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Entecavir hydrate

Catalog No. A11216
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Reverse transcriptase 抑制剂

Entecavir hydrate，一个新的脱氧鸟嘌呤核苷类似物，是乙肝病毒复制的选择性抑制剂。了解更多

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- Masaaki Toyama, .et al. Novel Neplanocin A Derivatives as Selective Inhibitors of Hepatitis B Virus with a Unique Mechanism of Action, Antimicrob Agents Chemother, 2022, Jun 21;66(6) PMID: 35604213
- Toyama M, .et al. Pyrimidotriazine derivatives as selective inhibitors of HBV capsid assembly, Virus Res, 2019, Oct 2;271:197677 PMID: 31376401
- Kazumoto Murata, .et al. Induction of IFN-λ3 as an additional effect of nucleotide, not nucleoside, analogues: a new potential target for HBV infection, Gut, 2018, Feb; 67(2): 362-371 PMID: 27789659
- Jianfei L, .et al. The Ca2+/CaMKK2 axis mediates the telbivudine induced upregulation of creatine kinase: Implications for mechanism of antiviral nucleoside analogs' side effect, Biochem Pharmacol, 2017, Dec 15;146:224-232 PMID: 29038020
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Kenpaullone

Catalog No. A11220
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CDK 抑制剂

Kenpaullone是CDK1/细胞周期蛋白B（IC 50 = 400 nM），CDK2/细胞周期蛋白A（IC 50 = 680nM），CDK5（IC 50 = 850nM）的有效抑制剂，对其他激酶的作用要小得多。了解更多

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- Katelyn M Green, .et al. High-throughput screening yields several small-molecule inhibitors of repeat-associated non-AUG translation, J Biol Chem, 2019, jbc.RA119.009951
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Febuxostat (TEI-6720)

Catalog No. A10382
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xanthine oxidase 抑制剂

Febuxostat (TEI-6720)是黄嘌呤氧化酶的非嘌呤抑制剂（Ki = 1.2 nM）。了解更多

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PD 169316

Catalog No. A11221
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p38 MAPK 抑制剂

PD 169316 (PD169316)是p38 MAPK.1的选择性抑制剂，可抑制p38 MAPK，IC50为89 nM。了解更多

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TWS119

Catalog No. A11223
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GSK-3 抑制剂

TWS119是4,6双取代的吡咯并嘧啶，可有效抑制GSK3β，IC50值为30 nM。了解更多

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PF 429242

Catalog No. A11230
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SREBP 抑制剂

PF 429242是固醇调节元件结合蛋白（SREBP）位点1蛋白酶的可逆竞争性抑制剂。了解更多

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- Kai Xue, .et al. Advanced Oxidation Protein Product Promotes Oxidative Accentuation in Renal Epithelial Cells via the Soluble (Pro)renin Receptor-Mediated Intrarenal Renin-Angiotensin System and Nox4-H2O2 Signaling, Oxid Med Cell Longev, 2021, Nov 26;2021:5710440 PMID: 34873430
- Tong-bing Wang, .et al. SREBP1 site 1 protease inhibitor PF-429242 suppresses renal cell carcinoma cell growth, Cell Death Dis, 2021, Aug; 12(8): 717 PMID: 34285190
- Shiying Xie, .et al. Soluble (pro)renin receptor promotes fibrotic response in renal proximal tubule epithelial cells in vitro via Akt/β-catenin/Snail signaling pathway, Am J Physiol Renal Physiol, 2020, Aug 31 PMID: 32865015
- Yang PM, .et al. p38α/S1P/SREBP2 activation by the SAM-competitive EZH2 inhibitor GSK343 limits its anticancer activity but creates a druggable vulnerability in hepatocellular carcinoma, Am J Cancer Res, 2019, Oct 1;9(10):2120-2139 PMID: 31720078
- Hui Fang, .et al. (Pro)renin receptor mediates albumin-induced cellular responses: role of site-1 protease-derived soluble (pro)renin receptor in renal epithelial cells, Am J Physiol Cell Physiol, 2017, Dec 1; 313(6): C632-C643 PMID: 28903918
- Tsutomu Nakagawa, .et al. Site-1 protease is required for the generation of soluble (pro)renin receptor, J Biochem, 2016, Apr 1;161(4):369-379 PMID: 28013223
- Shimada S, .et al. Therapeutic effect of post-exposure treatment with antiserum on severe fever with thrombocytopenia syndrome (SFTS) in a mouse model of SFTS virus infection, Virology, 2015, Aug;482:19-27 PMID: 25817401
- Jan H. Reiling, .et al. A Luman/CREB3-ADP-ribosylation factor 4 (ARF4) signaling pathway mediates the response to Golgi stress and susceptibility to pathogens, Nat Cell Biol., 2013, 15(12): 1473-1485 PMID: 24185178
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PF 573228

