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Poziotinib是一种口服生物利用的，基于喹唑啉的泛表皮生长因子受体（EGFR或HER）抑制剂，具有潜在的抗肿瘤活性。
靶点信息
| HER1 | HER2 | HER4 | ||
| 3.2 nM | 5.3 nM | 23.5 nM |
| In vitro (25°C) | DMSO | 84 mg/mL (170.96 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
| In vivo | 2% DMSO+40% PEG 300+2% Tween 80+ddH2O | 4 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 20.35 mL | 101.76 mL | 203.53 mL |
| 0.5 mM | 4.07 mL | 20.35 mL | 40.71 mL |
| 1 mM | 2.04 mL | 10.18 mL | 20.35 mL |
| 5 mM | 0.41 mL | 2.04 mL | 4.07 mL |
*The above data is based on the productmolecular weight 491.34. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A13044 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 491.34 |
| Formula | C23H21Cl2FN4O3 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1092364-38-9 |
| Synonyms | HM781-36B, NOV120101, NOV-120101, NOV 120101 |
| SMILES | COC1=C(C=C2C(=C1)N=CN=C2NC3=C(C(=C(C=C3)Cl)Cl)F)OC4CCN(CC4)C(=O)C=C |
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