你的浏览器似乎禁用了 JavaScript。
您必须在浏览器中启用JavaScript才能使用本网站的功能。

微信关注
申请试用装

主页 /
Products On Sale

Products On Sale

Quick View
CP-690550 (Tofacitinib citrate)

Catalog No. A10241
Quick View

添加到收藏
JAK3 抑制剂

CP-690550 (Tofacitinib citrate)是口服的高选择性Janus激酶（JAK）酶抑制剂。了解更多

Product Citations (1)

Bulk Inquiry Free Sample
- Fujita KI, .et al. Involvement of the Transporters P-Glycoprotein and Breast Cancer Resistance Protein in Dermal Distribution of the Multikinase Inhibitor Regorafenib and Its Active Metabolites, J Pharm Sci, 2017, Sep;106(9):2632-2641 PMID: 28479358
Quick View
Daptomycin

Catalog No. A10289
Quick View

添加到收藏
DNA/RNA Synthesis 抑制剂

Daptomycin是一种脂肽抗生素，用于治疗由革兰氏阳性生物体引起的某些感染。了解更多

Product Citations (2)

Bulk Inquiry Free Sample
- Viktoria Lazar, .et al. Antibiotic combinations reduce Staphylococcus aureus clearance, Nature, 2022, 610: 540-546 PMID: 36198788
- Shigeru Fujimura, .et al. Antimicrobial efficacy of combined clarithromycin plus daptomycin against biofilms-formed methicillin-resistant Staphylococcus aureus on titanium medical devices., J Infect Chemother., 2015, Oct;21(10):756-9 PMID: 26162777
Quick View
SNS-032 (BMS-387032)

Catalog No. A10850
Quick View

添加到收藏
CDK 抑制剂

SNS-032（BMS-387032）是细胞周期蛋白依赖性激酶（Cdks）2、7和9的高度选择性和有效抑制剂，具有体外生长抑制作用，并具有诱导恶性B细胞凋亡的能力。了解更多

Bulk Inquiry Free Sample
Quick View
Danoprevir (RG7227)

Catalog No. A10284
Quick View

添加到收藏
HCV NS3/4A protease 抑制剂

Danoprevir (RG7227)是HCV NS3/4A丝氨酸蛋白酶的有效抑制剂。了解更多

Product Citations (3)

Bulk Inquiry Free Sample
- Mahim Khan, .et al. Hesperidin identified from Citrus extracts potently inhibits HCV genotype 3a NS3 protease, BMC Complement Med Ther, 2022, Apr 2;22(1):98 PMID: 35366855
- Inês GARCEZ PALHA, .et al. An in vivo translation-reporter system for the study of protein synthesis in zebrafish embryos, Biol Open, 2018, Nov 7 PMID: 30404898
- Hui Shen, .et al. Inhibitory Effects of Caffeic Acid Phenethyl Ester Derivatives on Replication of Hepatitis C Virus, PLoS One., 2013, 8(12): e82299 PMID: 24358168
Quick View
TAE684

Catalog No. A10662
Quick View

添加到收藏
ALK 抑制剂

TAE684是ALK的抑制剂，也是LRRK2激酶活性的有效抑制剂（针对野生型LRRK2的IC（50）为7.8nM，针对G2019S突变体的为6.1nM）。了解更多

Product Citations (2)

Bulk Inquiry Free Sample
- Li Li, .et al. Evidence for activated Lck protein tyrosine kinase as the driver of proliferation in acute myeloid leukemia cell, CTV-1, Leukemia Res, 2019, 78:12-20 PMID: 30660961
- Li T, .et al. Bruton's tyrosine kinase potentiates ALK signaling and serves as a potential therapeutic target of neuroblastoma, Oncogene, 2018, Nov;37(47):6180-6194 PMID: 30013190
Quick View
PCI-24781 (Abexinostat)

Catalog No. A10700
Quick View

添加到收藏
HDAC 抑制剂

PCI-24781 (Abexinostat)是一种广谱苯基异羟肟酸HDAC抑制剂。了解更多

Bulk Inquiry Free Sample
Quick View
Brivanib (BMS-540215)

Catalog No. A10254
Quick View

添加到收藏
VEGFR-2 抑制剂

Brivanib (BMS-540215)是一种VEGFR-2抑制剂，IC50为25 nM，Ki为26 nM。了解更多

Product Citations (1)