Catalog No. A11235
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FAK 抑制剂

PF 573228是一种有效和选择性的粘着斑激酶（FAK）抑制剂（IC50 = 4 nM）。了解更多

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- Izumi D, .et al. CXCL12/CXCR4 activation by cancer-associated fibroblasts promotes integrin β1 clustering and invasiveness in gastric cancer, Int J Cancer, 2016, Mar 1;138(5):1207-19 PMID: 26414794
- Aya Yokota-Nakatsuma, .et al. Beta 1-integrin ligation and TLR ligation enhance GM-CSF-induced ALDH1A2 expression in dendritic cells, but differentially regulate their anti-inflammatory properties, Sci Rep, 2016, 6: 37914 PMID: 27897208
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Dovitinib Dilactic acid (TKI258 Dilactic acid)

Catalog No. A10198
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RTK 抑制剂

Dovitinib是一种小分子多靶点酪氨酸激酶抑制剂，可抑制通过ZNF198-FGFR1或BCR-FGFR1转化为IL3独立性的Ba / F3细胞，IC50值分别为150 nM和90 nM。了解更多

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β-Sitosterol

Catalog No. A11015
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5-alpha reductase 抑制剂

β-Sitosterol是一种植物甾醇，与胆固醇具有相似的化学结构。了解更多

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Rivaroxaban (Xarelto)

Catalog No. A10800
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Factor Xa 抑制剂

Rivaroxaban (Xarelto)是一种Factor Xa的直接抑制剂，无细胞试验中Ki和IC50分别为0.4 nM和0.7 nM。了解更多

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- Stefan Bittmann, .et al. TMPRSS2-Inhibitors Play a role in Cell Entry Mechanism of COVID-19: An Insight into Camostat and Nafamostat, J Regen Biol Med, 2020, 2(2):1-3
- Daniël Verhoef, .et al. Engineered factor Xa variants retain procoagulant activity independent of direct factor Xa inhibitors, Nat Commun, 2017, 8: 528 PMID: 28904343
- Mizuki Yamamoto, .et al. Identification of Nafamostat as a Potent Inhibitor of Middle East Respiratory Syndrome Coronavirus S Protein-Mediated Membrane Fusion Using the Split-Protein-Based Cell-Cell Fusion Assay, Antimicrob Agents Chemother, 2016, Nov; 60(11): 6532-6539 PMID: 27550352
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Camptothecin

Catalog No. A10174
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Topoisomerase I 抑制剂

Camptothecin是一种细胞毒性喹啉生物碱，可抑制DNA酶拓扑异构酶I（拓扑I）。了解更多

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FG-4592 (Roxadustat)

Catalog No. A11237
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HIF-PHs 抑制剂

FG-4592 (Roxadustat)是一种用于CKD贫血的新型缺氧诱导因子脯氨酰羟化酶抑制剂。了解更多

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- Singh C, .et al. Serine and 1-carbon metabolism are required for HIF-mediated protection against retinopathy of prematurity, JCI Insight, 2019, Jul 25;4(14) PMID: 31341109
- Hideaki Nakamura, .et al. Differentiated embryo chondrocyte plays a crucial role in DNA damage response via transcriptional regulation under hypoxic conditions, PLoS One, 2018, 13(2): e0192136 PMID: 29466367
- Singh C, .et al. 3-Hydroxypyruvate Destabilizes Hypoxia Inducible Factor and Induces Angiostasis, Invest Ophthalmol Vis Sci, 2018, Jul 2;59(8):3440-3448 PMID: 30025089
- George Hoppe, .et al. Comparative systems pharmacology of HIF stabilization in the prevention of retinopathy of prematurity, Proc Natl Acad Sci U S A, 2016, May 3; 113(18): E2516–E2525 PMID: 27091985
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Tenofovir Disoproxil Fumarate

