你的浏览器似乎禁用了 JavaScript。
您必须在浏览器中启用JavaScript才能使用本网站的功能。

微信关注
申请试用装

主页 /
Products On Sale

Products On Sale

Quick View
Nimesulide

Catalog No. A11694
Quick View

添加到收藏
COX-2 抑制剂

Nimesulide是一种具有镇痛和解热特性的相对COX-2选择性，非甾体抗炎药（NSAID）。了解更多

Bulk Inquiry Free Sample
Quick View
Licofelone

Catalog No. A11697
Quick View

添加到收藏
COX/LOX 抑制剂

Licofelone是一种COX/LOX双重抑制剂，被认为是治疗骨关节炎的药物。它可能会降低与其他仅抑制COX（环氧合酶）的非甾体类抗炎药有关的胃肠道毒性。利福非酮是第一种同时抑制两者的药物。了解更多

Product Citations (1)

Bulk Inquiry Free Sample
- Silke Neumann, .et al. Improved Antitumor Activity of a Therapeutic Melanoma Vaccine through the Use of the Dual COX-2/5-LO Inhibitor Licofelone, Front Immunol, 2016, 7: 537 PMID: 27994586
Quick View
Brompheniramine

Catalog No. A11699
Quick View

添加到收藏
Brompheniramine是一种组胺H1受体拮抗剂。了解更多

Bulk Inquiry Free Sample
Quick View
Phenprocoumon

Catalog No. A10656
Quick View

添加到收藏
Phenprocoumon是一种维生素K拮抗剂，可通过阻止凝血因子II，VII，IX和X的合成来抑制凝血。它用于预防和治疗血栓栓塞性疾病（血栓形成/肺栓塞）。了解更多

Bulk Inquiry Free Sample
Quick View
Vanoxerine 2HCl (GBR-12909)

Catalog No. A10725
Quick View

添加到收藏
dopamine re-uptake 抑制剂

Vanoxerine 2HCl (GBR-12909)是哌嗪衍生物，是一种有效的、选择性的多巴胺摄取（dopamine uptake）抑制剂。了解更多

Bulk Inquiry Free Sample
Quick View
Acitazanolast

Catalog No. A10034
Quick View

添加到收藏
Acitazanolast是他扎诺司特和抗过敏药的活性代谢产物。了解更多

Bulk Inquiry Free Sample
Quick View
Dabrafenib (GSK2118436A)

Catalog No. A11381
Quick View

添加到收藏
Raf 抑制剂

Dabrafenib (GSK2118436A)是一种有效且选择性的B-RAF蛋白激酶抑制剂，具有V600E突变，目前正在临床试验中。了解更多

Product Citations (6)

Bulk Inquiry Free Sample
- Yuki Shimizu, .et al. Acquired resistance to BRAF inhibitors is mediated by BRAF splicing variants in BRAF V600E mutation-positive colorectal neuroendocrine carcinoma, Cancer Lett, 2022, Sep 1;543 PMID: 35724767
- Aya Hasan Alshammari, .et al. Discrimination of hand-foot skin reaction caused by tyrosine kinase inhibitors based on direct keratinocyte toxicity and vascular endothelial growth factor receptor-2 inhibition, Biochem Pharmacol, 2022, Mar;197:114914 PMID: 35041812
- Chenyang He, .et al. Detection of Dabrafenib using Optical Fibre Long Period Grating Sensor Modified with Surface Imprinted Polymers for Dose Detection and Prevention of Cancer Resistance, Clinical and Translational Biophotonics, 2020, TTh3B.2
- Hirosumi Tamura, .et al. Evaluation of anticancer agents using patient-derived tumor organoids characteristically similar to source tissues, Oncol Rep, 2018, Aug; 40(2): 635-646 PMID: 29917168
- Brittany M. Duggan, .et al. Tyrosine kinase inhibitors of Ripk2 attenuate bacterial cell wall-mediated lipolysis, inflammation and dysglycemia, Sci Rep, 2017, 7: 1578 PMID: 28484277
- Fujita KI, .et al. Involvement of the Transporters P-Glycoprotein and Breast Cancer Resistance Protein in Dermal Distribution of the Multikinase Inhibitor Regorafenib and Its Active Metabolites, J Pharm Sci, 2017, Sep;106(9):2632-2641 PMID: 28479358
Quick View
Cilnidipine