Bulk Inquiry Free Sample
- Hirosumi Tamura, .et al. Evaluation of anticancer agents using patient-derived tumor organoids characteristically similar to source tissues, Oncol Rep, 2018, Aug; 40(2): 635-646 PMID: 29917168
Quick View
Fulvestrant (Faslodex)

Catalog No. A10410
Quick View

添加到收藏
Aromatase 抑制剂

Fulvestrant是一种雌激素受体拮抗剂，没有激动剂作用，它通过下调和降解雌激素受体发挥作用。了解更多

Product Citations (5)

Bulk Inquiry Free Sample
- Samy A. F. Morad, .et al. Role of P-glycoprotein inhibitors in ceramide-based therapeutics for treatment of cancer, Biochem Pharmacol, 2017, Apr 15; 130: 21-33 PMID: 28189725
- Kaneyasu Nishimura, .et al. Estradiol Facilitates Functional Integration of iPSC-Derived Dopaminergic Neurons into Striatal Neuronal Circuits via Activation of Integrin α5β1, Stem Cell Reports, 2016, Apr 12; 6(4): 511-524 PMID: 26997644
- Alejandro S. Cazzulino, .et al. Improved specificity of hippocampal memory trace labeling, Hippocampus, 2016, Jun; 26(6): 752-762 PMID: 26662713
- Rie Mukai, .et al. 8-Prenylnaringenin promotes recovery from immobilization-induced disuse muscle atrophy through activation of the Akt phosphorylation pathway in mice, Am J Physiol Regul Integr Comp Physiol, 2016, Dec 1;311(6):R1022-R1031 PMID: 27629889
- Sakanashi M, .et al. Long-term treatment with san'o-shashin-to, a kampo medicine, markedly ameliorates cardiac ischemia-reperfusion injury in ovariectomized rats via the redox-dependent mechanism., Circ J. , 2013, 77(7):1827-37. PMID: 23615023
Quick View
Doramapimod (BIRB-796)

Catalog No. A10148
Quick View

添加到收藏
p38 MAPK 抑制剂

Doramapimod（BIRB 796）是p38 MAPK的小分子抑制剂，在调节促炎细胞因子的产生中起关键作用。了解更多

Product Citations (3)

Bulk Inquiry Free Sample
- Ken Kobayashi, .et al. Lactose on the basolateral side of mammary epithelial cells inhibits milk production concomitantly with signal transducer and activator of transcription 5 inactivation, Cell Tissue Res, 2022, Sep;389(3):501-515 PMID: 35748981
- Junsuke Uwada, .et al. PNU-120596, a positive allosteric modulator of α7 nicotinic acetylcholine receptor, directly inhibits p38 MAPK, Biochem Pharmacol, 2020, Oct 22;182:114297 PMID: 33132165
- Perera LMB, .et al. The regulation of skin fibrosis in systemic sclerosis by extracellular ATP via P2Y2 purinergic receptor, J Invest Dermatol, 2018, Nov 4. pii: S0022-202X(18)32791-X PMID: 30404019
Quick View
XL765

Catalog No. A10997
Quick View

添加到收藏
PI3K 抑制剂

XL765是PI3K/mTOR双激酶抑制剂，与单独抑制PI3K激酶或mTOR激酶的药物相比，它的效力更高。了解更多

Bulk Inquiry Free Sample
Quick View
Bleomycin sulfate

Catalog No. A10152
Quick View

添加到收藏
DNA/RNA Synthesis 抑制剂

Bleomycin Sulfate硫酸博来霉素是一种糖肽类抗生素，也是一种鳞状细胞癌(SCC)抗癌剂。了解更多

Product Citations (1)

Bulk Inquiry Free Sample
- Mai Kanemaru, .et al. Nanoparticle-mediated local delivery of pioglitazone attenuates bleomycin-induced skin fibrosis, J Dermatol Sci, 2018, Jan;93(1):41-49 PMID: 30655107
Quick View
Tubastatin A HCl

Catalog No. A11042
Quick View

添加到收藏
HDAC6 抑制剂

Tubastatin A HCl是一种有效的选择性HDAC6抑制剂，在无细胞试验中IC50为15 nM。它对除HDAC8（57倍）以外的所有其他同工酶（1000倍）具有选择性。了解更多

Product Citations (2)

Bulk Inquiry Free Sample
- Isin Cakir, .et al. Histone deacetylase 6 inhibition restores leptin sensitivity and reduces obesity, Nat Metab, 2022, Jan;4(1):44-59 PMID: 35039672
- Isin Cakir, .et al. Sulforaphane reduces obesity by reversing leptin resistance, Elife, 2022, Mar 24 PMID: 35323110
Quick View
Bosutinib (SKI-606)