Catalog No. A10909
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nucleotide reverse transcriptase 抑制剂

Tenofovir Disoproxil Fumarate属于一类抗逆转录病毒药物，其通过与天然底物脱氧腺苷5’-三磷酸盐竞争以及整合到DNA后终止DNA链抑制HIV reverse transcriptase活性。了解更多

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- Kazumoto Murata, .et al. Induction of IFN-λ3 as an additional effect of nucleotide, not nucleoside, analogues: a new potential target for HBV infection, Gut, 2018, Feb; 67(2): 362-371 PMID: 27789659
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Peramivir

Catalog No. A11124
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Neuraminidase 抑制剂

Peramivir是一种神经氨酸酶抑制剂，可作为流感神经氨酸酶的过渡态类似物抑制剂，从而防止新病毒从受感染的细胞中出现。了解更多

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- Daisuke Kato, .et al. An easy, rapid, and sensitive method for detection of drug-resistant influenza virus by using a sialidase fluorescent imaging probe, BTP3-Neu5Ac, PLoS One, 2018, 13(7): e0200761 PMID: 30001430
- Yuuki Kurebayashi, .et al. High-Efficiency Capture of Drug Resistant-Influenza Virus by Live Imaging of Sialidase Activity, PLoS One, 2016, 11(5): e0156400 PMID: 27232333
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Pneumocandin B0

Catalog No. A11113
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β-1,3-Glucan Synthase 抑制剂

Pneumocandin B0是脂肽家族的主要类似物，该脂肽家族是从几个不同属的几个物种中分离出来的，特别是隐孢子虫，Glarea和Pezicula。Pneumocandin B0是一种有效的抗真菌药，可通过抑制易感真菌细胞壁必不可少的成分β-（1,3）-D-葡聚糖的合成来发挥作用。了解更多

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Abacavir sulfate

Catalog No. A11120
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Transcriptase 抑制剂

Abacavir sulfate是一种核苷类似物逆转录酶抑制剂（NRTI）。了解更多

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Abacavir

Catalog No. A11115
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Transcriptase 抑制剂

Abacavir是一种核苷类似物逆转录酶抑制剂（NRTI）；鸟苷类似物用于治疗艾滋病毒和艾滋病。了解更多

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Chrysin

Catalog No. A10209
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Aromatase 抑制剂

Chrysin是从蓝色西番莲（Passiflora caerulea）中化学提取的天然黄酮。已经显示出诱导抗炎作用，最可能是通过抑制COX-2表达和通过IL-6信号传导。在啮齿动物体内研究中，发现了菊花素具有抗焦虑作用。了解更多

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Clofarabine

Catalog No. A10228
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DNA/RNA Synthesis 抑制剂

Clofarabine具有抗肿瘤活性的第二代嘌呤核苷类似物。了解更多

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- Xie J, .et al. Optimization of a clofarabine-based drug combination regimen for the preclinical evaluation of pediatric acute lymphoblastic leukemia, Pediatr Blood Cancer, 2019, Dec 25:e28133 PMID: 31876116
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Cryptotanshinone

Catalog No. A10244
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Stat3 抑制剂

Cryptotanshinone是一种STAT3抑制剂，在DU145细胞中能显着阻断STAT3 Tyr705磷酸化，但不能阻断STAT3 Ser727磷酸化，并显着抑制JAK2磷酸化，IC50为?5μM，而不影响上游激酶c的磷酸化。了解更多

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CYC116 (CYC-116)

Catalog No. A10248
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Aurora Kinase 抑制剂

CYC116 (CYC-116)是一种有效的Aurora A/B抑制剂，Ki为8.0 nM/9.2 nM，对VEGFR2(Ki为44 nM)作用稍弱。了解更多

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Dutasteride (Avodart)