Catalog No. A10215
Quick View

添加到收藏
Calcium channel blocker

Cilnidipine是提供血管平滑肌中L型电压门控钙通道和交感神经末梢N型钙通道的双重阻滞剂。了解更多

Bulk Inquiry Free Sample
Quick View
Clemastine fumarate

Catalog No. A10226
Quick View

添加到收藏
Histamine Receptor antagonis

Clemastine fumarate是一种选择性的组胺H1拮抗剂。它与组胺H1受体结合，从而阻断了内源性组胺的作用，从而暂时缓解了由组胺引起的阴性症状。了解更多

Bulk Inquiry Free Sample
Quick View
Clomifene citrate

Catalog No. A10230
Quick View

添加到收藏
Clomifene citrate是一种选择性雌激素受体调节剂，用于诱导排卵。了解更多

Bulk Inquiry Free Sample
Quick View
Cortisone acetate

Catalog No. A10239
Quick View

添加到收藏
Cortisone acetate是Cortisone的乙酸盐形式，是甾体类激素，是一种糖皮质激素。了解更多

Bulk Inquiry Free Sample
Quick View
Crotamiton

Catalog No. A10243
Quick View

添加到收藏
Crotamiton是一种用作杀ab药（用于治疗sc疮）和一般止痒药（抗瘙痒药）的药物。了解更多

Product Citations (3)

Bulk Inquiry Free Sample
- Takashi Azuma, .et al. Removal of pharmaceuticals in water by introduction of ozonated microbubbles, SEP PURIF TECHNOL, 2019, Apr; 212: 483-489
- Azuma T, .et al. Distribution of six anticancer drugs and a variety of other pharmaceuticals, and their sorption onto sediments, in an urban Japanese river, Environ Sci Pollut Res Int, 2017, Aug;24(23):19021-19030 PMID: 28660504
- Azuma T, .et al. Detection of pharmaceuticals and phytochemicals together with their metabolites in hospital effluents in Japan, and their contribution to sewage treatment plant influents, Sci Total Environ, 2016, Apr 1;548-549:189-197 PMID: 26802347
Quick View
Crystal violet

Catalog No. A10245
Quick View

添加到收藏
Crystal violet是三芳基甲烷染料。该染料被用作组织学染色剂，并被用于革兰氏菌的分类方法。了解更多

Bulk Inquiry Free Sample
Quick View
Cyclosporin A

Catalog No. A10260
Quick View

添加到收藏
Cyclosporin A (Cyclosporine A)是一种免疫抑制剂，广泛用于异体后器官移植，以降低免疫系统的活性。了解更多

Product Citations (3)

Bulk Inquiry Free Sample
- X Jia, .et al. Arsenic Induces Hepatic Insulin Resistance via mtROS-NLRP3 Inflammasome Pathway, J Hazard Mater, 2020, Jun 4;399:123034 PMID: 32544768
- Y Huang, .et al. STIM1 controls calcineurin/Akt/mTOR/NFATC2?mediated osteoclastogenesis induced by RANKL/M?CSF, Experimental and Therapeutic Medicine, 2020, 20(2), 736-747
- Miyayama Y, .et al. Comparative study on the replication of HCV1b genome between wild type and cell culture adaptive mutant in regard to sensitivities against anti-HCV drugs, Microbiol Immunol, 2019, Dec 19 PMID: 31854467
Quick View
Vardenafil

Catalog No. A10965
Quick View

添加到收藏
PDE-5 抑制剂

Vardenafil是用于治疗勃起功能障碍的PDE5抑制剂。了解更多

Bulk Inquiry
Quick View
AZD2014 (Vistusertib)

Catalog No. A11303
Quick View

添加到收藏
mTORC1/2 抑制剂

Vistusertib (AZD2014)是一种新型mTOR抑制剂，无细胞试验中IC50为2.8 nM；对多种PI3K亚型(α/β/γ/δ)具有较高选择性。浓度为1 μM时，对大多数激酶无或有微弱结合力。了解更多

Product Citations (1)

Bulk Inquiry Free Sample
- Shuhang Dai, .et al. Calcium/calmodulin-dependent protein kinase kinase 2 mediates pleiotropic effects of epidermal growth factor in cancer cells, Biochim Biophys Acta Mol Cell Res, 2022, Jul;1869(7):119252 PMID: 35271909
Quick View
Istradefylline (KW-6002)

Catalog No. A11451
Quick View

添加到收藏
A2A 拮抗剂

Istradefylline (KW-6002)是A2A受体的选择性拮抗剂。了解更多

Product Citations (1)