Catalog No. A10161
Quick View

添加到收藏
Src 抑制剂

Bosutinib (SKI-606)是一种酪氨酸激酶抑制剂。了解更多

Product Citations (1)

Bulk Inquiry Free Sample
- Li Li, .et al. Evidence for activated Lck protein tyrosine kinase as the driver of proliferation in acute myeloid leukemia cell, CTV-1, Leukemia Res, 2019, 78:12-20 PMID: 30660961
Quick View
MG-132

Catalog No. A11043
Quick View

添加到收藏
Proteasome 抑制剂

MG-132是蛋白酶体（IC50 = 100 nM）和钙蛋白酶（IC50 = 1.2μM）的有效的细胞渗透抑制剂。了解更多

Product Citations (11)

Bulk Inquiry Free Sample
- Vo Thi Anh Nguyet, .et al. Acquired resistance to severe ethanol stress-induced inhibition of proteasomal proteolysis in Saccharomyces cerevisiae, Biochim Biophys Acta Gen Subj, 2022, Sep 6;1866(12):130241 PMID: 36075516
- Jalila Chagraoui, .et al. UM171 Preserves Epigenetic Marks that Are Reduced in Ex Vivo Culture of Human HSCs via Potentiation of the CLR3-KBTBD4 Complex, Cell Stem Cell, 2021, Jan 7;28(1):48-62.e6 PMID: 33417871
- Eunsu Yoo, .et al. Anti-proliferative activity of A. Oxyphylla and its bioactive constituent nootkatone in colorectal cancer cells, BMC Cancer, 2020, Sep 14;20(1):881 PMID: 32928152
- Hua Xu, .et al. Preclinical Study Using ABT263 to Increase Enzalutamide Sensitivity to Suppress Prostate Cancer Progression Via Targeting BCL2/ROS/USP26 Axis Through Altering ARv7 Protein Degradation, Cancers (Basel), 2020, Apr; 12(4): 831 PMID: 32235588
- Chi-Hung R Or, .et al. Obatoclax, a Pan-BCL-2 Inhibitor, Downregulates Survivin to Induce Apoptosis in Human Colorectal Carcinoma Cells Via Suppressing WNT/β-catenin Signaling, Int J Mol Sci, 2020, Mar 5;21(5):1773 PMID: 32150830
- Ghosh S, .et al. Interactions between Viperin, Vesicle-Associated Membrane Protein A, and Hepatitis C Virus Protein NS5A Modulate Viperin Activity and NS5A Degradation, Biochemistry, 2020, Feb 18;59(6):780-789 PMID: 31977203
- Kondo H, .et al. PITHD1 is a proteasome-interacting protein essential for male fertilization, J Biol Chem, 2020, Feb 7;295(6):1658-1672 PMID: 31915251
- Ohigashi I, .et al. Trans-omics Impact of Thymoproteasome in Cortical Thymic Epithelial Cells, Cell Rep, 2019, Nov 26;29(9):2901-2916 PMID: 31775054
- Paudel DB, .et al. Expression and antiviral function of ARGONAUTE 2 in Nicotiana benthamiana plants infected with two isolates of tomato ringspot virus with varying degrees of virulence, Virology, 2018, Nov;524:127-139 PMID: 30195250
- Ohkusu-Tsukada K, .et al. The Role of Proteasome Inhibitor MG132 in 2,4-Dinitrofluorobenzene-Induced Atopic Dermatitis in NC/Nga Mice, Int Arch Allergy Immunol, 2018, 176(2):91-100 PMID: 29669333
- Chi-Hung R. Or, .et al. Obatoclax, a Pan-BCL-2 Inhibitor, Targets Cyclin D1 for Degradation to Induce Antiproliferation in Human Colorectal Carcinoma Cells, Int J Mol Sci, 2016, Jan; 18(1): 44 PMID: 28035994
Quick View
Fluorouracil (Adrucil)

Catalog No. A10042
Quick View

添加到收藏
DNA and RNA synthesis 抑制剂

Fluorouracil (Adrucil)是一种是DNA/RNA合成抑制剂，通过不可逆地抑制胸苷酸合酶起作用。了解更多

Product Citations (1)

Bulk Inquiry Free Sample
- T Hoshiba ,etc. Decellularized matrices as in vitro models of extracellular matrix in tumor tissues at different malignant levels: Mechanism of 5-fluorouracil resistance in colorectal tumor cells. Biochimica et Biophysica Acta (BBA)-Molecular Cell Research, 2016, 1863(11), 2749-2757.
Quick View
Gemcitabine HCl (Gemzar)