Catalog No. A10338
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dual 5alpha-reductase 抑制剂

Dutasteride (Avodart)是双重的5-a还原酶抑制剂，可抑制睾丸激素转化为二氢睾丸激素（DHT）。了解更多

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- Makoto Ishikawa, .et al. Additive neuroprotective effects of 24(S)-hydroxycholesterol and allopregnanolone in an ex vivo rat glaucoma model, Sci Rep, 2018, 8: 12851 PMID: 30150786
- Makoto Ishikawa, .et al. TSPO activation modulates the effects of high pressure in a rat ex vivo glaucoma model, Neuropharmacology, 2016, Dec; 111: 142-159 PMID: 27596950
- Makoto Ishikawa, .et al. Neurosteroids Are Endogenous Neuroprotectants in an Ex Vivo Glaucoma Model, Invest Ophthalmol Vis Sci., 2014, 55(12): 8531-8541 PMID: 25406290
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E7080 (Lenvatinib)

Catalog No. A10340
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VEGFR 抑制剂

E7080 (Lenvatinib)是一种多激酶抑制剂，可同时抑制VEGFR2和VEGFR3激酶。了解更多

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- Mai Nakahara, .et al. Effect of Lenvatinib treatment on the cell cycle and microRNA profile in hepatocellular carcinoma cells, Biomed Rep, 2022, Aug 3;17(4):78 PMID: 36158319
- Paula Sagmeister, .et al. Comparative Response of HCC Cells to TKIs: Modified in vitro Testing and Descriptive Expression Analysis, J Hepatocell Carcinoma, 2022, Jul 9;9:595-607 PMID: 35845819
- Aya Hasan Alshammari, .et al. Discrimination of hand-foot skin reaction caused by tyrosine kinase inhibitors based on direct keratinocyte toxicity and vascular endothelial growth factor receptor-2 inhibition, Biochem Pharmacol, 2022, Mar;197:114914 PMID: 35041812
- Keisuke Enomoto, .et al. Synergistic Effects of Lenvatinib (E7080) and MEK Inhibitors against Anaplastic Thyroid Cancer in Preclinical Models, Cancers (Basel), 2021, Feb 18;13(4):862 PMID: 33670725
- Jindal A, .et al. Milciclib and sorafenib synergistically downregulate c-Myc to suppress tumor growth in an orthotopic murine model of human hepatocellular carcinoma, J Transl Sci, 2020, 7: 1-10
- Koide H, .et al. Substrate-dependent effects of molecular-targeted anticancer agents on activity of organic anion transporting polypeptide 1B1, Xenobiotica, 2018, Oct;48(10):1059-1071 PMID: 29034773
- Fujita KI, .et al. Involvement of the Transporters P-Glycoprotein and Breast Cancer Resistance Protein in Dermal Distribution of the Multikinase Inhibitor Regorafenib and Its Active Metabolites, J Pharm Sci, 2017, Sep;106(9):2632-2641 PMID: 28479358
- Tomoko Ogawa-Morita, .et al. Validation of a Liquid Chromatography-Tandem Mass Spectrometric Assay for Quantitative Analysis of Lenvatinib in Human Plasma, Int J Anal Chem, 2017, 2017: 2341876 PMID: 28680445
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Epirubicin HCl

Catalog No. A10345
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Topoisomerase II 抑制剂

Epirubicin HCl是一种可透过细胞的蒽环类抗肿瘤抗生素。它用于抑制拓扑异构酶II和DNA解旋酶活性。了解更多

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Oxaliplatin (Eloxatin)

Catalog No. A10346
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DNA/RNA Synthesis 抑制剂

