一种选择性的ATP依赖性K+(Kir6)通道激活剂。 了解更多
  27. Nateglinide (Starlix)
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    Nateglinide (Starlix)

    Catalog No. A10629
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    Nateglinide(Starlix)是一种胰岛素促分泌剂，可通过刺激胰腺分泌胰岛素来降低血糖水平。 了解更多
  28. Mitiglinide calcium
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    Mitiglinide calcium

    Catalog No. A11884
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    KATP channel 拮抗剂
    Mitiglinide calcium是一种降血糖药物，通过关闭胰腺β细胞中的ATP敏感K+通道来刺激胰岛素分泌。 了解更多
  29. PAP-1 (5-(4-Phenoxybutoxy)psoralen)
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    PAP-1 (5-(4-Phenoxybutoxy)psoralen)

    Catalog No. A11521
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    Kv1.3 blocker
    PAP-1 (5-(4-Phenoxybutoxy)psoralen) 是一种有效的，选择性的，口服活性的?Kv1.3?阻滞剂 (EC50=2 nM)。PAP-1 以使用依赖性方式阻止 Kv1.3，并通过优先绑定到通道的 C 型灭活状态来起作用。 了解更多
  30. TRAM-34
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    TRAM-34

    Catalog No. A12783
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    Potassium Channel Blocker
    TRAM-34是中等电导Ca2+激活的K+通道（KCa3.1）（Kd = 20 nM）的高度选择性阻滞剂。在KV，BKCa，KCa2，Na+，CRAC和Cl-通道上具有200-1500倍的选择性。抑制有丝分裂刺激对淋巴细胞的激活。 了解更多
  31. E-4031 dihydrochloride
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    E-4031 dihydrochloride

    Catalog No. A12857
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    K+ channel blocker?
    E-4031 dihydrochloride是KV11.1（hERG）通道的选择性阻滞剂；禁止快速延迟整流器K+电流（IKr）。 了解更多
  32. Glyburide
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    Glyburide

    Catalog No. A10433
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    K+ channel and CFTR Cl- channel blocker
    Glyburide (Glibenclamide) 是一种抗糖尿病化合物，是一类磺脲类药物。 了解更多
  33. Nicorandil
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    Nicorandil

    Catalog No. A10641
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    Kir6 (KATP) channel opener
    Nicorandil (SG-75) 钾离子通道活化剂。 了解更多
  34. Repaglinide
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    Repaglinide

    Catalog No. A10783
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    Potassium Channel 抑制剂
    Repaglinide是一种有效的短效胰岛素促分泌剂，可通过关闭胰岛β细胞质膜中的ATP敏感性钾（KATP）通道发挥作用。 了解更多
  35. GW 542573X
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    GW 542573X

    Catalog No. A13944
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    KCa2.1 channels activator
    GW 542573X是小电导Ca2+激活的K+通道（KCa2）的激活剂。 了解更多
  36. 20-HETE
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    20-HETE

    Catalog No. A14971
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    20-HETE是在血管平滑肌（VSM）细胞中产生的有效血管收缩剂。 了解更多
  37. Retigabine dihydrochloride
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    Retigabine dihydrochloride

    Catalog No. A15222
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    KCNQ channel opener
    Retigabine dihydrochloride是具有抗惊厥活性的Kv7.2-7.5（KCNQ2-5）神经元钾通道开放剂。 了解更多
  38. Vernakalant HCl
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    Vernakalant HCl

    Catalog No. A15275
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    Ion channel blocker
    Vernakalant hydrochloride是一种研究性混合离子通道阻滞剂，可以以2至5 mg/kg的剂量终止人的急性心房纤颤（AF），并且与现有药物相比，对房颤的选择性更高。在抗心律不齐的治疗中。 了解更多

38 个项目

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  1. Inhibitor (抑制剂) (8)
  2. Antagonist (拮抗剂) (2)
  3. Activator (激活剂) (11)
  4. Modulator (调节剂) (1)
  5. Blocker (阻断剂) (11)
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