Catalog No. A10423
Quick View

添加到收藏
DNA/RNA Synthesis 抑制剂

Gemcitabine HCl (Gemzar)是一种DNA synthesis抑制剂，作用于PANC1，MIAPaCa2，BxPC3和Capan2细胞，通过在癌细胞dna复制过程中取代核酸的一个组成部分，防止肿瘤生长。了解更多

Product Citations (1)

Bulk Inquiry Free Sample
- G. R. Iglesias, .et al. Hyperthermia-Triggered Gemcitabine Release from Polymer-Coated Magnetite Nanoparticles, Polymers, 2018, 10(3), 269
Quick View
PHA-793887

Catalog No. A10716
Quick View

添加到收藏
CDK 抑制剂

PHA-793887是一种新型有效的CDK2，CDK5和CDK7抑制剂，IC50分别为8 nM，5 nM 和10 nM，作用于CDK2，5，和7比作用于CDK1，4，和9选择性高6倍以上。可在低浓度下靶向多种细胞周期蛋白依赖性激酶，并具有针对多种癌细胞的高活性。了解更多

Product Citations (1)

Bulk Inquiry Free Sample
- Hirosumi Tamura, .et al. Evaluation of anticancer agents using patient-derived tumor organoids characteristically similar to source tissues, Oncol Rep, 2018, Aug; 40(2): 635-646 PMID: 29917168
Quick View
AT7519

Catalog No. A10093
Quick View

添加到收藏
CDK 抑制剂

AT7519是多种细胞周期蛋白依赖性激酶（CDK）的抑制剂，可导致细胞周期停滞，诱导细胞凋亡和抑制肿瘤细胞增殖。作用于CDK1，2，4，6和9时，IC50为10-210 nM，对CDK3作用效果稍弱，对CDK7几乎没有抑制活性。了解更多

Bulk Inquiry Free Sample
Quick View
BS-181

Catalog No. A10163
Quick View

添加到收藏
CDK 抑制剂

BS-181 是作为CDK7抑制剂的潜在抗肿瘤剂。了解更多

Bulk Inquiry Free Sample
Quick View
Flavopiridol HCl

Catalog No. A11045
Quick View

添加到收藏
CDK 抑制剂

Flavopiridol HCl是细胞周期蛋白依赖性激酶的抑制剂。（-）-顺式形式诱导特定肿瘤细胞的凋亡。了解更多

Bulk Inquiry Free Sample
Quick View
CHIR-124

Catalog No. A11046
Quick View

添加到收藏
CHK 抑制剂

CHIR-124是一种新型有效的Chk1抑制剂（Chk1和Chk2的IC50：分别为0.32 nM和697 nM）。了解更多

Bulk Inquiry Free Sample
Quick View
Chrysophanic acid (Chrysophanol)

Catalog No. A10210
Quick View

添加到收藏
EGFR 抑制剂

Chrysophanic acid (Chrysophanol)是通过抑制EGFR/mTOR通路来阻止结肠癌细胞的增殖。了解更多

Bulk Inquiry Free Sample
Quick View
Icariin

Catalog No. A10464
Quick View

添加到收藏
PDE5 抑制剂

Icariin对抑制PDE5A1、PDE5A2和PDE5A3的所有三种PDE5A亚型均有抑制作用，IC50值分别为1.0、0.75和1.1 μM。了解更多

Bulk Inquiry Free Sample
Quick View
OSU-03012

Catalog No. A10681
Quick View

添加到收藏
PDK-1 抑制剂

OSU-03012 (AR-12)是一种有效的重组PDK-1(phosphoinositide-dependent kinase 1)抑制剂。了解更多

Bulk Inquiry Free Sample
Quick View
URB597

Catalog No. A11049
Quick View

添加到收藏
FAAH 抑制剂

URB597是脂肪酸酰胺水解酶（FAAH）的相对选择性抑制剂。了解更多

Product Citations (3)