Oxaliplatin (Eloxatin)是一种DNA/RNA Synthesis抑制剂，具有抗结肠癌的抗肿瘤活性。了解更多

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- Mohamed Elbadawy, .et al. Anti-cancer activity of amorphous curcumin preparation in patient-derived colorectal cancer organoids, Biomed Pharmacother, 2021, Oct;142:112043 PMID: 34411919
- Tatsuya Usui, .et al. Hedgehog Signals Mediate Anti-Cancer Drug Resistance in Three-Dimensional Primary Colorectal Cancer Organoid Culture, Int J Mol Sci, 2018, Apr; 19(4): 1098 PMID: 29642386
- Shimokawa M, .et al. Visualization and targeting of LGR5+ human colon cancer stem cells, Nature, 2017, May 11;545(7653):187-192 PMID: 28355176
- Eri Takiguchi, .et al. Growth inhibitory effect of the Src inhibitor dasatinib in combination with anticancer agents on uterine cervical adenocarcinoma cells, Exp Ther Med, 2017, Nov; 14(5): 4293-4299 PMID: 29067110
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Elvitegravir (GS-9137)

Catalog No. A10347
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HIV integrase 抑制剂

Elvitegravir (GS-9137)是一种有效的抑制剂，可抑制人类1型免疫缺陷病毒（HIV-1）整合酶介导的整合链转移步骤。了解更多

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- Lea El Khoury, .et al. Spectrometric and computational studies of the binding of HIV-1 integrase inhibitors to viral DNA extremities, PeerJ Preprints, 2019, 7:e27833v1
- El Khoury L, .et al. The inhibition process of HIV-1 integrase by diketoacids molecules: Understanding the factors governing the better efficiency of dolutegravir, Biochem Biophys Res Commun, 2017, Jul 1;488(3):433-438 PMID: 28478035
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Etoposide (VP-16)

Catalog No. A10373
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Topoisomerase II 抑制剂

Etoposide (VP-16)是通过抑制topoisomerase II活性而抑制DNA合成。了解更多

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- Reiko Watanabe, .et al. Development of an In Silico Prediction Model for P-glycoprotein Efflux Potential in Brain Capillary Endothelial Cells toward the Prediction of Brain Penetration, J Med Chem, 2021, Mar 11;64(5):2725-2738 PMID: 33619967
- Chen JC, .et al. In Vitro and In Silico Mechanistic Insights into miR-21-5p-Mediated Topoisomerase Drug Resistance in Human Colorectal Cancer Cells, Biomolecules, 2019, Sep 9;9(9) PMID: 31505885
- Takashi Azuma, .et al. Removal of pharmaceuticals in water by introduction of ozonated microbubbles, SEP PURIF TECHNOL, 2019, Apr; 212: 483-489
- Calhelha RC, .et al. Mathematical models of cytotoxic effects in endpoint tumor cell line assays: critical assessment of the application of a single parametric value as a standard criterion to quantify the dose-response effects and new unexplored proposal formats, Analyst, 2017, Oct 23;142(21):4124-4141 PMID: 28991301
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EX 527 (Selisistat)

Catalog No. A10377
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SIRT1 抑制剂

EX 527 (Selisistat)是一种有效的选择性SIRT1 III类组蛋白脱乙酰基酶抑制剂，在无细胞分析中的IC50为38 nM。了解更多

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- Takeshi Nakamura, .et al. Effects of NAD+ Synthesis Levels on Sirtuin 1 Deacetylase Activity in Mammalian Cells, Shimane Journal of Medical Science, 2022, 38 (2), 59-66
- Bugga Paramesha, .et al. Sirt1 and Sirt3 Activation Improved Cardiac Function of Diabetic Rats via Modulation of Mitochondrial Function, Antioxidants (Basel), 2021, Feb 24;10(3):338 PMID: 33668369
- Wenhui Yao, .et al. Icariin ameliorates endothelial dysfunction in type 1 diabetic rats by suppressing ER stress via the PPARα/Sirt1/AMPKα pathway, J Cell Physiol, 2020, 07 August
- Guang Bai, .et al. Chapter 1 - Epigenetic Tools in Chronic Pain Studies, Epigenetics of Chronic Pain, 2019, Pages 1-48
- Yoshikawa A, .et al. Deletion of Atf6α impairs astroglial activation and enhances neuronal death following brain ischemia in mice, J Neurochem, 2015, Feb;132(3):342-53 PMID: 25351847
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Exemestane

Catalog No. A10378
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Aromatase 抑制剂

