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Vernakalant HCl

Catalog No. A15275
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Ion channel blocker

Vernakalant hydrochloride是一种研究性混合离子通道阻滞剂，可以以2至5 mg/kg的剂量终止人的急性心房纤颤（AF），并且与现有药物相比，对房颤的选择性更高。在抗心律不齐的治疗中。了解更多

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- Joe Z.Zhang, .et al. A Human iPSC Double-Reporter System Enables Purification of Cardiac Lineage Subpopulations with Distinct Function and Drug Response Profiles, Cell Stem Cell, 2019, 24, 1-10
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Bisoprolol fumarate

Catalog No. A10149
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β1 adrenergic receptor blocker

Bisoprolol fumarate是一种属于β受体阻滞剂的药物，β受体阻滞剂是一类主要用于心血管疾病的药物。更具体地说，它是一种选择性的β1肾上腺素能受体阻滞剂。了解更多

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Orphenadrine citrate

Catalog No. A11712
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NMDA receptor 拮抗剂

Orphenadrine柠檬酸盐是NMDA受体拮抗剂，Ki为6.0μM，还是HERG钾离子通道阻断剂。了解更多

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Glyburide

Catalog No. A10433
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K+ channel and CFTR Cl- channel blocker

Glyburide (Glibenclamide) 是一种抗糖尿病化合物，是一类磺脲类药物。了解更多

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Gap 27

Catalog No. A14866
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Gap junction blocker

Gap 27是衍生自连接蛋白43的肽，其是选择性的间隙连接阻断剂。了解更多

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Amiloride HCl

Catalog No. A10064
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Na+ channel blocker

Amiloride HCl是一种Na+通道阻滞剂，还抑制TRPP3通道和Na+/H+交换剂（NHE）。了解更多

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- Yu Y, .et al. Expression, Localization and Functional Activity of the Major Na+/H+ Exchange Isoforms Expressed in the Intestinal Cell Line Caco-2BBe, Cell Physiol Biochem, 2019, 52(5):1017-1038 PMID: 30977986
- Thomas D. Williams, .et al. The physiological regulation of macropinocytosis during Dictyostelium growth and development, J Cell Sci, 2018, Mar 15; 131(6): jcs213736 PMID: 29440238
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Azilsartan (TAK-536)

Catalog No. A11775
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AT1 Receptor Blocker

Azilsartan (TAK-536)是一种用于治疗高血压的血管紧张素II受体拮抗剂。了解更多

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PAP-1 (5-(4-Phenoxybutoxy)psoralen)

Catalog No. A11521
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Kv1.3 blocker

PAP-1 (5-(4-Phenoxybutoxy)psoralen) 是一种有效的，选择性的，口服活性的?Kv1.3?阻滞剂 (EC50=2 nM)。PAP-1 以使用依赖性方式阻止 Kv1.3，并通过优先绑定到通道的 C 型灭活状态来起作用。了解更多

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- Samuel Drinkall, .et al. The two pore potassium channel THIK-1 regulates NLRP3 inflammasome activation, Glia, 2022, Jul;70(7):1301-1316 PMID: 35353387
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TCS 5861528

Catalog No. A14126
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TRPA1 channel blocker

TCS 5861528是TRPA1通道阻滞剂和AITC和4-HNE诱发的钙流入的拮抗剂。了解更多

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Cilnidipine

Catalog No. A10215
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Calcium channel blocker

Cilnidipine是提供血管平滑肌中L型电压门控钙通道和交感神经末梢N型钙通道的双重阻滞剂。了解更多

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Clevidipine

Catalog No. A11746
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Calcium channel blocker

Clevidipine是一种二氢吡啶类钙通道阻滞剂，用于在口服治疗不可行或不理想时降低血压。了解更多

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Nifedipine

Catalog No. A10643
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L-type calcium channel blocker.

Nifedipine是一种L型钙通道阻滞剂。了解更多

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NP118809

Catalog No. A15192
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N-type calcium channel blocker

NP118809是有效的N型钙通道阻滞剂（IC50 = 0.11 uM）；对L型钙通道的选择性好。了解更多

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Amlodipine

Catalog No. A10068
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L-type calcium channel blocker

Amlodipine是一种L型钙通道阻滞剂，具有降压作用。它抑制去极化大鼠主动脉中Ca2 +诱导的收缩（IC50 = 1.9 nM），并在心血管疾病中显示出血管保护作用。了解更多

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TAK-438 (vonoprazan)

Catalog No. A11239
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potassium-competitive acid Blocker

TAK-438 (vonoprazan)是一种新型的钾竞争酸阻滞剂。了解更多

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TRAM-34

Catalog No. A12783
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Potassium Channel Blocker

TRAM-34是中等电导Ca2+激活的K+通道（KCa3.1）（Kd = 20 nM）的高度选择性阻滞剂。在KV，BKCa，KCa2，Na+，CRAC和Cl-通道上具有200-1500倍的选择性。抑制有丝分裂刺激对淋巴细胞的激活。了解更多

Product Citations (2)

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- Samuel Drinkall, .et al. The two pore potassium channel THIK-1 regulates NLRP3 inflammasome activation, Glia, 2022, Jul;70(7):1301-1316 PMID: 35353387
- Cheong Hoon Seo, .et al. Altered K Ca 3.1 expression following burn injury and the therapeutic potential of TRAM-34 in post-burn hypertrophic scar formation, Transl Res, 2021, Apr 24 PMID: 33905948
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Berbamine

Catalog No. A14794
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Calcium channel blocker

Berbamine是钙通道阻滞剂。了解更多

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A 803467

Catalog No. A11234
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Sodium channel Blocker

A 803467是NaV1.8通道的选择性阻滞剂（hNaV1.8，hNaV1.3，hNaV1.7，hNaV1.5和hNaV1.2通道的IC50值分别为8、2450、6740、7340和7380 nM）。了解更多

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Isradipine

Catalog No. A10487
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calcium channel blocker

伊拉地平是二氢吡啶类钙通道阻滞剂。了解更多

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- Deborah A. Goldspink, .et al. Mechanistic insights into the detection of free fatty and bile acids by ileal glucagon-like peptide-1 secreting cells, Mol Metab, 2018, Jan; 7: 90-101 PMID: 29167062
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A 967079

Catalog No. A12353
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TRPA1 channel blocker

A 967079是选择性TRPA1通道阻滞剂(人和大鼠TRPA1受体的IC50值分别为67和289 nM)。了解更多

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- L Jin, .et al. Acrolein but not its metabolite, 3-Hydroxypropylmercapturic acid (3HPMA), activates vascular transient receptor potential Ankyrin-1 (TRPA1): Physiological to toxicological implications, Toxicol Appl Pharmacol, 2021, Jul 13;426:115647 PMID: 34271065
- L. Jin, .et al. Crotonaldehyde-induced vascular relaxation and toxicity: Role of endothelium and transient receptor potential ankyrin-1 (TRPA1), Toxicology and Applied Pharmacology, 2020, 398(1),
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QX 314 chloride

Catalog No. A13760
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Sodium channel Blocker

QX 314 chloride是利多卡因的膜不可渗透的季衍生物，一种电压激活的Na+通道阻滞剂。了解更多

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