Bulk Inquiry Free Sample
- Lakhan S Khara, .et al. Inhibiting the endocannabinoid degrading enzymes FAAH and MAGL during zebrafish embryogenesis alters sensorimotor function, J Exp Biol, 2022, May 1;225(9):jeb244146 PMID: 35438163
- Md Shah Sufian, .et al. Early suppression of the endocannabinoid degrading enzymes FAAH and MAGL alters locomotor development in zebrafish, J Exp Biol, 2021, 21 JUNE
- Toshihiko Tsutsumi, .et al. Identification of human glycerophosphodiesterase 3 as an ecto phospholipase C that converts the G protein-coupled receptor 55 agonist lysophosphatidylinositol to bioactive monoacylglycerols in cultured mammalian cells, Biochim Biophys Acta Mol Cell Biol Lipids, 2020, Sep;1865(9):158761 PMID: 32629025
Quick View
Decitabine

Catalog No. A10292
Quick View

添加到收藏
DNA Methyltransferase 抑制剂

Decitabine是一种次甲基化剂，它通过抑制DNA甲基转移酶来使DNA次甲基化。了解更多

Product Citations (4)

Bulk Inquiry Free Sample
- Borbala Szabo, .et al. Aspirin mediates its antitumoral effect through inhibiting PTTG1 in pituitary adenoma, J Clin Endocrinol Metab, 2022, Sep 5;dgac496 PMID: 36059148
- Sangni Qian, .et al. Hypermethylation of tumor suppressor lncRNA MEF2C-AS1 frequently happened in patients at all stages of colorectal carcinogenesis, Clin Epigenetics, 2022, Sep 5;14(1):111 PMID: 36064442
- Borb??la Szab??, .et al. Demethylation status of somatic DNA extracted from pituitary neuroendocrine tumors indicates proliferative behavior, J Clin Endocrinol Metab, 2020, Jun 1;105(6):dgaa156 PMID: 32232382
- Bracha Shraibman, .et al. Human Leukocyte Antigen (HLA) Peptides Derived from Tumor Antigens Induced by Inhibition of DNA Methylation for Development of Drug-facilitated Immunotherapy, Mol Cell Proteomics, 2016, Sep; 15(9): 3058-3070 PMID: 27412690
Quick View
SB 202190

Catalog No. A10823
Quick View

添加到收藏
p38 MAPK 抑制剂

SB202190是p38 MAP激酶的高度选择性，有效和细胞渗透性抑制剂。了解更多

Product Citations (4)

Bulk Inquiry Free Sample
- Dan Zhao, .et al. From crypts to enteroids: establishment and characterization of avian intestinal organoids, Poult Sci, 2022, Mar; 101(3): 101642 PMID: 35016046
- Yang PM, .et al. p38α/S1P/SREBP2 activation by the SAM-competitive EZH2 inhibitor GSK343 limits its anticancer activity but creates a druggable vulnerability in hepatocellular carcinoma, Am J Cancer Res, 2019, Oct 1;9(10):2120-2139 PMID: 31720078
- Tsai CC, .et al. Protease-activated receptor 2 induces migration and promotes Slug-mediated epithelial-mesenchymal transition in lung adenocarcinoma cells, Biochim Biophys Acta Mol Cell Res, 2018, Oct 13. pii: S0167-4889(18)30452-X PMID: 30321617
- Jia-Shiuan Tsai, .et al. Cadmium Activates Multiple Signaling Pathways That Coordinately Stimulate Akt Activity to Enhance c-Myc mRNA Stability, PLoS One, 2016, 11(1): e0147011 PMID: 26751215
Quick View
Raltegravir (MK-0518)

Catalog No. A10775
Quick View

添加到收藏
HIV-1 integrase 抑制剂

Raltegravir (MK-0518)靶向整合酶，这是一种HIV酶，可将病毒遗传物质整合到人类染色体中，这是HIV发病机理中的关键步骤。了解更多

Product Citations (2)

Bulk Inquiry Free Sample
- Michal S Barski, .et al. Structural basis for the inhibition of HTLV-1 integration inferred from cryo-EM deltaretroviral intasome structures, Nat Commun, 2021, Aug 17;12(1):4996 PMID: 34404793
- Lea El Khoury, .et al. Spectrometric and computational studies of the binding of HIV-1 integrase inhibitors to viral DNA extremities, PeerJ Preprints, 2019, 7:e27833v1
Quick View
Geldanamycin

Catalog No. A11025
Quick View

添加到收藏
Hsp90 抑制剂

Geldanamycin与Hsp90的ATP位点（Kd = 1.2μM）结合并抑制其分子伴侣活性。了解更多

Product Citations (1)

Bulk Inquiry Free Sample
- Michael Heider, .et al. The IMiD target CRBN determines HSP90 activity toward transmembrane proteins essential in multiple myeloma, Mol Cell, 2021, Mar 18;81(6):1170-1186 PMID: 33571422
Quick View
LY2228820 (Ralimetinib)