Exemestane是一种口服类固醇芳香化酶抑制剂，除绝经后妇女的手术和/或放疗外，还用于ER阳性乳腺癌。了解更多

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FK-506 (Tacrolimus)

Catalog No. A10389
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mTOR 抑制剂

FK-506 (Tacrolimus)是一种免疫抑制药物，通过结合到抑免蛋白FKBP12 (FK506 结合蛋白)产生新的复合物，从而降低T细胞中肽酰脯氨酰异构酶活性。了解更多

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- Ogawa Y, .et al. Inhibition of astrocytic adenosine receptor A2A attenuates microglial activation in a mouse model of Sandhoff disease, Neurobiol Dis, 2018, Oct;118:142-154 PMID: 30026035
- Yuko Okamoto, .et al. In vivo drug delivery efficiency of albumin-encapsulated liposomes as hydrophobic drug carriers, J Drug Deliv Sci Technol, 2018, 47: 62-66
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Fludarabine (Fludara)

Catalog No. A10396
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STAT 抑制剂

Fludarabine或fludarabine(fludara)是一种用于治疗血液恶性肿瘤(血细胞癌，如白血病和淋巴瘤)的化疗药物。Fludarabine通过干扰核糖核苷酸还原酶和DNA聚合酶来抑制DNA合成。它对分裂细胞和静止细胞都有活性。了解更多

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- Irene Dell'Anno, .et al. Drug-repositioning screening identified fludarabine and risedronic acid as potential therapeutic compounds for malignant pleural mesothelioma, Invest New Drugs, 2020, Dec 9 PMID: 33300108
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Galanthamine hydrobromide

Catalog No. A10416
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AChE 抑制剂

Galanthamine hydrobromide是一种乙酰胆碱酯酶抑制剂，IC50为14 nM。了解更多

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Gossypol

Catalog No. A10435
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dehydrogenase inhibitor

Gossypol是一种多酚醛，渗透细胞并作为几种脱氢酶的抑制剂。了解更多

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- Amy L. Farthing, .et al. Response of northern bobwhites fed single doses of gossypol, Wildlife Society Bulletin, 2018, 42(3):460-466;
- Jin Qu, .et al. Gossypol potentiates carboplatin effects against ovarian cancer, Biomed Res, 2017, 28 (8): 3355-3361
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GSK429286A

Catalog No. A10441
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ROCK 抑制剂

GSK429286A是含有蛋白激酶(ROCK)的Rho相关卷曲螺旋的细胞渗透性选择性小分子抑制剂。了解更多

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Hesperetin

Catalog No. A10449
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PDE4 抑制剂

Hesperetin是一种选择性磷酸二酯酶(PDE)4抑制剂，存在于中药“陈皮”中。橙皮素是一种柑橘类黄酮，据报道可以降低血浆胆固醇。橙皮素降低Hep-G2细胞中ACAT-2 mRNA的转录，并以剂量依赖的方式降低ApoB蛋白的合成。它也是类癌的潜在疗法。了解更多

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Irinotecan

Catalog No. A10478
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Topoisomerase I 抑制剂

Irinotecan通过抑制拓扑异构酶防止DNA解链。了解更多

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- Gils Jose, .et al. Co-Delivery of CPT-11 and Panobinostat with Anti-GD2 Antibody Conjugated Immunoliposomes for Targeted Combination Chemotherapy, Cancers (Basel), 2020, Oct 31;12(11):E3211 PMID: 33142721
- T Kannathasan, .et al. Chemoresistance-Associated Silencing of miR-4454 Promotes Colorectal Cancer Aggression through the GNL3L and NF-κB Pathway, Cancers (Basel), 2020, May; 12(5): 1231 PMID: 32422901
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Ki8751

Catalog No. A10502
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VEGFR-2 抑制剂

ki8751是一种细胞可渗透的喹啉氧基苯基脲化合物，在基于细胞和无细胞的检测中起Flk-1 (VEGFR-2)选择性抑制剂的作用。了解更多

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- Kohei Ashina, .et al. VEGF-induced blood flow increase causes vascular hyper-permeability in vivo, Biochem Biophys Res Commun, 2015, Aug 21;464(2):590-5 PMID: 26163262
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KU-60019