Catalog No. A10545
Quick View

添加到收藏
p38 MAPK 抑制剂

LY2228820 (Ralimetinib)是一种新型强效p38MAPK抑制剂，具有强效抗炎活性。了解更多

Bulk Inquiry Free Sample
Quick View
Voriconazole (Vfend)

Catalog No. A10978
Quick View

添加到收藏
CYP17 抑制剂

Voriconazole (Vfend)是一种三唑抗真菌剂，可以冻干粉的形式用于静脉输注溶液。了解更多

Bulk Inquiry Free Sample
Quick View
Bafetinib (INNO-406)

Catalog No. A10119
Quick View

添加到收藏
Bcr-Abl 抑制剂

Bafetinib (INNO-406)是一种双重Bcr-Abl/Lyn酪氨酸激酶抑制剂。了解更多

Product Citations (4)

Bulk Inquiry Free Sample
- Li T, .et al. Bruton's tyrosine kinase potentiates ALK signaling and serves as a potential therapeutic target of neuroblastoma, Oncogene, 2018, Nov;37(47):6180-6194 PMID: 30013190
- S. Dallari, .et al. Src family kinases Fyn and Lyn are constitutively activated and mediate plasmacytoid dendritic cell responses, Nat Commun, 2017, 8: 14830 PMID: 28368000
- Andrea Haerzschel, .et al. BCR and chemokine responses upon anti-IgM and anti-IgD stimulation in chronic lymphocytic leukaemia, Ann Hematol, 2016, 95(12): 1979-1988 PMID: 27542958
- Magdalena Winiarska, .et al. Inhibitors of SRC kinases impair antitumor activity of anti-CD20 monoclonal antibodies, MAbs., 2014, 6(5): 1300-1313. PMID: 25517315
Quick View
Cyt387 (Momelotinib)

Catalog No. A10263
Quick View

添加到收藏
JAK 抑制剂

Cyt387 (Momelotinib)是Janus激酶JAK1和JAK2的抑制剂，可作为ATP竞争者，IC50值分别为11和18 nM。了解更多

Product Citations (1)

Bulk Inquiry Free Sample
- Alex Bainbridge, .et al. IKBKE activity enhances AR levels in advanced prostate cancer via modulation of the Hippo pathway, Nucleic Acids Research, 2020, April
Quick View
Kaempferol

Catalog No. A10495
Quick View

添加到收藏
ERRα and ERRγ inverse 激动剂

Kaempferol被发现抑制Ki为0.3-0.5 μM的牛主动脉肌球蛋白轻链激酶，并且还被发现通过新的ERK-NFκB-cMyc-p21途径抑制VEGF表达和体外血管生成。了解更多

Bulk Inquiry Free Sample
Quick View
PF299804 (Dacomitinib, PF299)

Catalog No. A11051
Quick View

添加到收藏
EGFR 抑制剂

PF299804是一种有效的，可口服的酪氨酸激酶人表皮生长因子受体（HER）1（EGFR），HER2和HER4不可逆抑制剂。了解更多

Product Citations (5)

Bulk Inquiry Free Sample
- Aya Hasan Alshammari, .et al. Discrimination of hand-foot skin reaction caused by tyrosine kinase inhibitors based on direct keratinocyte toxicity and vascular endothelial growth factor receptor-2 inhibition, Biochem Pharmacol, 2022, Mar;197:114914 PMID: 35041812
- Hamzehlou S, .et al. Anti-tumor activity of neratinib, a pan-HER inhibitor, in gastric adenocarcinoma cells, Eur J Pharmacol, 2019, Nov 15;863:172705 PMID: 31574259
- Momeny M, .et al. The ERBB receptor inhibitor dacomitinib suppresses proliferation and invasion of pancreatic ductal adenocarcinoma cells, Cell Oncol (Dordr), 2019, Apr 25 PMID: 31025257
- Majid Momeny, .et al. Dacomitinib, a pan-inhibitor of ErbB receptors, suppresses growth and invasive capacity of chemoresistant ovarian carcinoma cells, Sci Rep, 2017, 7: 4204 PMID: 28646172
- Fujita KI, .et al. Involvement of the Transporters P-Glycoprotein and Breast Cancer Resistance Protein in Dermal Distribution of the Multikinase Inhibitor Regorafenib and Its Active Metabolites, J Pharm Sci, 2017, Sep;106(9):2632-2641 PMID: 28479358
Quick View
Crenolanib (CP-868596)

Catalog No. A11052
Quick View

添加到收藏
PDGFR/FLT3 抑制剂

Crenolanib (CP-868596)是口服生物可用的PDGFR酪氨酸激酶的选择性小分子抑制剂，在皮摩尔浓度下抑制PDGFRA和PDGFRB。了解更多

Product Citations (1)

Bulk Inquiry Free Sample
- N Naganna, .et al. Amino alkynylisoquinoline and alkynylnaphthyridine compounds potently inhibit acute myeloid leukemia proliferation in mice, EBioMedicine, 2019, Jan 24. pii: S2352-3964(19)30012-X PMID: 30686755
Quick View
OSI-906

Catalog No. A11053
Quick View

添加到收藏
IGF-1R 抑制剂

OSI-906是一种选择性IGF-1R抑制剂，在无细胞试验中IC50为35 nM；对InsR抑制作用适中，IC50为75 nM，对Abl，ALK，BTK，EGFR， FGFR1/2，PKA等没有抑制活性。了解更多

Product Citations (4)

Bulk Inquiry Free Sample
- Masao Kakoki, .et al. Cyanocobalamin prevents cardiomyopathy in type 1 diabetes by modulating oxidative stress and DNMT-SOCS1/3-IGF-1 signaling, Communications Biology, 2021, 4:775
- Nakamura T, .et al. Naturally Occurring Hair Growth Peptide: Water-Soluble Chicken Egg Yolk Peptides Stimulate Hair Growth Through Induction of Vascular Endothelial Growth Factor Production, J Med Food, 2018, Jul;21(7):701-708 PMID: 29583066
- Tzeng SF, .et al. O-Glycosylation-mediated signaling circuit drives metastatic castration-resistant prostate cancer, FASEB J, 2018, Jun 15:fj201800687 PMID: 29906246
- Takata N, .et al. IGF-2/IGF-1R signaling has distinct effects on Sox1, Irx3, and Six3 expressions during ES cell derived-neuroectoderm development in vitro, In Vitro Cell Dev Biol Anim., 2016, May;52(5):607-15 PMID: 26956358
Quick View
LY317615 (Enzastaurin)

Catalog No. A10356
Quick View

添加到收藏
PKCβ 抑制剂

LY317615（Enzastaurin）是一种有效的，选择性的PKCβ抑制剂，具有抗增殖活性（IC50 =?6 nM）。了解更多

Bulk Inquiry Free Sample
Quick View
VX-702

Catalog No. A10982
Quick View

添加到收藏
p38 MAPK 抑制剂

VX-702是一种高选择性p38α MAPK抑制剂，可抑制血小板激动剂诱导的p38激活（IC50 = 4至20 nM）。了解更多

Product Citations (1)

Bulk Inquiry Free Sample
- Wei-Chun HuangFu, etc. Inflammatory signaling compromises cell responses to interferon alpha. Oncogene. 2012 Jan 12; 31(2): 161–172.
Quick View
XAV 939

Catalog No. A10994
Quick View

添加到收藏
PARP 抑制剂

XAV 939是TNKS抑制剂（TNKS1和TNKS2的IC50值分别为0.011和0.004μM）。了解更多

Product Citations (2)

Bulk Inquiry Free Sample
- Shizu Aikawa, .et al. Autotaxin-lysophosphatidic acid-LPA 3 signaling at the embryo-epithelial boundary controls decidualization pathways, EMBO J, 2017, Jul 14; 36(14): 2146-2160 PMID: 28588064
- Mikaël M. Martino, .et al. Inhibition of IL-1R1/MyD88 signalling promotes mesenchymal stem cell-driven tissue regeneration, Nat Commun, 2016, 7: 11051 PMID: 27001940
Quick View
BMS-794833

Catalog No. A10154
Quick View

添加到收藏
c-Met 抑制剂

BMS-794833是Met和VEGFR-2的有效ATP竞争性抑制剂，IC50为1.7和15 nM。了解更多

Bulk Inquiry Free Sample
Quick View
AMG-458

Catalog No. A11055
Quick View

添加到收藏
c-Met 抑制剂

AMG-458是一种有效的c-Met抑制剂，IC50值为60nM，对VEGFR2具有选择性。了解更多

Bulk Inquiry Free Sample
Quick View
Ispinesib (SB-715992)

Catalog No. A10486
Quick View

添加到收藏
KSP 抑制剂

Ispinesib (SB-715992)是驱动蛋白纺锤体蛋白的有效抑制剂，驱动蛋白纺锤体蛋白是双极有丝分裂纺锤体形成和有丝分裂细胞周期进程所必需的驱动蛋白。了解更多