Catalog No. A10507
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ATM 抑制剂

KU-60019是一种强效特异性ATM抑制剂，IC50为6.3 nM。了解更多

Product Citations (4)

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- Fu-Xing Gong, .et al. De-dimerization of PTB is catalyzed by PDI and is involved in the regulation of p53 translation, Nucleic Acids Res, 2021, Sep 20;49(16):9342-9352 PMID: 34403458
- Hegedus C, .et al. PARP1 Inhibition Augments UVB-Mediated Mitochondrial Changes-Implications for UV-Induced DNA Repair and Photocarcinogenesis, Cancers (Basel), 2019, Dec 18;12(1) PMID: 31861350
- Masaya Igase, .et al. Combination Therapy with Reovirus and ATM Inhibitor Enhances Cell Death and Virus Replication in Canine Melanoma, Mol Ther Oncolytics, 2019, vol 15 PMID: 31650025
- CHENGHUA LOU, .et al. Targeting the ataxia telangiectasia mutated pathway for effective therapy against hirsutine-resistant breast cancer cells, Oncol Lett, 2016, Jul; 12(1): 295-300 PMID: 27347141
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LAQ824 (NVP-LAQ824, Dacinostat)

Catalog No. A10516
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HDAC 抑制剂

LAQ824 (NVP-LAQ824)是一种有效的新型组蛋白去乙酰化酶抑制剂，具有显著的抗多发性骨髓瘤活性。了解更多

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- De-Run Chen, .et al. Engineered nanogels simultaneously implement HDAC inhibition and chemotherapy to boost antitumor immunity via pyroptosis, Appl Mater Today, 2022, 26: 101363
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Letrozole

Catalog No. A10523
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Aromatase 抑制剂

Letrozole是芳香酶抑制剂。CGS 20267是一种新型的非甾体化合物，在体外（IC50为11.5 nM）和在体内（ED50为1-3μg/ kg p.o.）均能有效抑制芳香化酶。了解更多

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- WEI LIU, .et al. Randomized controlled trial comparing letrozole with laparoscopic ovarian drilling in women with clomiphene citrate-resistant polycystic ovary syndrome, Exp Ther Med, 2015, Oct; 10(4): 1297-1302 PMID: 26622481
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Linezolid (PNU-100766)

Catalog No. A10533
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Protein synthesis 抑制剂

Linezolid是一种用于治疗严重感染的合成抗生素。了解更多

Product Citations (3)

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- Viktoria Lazar, .et al. Antibiotic combinations reduce Staphylococcus aureus clearance, Nature, 2022, 610: 540-546 PMID: 36198788
- Zewen Wen, .et al. In vitro activity and adaptation strategies of eravacycline in clinical Enterococcus faecium isolates from China, J Antibiot (Tokyo), 2022, Sep;75(9):498-508 PMID: 35896611
- Meikle V, .et al. A protein complex from human milk enhances the activity of antibiotics and drugs against Mycobacterium tuberculosis, Antimicrob Agents Chemother, 2018, Nov 12. pii: AAC.01846-18 PMID: 30420480
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Lopinavir (ABT-378)

Catalog No. A10537
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HIV Protease 抑制剂

Lopinavir (ABT-378)是HIV蛋白酶的抑制剂。了解更多

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Luteolin

Catalog No. A10541
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PDE4 抑制剂

Luteolin是PDE4抑制剂、磷酸二酯酶抑制剂和白细胞介素6抑制剂，影响木聚嗪/氯胺酮诱导的小鼠麻醉。Luteolin作为单胺转运蛋白激活剂，是少数证明具有这种性质的化学物质之一。了解更多

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LX 1606 Hippurate

Catalog No. A10542
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Hydroxylase 抑制剂

LX 1606 hippurate是一种口服生物可利用的小分子色氨酸羟化酶(TPH)抑制剂，具有潜在的抗旋转能活性。了解更多

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Rifabutin

Catalog No. A10790
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RNA polymerase 抑制剂