Bulk Inquiry Free Sample
Quick View
JNJ-26481585 (Quisinostat)

Catalog No. A10492
Quick View

添加到收藏
HDAC 抑制剂

JNJ-26481585 (Quisinostat)是一种pan-HDAC抑制剂，对HDAC1具有显著的效力(IC(50)，0.16 nmol/L)。了解更多

Product Citations (1)

Bulk Inquiry Free Sample
- Minoru Ueda, .et al. The Distinct Roles of Class I and II RPD3-Like Histone Deacetylases in Salinity Stress Response, Plant Physiol, 2017, Dec; 175(4): 1760-1773 PMID: 29018096
Quick View
S3I-201 (NSC 74859)

Catalog No. A10817
Quick View

添加到收藏
Stat3 抑制剂

S3I-201(NSC 74859)是Stat3的新型抑制剂，可在体外抑制Stat3，Stat3复合物的形成以及Stat3-DNA结合活性（IC50 = 86±33 ?M）和Stat3依赖性转录活性。了解更多

Product Citations (4)

Bulk Inquiry Free Sample
- Bae WJ, .et al. PTPRD-inactivation-induced CXCL8 promotes angiogenesis and metastasis in gastric cancer and is inhibited. J Exp Clin Cancer Res, 2019, 38:484 PMID: 31805999
- Nishimura K, .et al. Effect of erythropoietin production induced by hypoxia on autophagy in HepG2 cells, Biochem Biophys Res Commun, 2018, Jan 1;495(1):1317-1321 PMID: 29191652
- Ethan L. Morgan, .et al. STAT3 activation by E6 is essential for the differentiation-dependent HPV18 life cycle, PLoS Pathog, 2018, Apr; 14(4): e1006975 PMID: 29630659
- Soleimani AH, .et al. Micellar nano-carriers for the delivery of STAT3 dimerization inhibitors to melanoma, Drug Deliv Transl Res, 2017, Aug;7(4):571-581 PMID: 28290050
Quick View
VX-745

Catalog No. A10983
Quick View

添加到收藏
p38 MAPK 抑制剂

VX-745是一种有效的，选择性p38α抑制剂，IC50为10 nM，比作用于p38β选择性高22倍，对p38γ没有抑制作用。了解更多

Bulk Inquiry
Quick View
Linifanib (ABT-869)

Catalog No. A10025
Quick View

添加到收藏
VEGFR/PDGFR 抑制剂

Linifanib (ABT-869)是一种结构新颖的有效RTK，VEGF和PDGF抑制剂，对人内皮细胞，PDGFR-β，KDR和CSF-1R的IC50分别为0.2、2、4和7 nM。了解更多

Product Citations (1)

Bulk Inquiry
- Li Li, .et al. Evidence for activated Lck protein tyrosine kinase as the driver of proliferation in acute myeloid leukemia cell, CTV-1, Leukemia Res, 2019, 78:12-20 PMID: 30660961
Quick View
MLN2238 (Ixazomib)

Catalog No. A10600
Quick View

添加到收藏
Proteasome 抑制剂

MLN2238 (Ixazomib)是20S蛋白酶体抑制剂的有效可逆特异性β5位点，IC50值为3.4 nM。了解更多

Bulk Inquiry Free Sample
Quick View
Aloin (Barbaloin)

Catalog No. A10058
Quick View

添加到收藏
Tyrosinase 抑制剂

Aloin (Barbaloin)是一种从芦荟中得到的黄色结晶物质，据报道是酪氨酸酶的有效抑制剂。了解更多

Bulk Inquiry Free Sample
Quick View
Cidofovir (Vistide)

Catalog No. A10214
Quick View

添加到收藏
DNA/RNA Synthesis 抑制剂

Cidofovir (Vistide)通过选择性抑制病毒DNA的合成而抑制病毒复制。了解更多

Product Citations (1)

Bulk Inquiry Free Sample
- Adhikary A, .et al. π-Radical to σ-Radical Tautomerization in One-Electron-Oxidized 1-Methylcytosine and Its Analogs, J Phys Chem B, 2015, Sep 3;119(35):11496-505 PMID: 26237072

联系我们

Not your Region? View all Distributors

溶液配制计算器

分子量计算器

稀释计算器

摩尔浓度计算器

ADOOQ 产品质量保证

Guaranteed product quality, 365 days Unconditional Return & Replacement

We promise all products to perform as described.