Rifabutin是一种主要用于治疗肺结核的杀菌抗生素。它的作用是基于阻断细菌的DNA依赖性RNA聚合酶。了解更多

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- Matt D Johansen, .et al. Rifabutin is bactericidal against intracellular and extracellular forms of Mycobacterium abscessus, Antimicrob Agents Chemother, 2020, Aug 17;AAC.00363-20 PMID: 32816730
- Meikle V, .et al. A protein complex from human milk enhances the activity of antibiotics and drugs against Mycobacterium tuberculosis, Antimicrob Agents Chemother, 2018, Nov 12. pii: AAC.01846-18 PMID: 30420480
- Dinah Binte Aziz, .et al. Rifabutin Is Active against Mycobacterium abscessus Complex, Antimicrob Agents Chemother, 2017, Jun; 61(6): e00155-17 PMID: 28396540
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Bosentan

Catalog No. A11091
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ETAR/ETBR 抑制剂

Bosentan是内皮素-1（ET-A）和内皮素B（ET-B）受体的竞争性拮抗剂。了解更多

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Linagliptin (BI-1356)

Catalog No. A11224
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DPP-4 抑制剂

Linagliptin (BI-1356)是DPP-4抑制剂，是一种降解肠降血糖素激素胰高血糖素样肽1（GLP-1）和葡萄糖依赖性促胰岛素多肽（GIP）的酶。了解更多

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Aliskiren (CGP 60536)

Catalog No. A11616
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Renin 抑制剂

Aliskiren (CGP 60536)是一种合成非肽肾素抑制剂。了解更多

Product Citations (1)

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- Karibe T, .et al. Curcumin as an In Vivo Selective Intestinal Breast Cancer Resistance Protein Inhibitor in Cynomolgus Monkeys, Drug Metab Dispos, 2018, May;46(5):667-679 PMID: 29358184
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EMD-1214063

Catalog No. A11257
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c-Met 抑制剂

EMD-1214063是MET酪氨酸激酶的抑制剂，IC50为4 nM，作用于c-Met比作用于IRAK4， TrkA， Axl， IRAK1和Mer选择性高200倍以上。具有潜在的抗肿瘤活性。它与MET酪氨酸激酶结合并破坏MET信号转导途径，这可能在过表达该激酶的肿瘤细胞中诱导凋亡。了解更多

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MLN4924 (Pevonedistat)

Catalog No. A11260
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NAE 抑制剂

MLN4924 (Pevonedistat)是NAE的小分子抑制剂，是导致肿瘤细胞增殖和存活的抑制剂。了解更多

Product Citations (6)

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- Corentin Mallet, .et al. Hypoxia and HIF-1 Trigger Marek's Disease Virus Reactivation in Lymphoma-Derived Latently Infected T Lymphocytes, J Virol, 2021, Dec 22;JVI0142721 PMID: 34936483
- Nobuyuki Shimizu, .et al. PLZF and its fusion proteins are pomalidomide-dependent CRBN neosubstrates, Commun Biol, 2021, Nov 11;4(1):1277 PMID: 34764413
- Jalila Chagraoui, .et al. UM171 Preserves Epigenetic Marks that Are Reduced in Ex Vivo Culture of Human HSCs via Potentiation of the CLR3-KBTBD4 Complex, Cell Stem Cell, 2021, Jan 7;28(1):48-62.e6 PMID: 33417871
- Stephan Riesenberg, .et al. Targeting repair pathways with small molecules increases precise genome editing in pluripotent stem cells, Nat Commun, 2018, 9: 2164 PMID: 29867139
- Hirosumi Tamura, .et al. Evaluation of anticancer agents using patient-derived tumor organoids characteristically similar to source tissues, Oncol Rep, 2018, Aug; 40(2): 635-646 PMID: 29917168
- Richard J. Kraus, .et al. Hypoxia-inducible factor-1α plays roles in Epstein-Barr virus??s natural life cycle and tumorigenesis by inducing lytic infection through direct binding to the immediate-early BZLF1 gene promoter, PLoS Pathog, 2017, Jun; 13(6): e1006404 PMID: 28617871

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