Bulk Inquiry Free Sample
- PU Hamor, .et al. The Role of Glutamate mGlu5 and Adenosine A2a Receptor Interactions in Regulating Working Memory Performance and Persistent Cocaine Seeking in Rats, Prog Neuropsychopharmacol Biol Psychiatry, 2020, Dec 20;103:109979 PMID: 32470496
Quick View
Plerixafor 8HCl (DB06809)

Catalog No. A10913
Quick View

添加到收藏
CXCR4 拮抗剂

Plerixafor 8HCl (DB06809)是CXCR4趋化因子受体拮抗剂，作用于CXCR4和CXCL12介导调节的趋化性， IC50分别为44 nM和5.7 nM。了解更多

Product Citations (3)

Bulk Inquiry Free Sample
- Mei Zheng, .et al. CXCL12 inhibits hair growth through CXCR4, Biomed Pharmacother, 2022, Jun;150:112996 PMID: 35462338
- Asiedu KO, .et al. Bone marrow cell homing to sites of acute tibial fracture: 89Zr-oxine cell labeling with positron emission tomographic imaging in a mouse model, EJNMMI Res, 2018, Dec 13;8(1):109 PMID: 30547233
- Kingsley O. Asiedu, .et al. Bone marrow cell trafficking analyzed by 89Zr-oxine positron emission tomography in a murine transplantation model, Clin Cancer Res, 2017, Jun 1; 23(11): 2759-2768 PMID: 27965305
Quick View
Roflumilast

Catalog No. A10804
Quick View

添加到收藏
PDE 抑制剂

Roflumilast可作为PDE-4酶的选择性长效抑制剂，无细胞试验中IC50为0.2-4.3 nM。了解更多

Product Citations (2)

Bulk Inquiry Free Sample
- Zhongyuan Zhang, .et al. Roflumilast, a type of phosphodiesterase 4 inhibitor, can reduce intestinal injury caused by sepsis, Exp Ther Med, 2021, Dec;22(6):1398 PMID: 34650646
- Bing Zhong, .et al. Roflumilast Reduced the IL-18-Induced Inflammatory Response in Fibroblast-Like Synoviocytes (FLS), ACS Omega, 2021, Jan 26; 6(3): 2149-2155 PMID: 33521454
Quick View
Tyrphostin AG 879

Catalog No. A10053
Quick View

添加到收藏
HER2 抑制剂

Tyrphostin AG 879是神经生长因子（NGF）TrkA酪氨酸激酶活性的抑制剂。了解更多

Bulk Inquiry
Quick View
PF 4708671

Catalog No. A11755
Quick View

添加到收藏
S6 kinase 抑制剂

PF 4708671是p70核糖体S6激酶（S6K1）的高度特异性抑制剂，可抑制S6K1介导的IGF-1磷酸化S6蛋白的磷酸化，而对高度相关的RSK和MSK激酶没有影响。了解更多

Product Citations (1)

Bulk Inquiry Free Sample
- Nogami A, .et al. Inhibition of the STAT5/Pim Kinase Axis Enhances Cytotoxic Effects of Proteasome Inhibitors on FLT3-ITD-Positive AML Cells by Cooperatively Inhibiting the mTORC1/4EBP1/S6K/Mcl-1 Pathway, Transl Oncol, 2018, Nov 22;12(2):336-349 PMID: 30472492
Quick View
Isradipine

Catalog No. A10487
Quick View

添加到收藏
calcium channel blocker

伊拉地平是二氢吡啶类钙通道阻滞剂。了解更多

Product Citations (1)

Bulk Inquiry Free Sample
- Deborah A. Goldspink, .et al. Mechanistic insights into the detection of free fatty and bile acids by ileal glucagon-like peptide-1 secreting cells, Mol Metab, 2018, Jan; 7: 90-101 PMID: 29167062
Quick View
Tigecycline

Catalog No. A10933
Quick View

添加到收藏
Tigecycline具有抑菌作用，是一种蛋白质合成抑制剂，可与细菌的30S核糖体亚基结合，从而在原核翻译过程中阻止氨酰tRNA进入核糖体的A位点。了解更多

Product Citations (5)

Bulk Inquiry Free Sample
- Zewen Wen, .et al. In vitro activity and adaptation strategies of eravacycline in clinical Enterococcus faecium isolates from China, J Antibiot (Tokyo), 2022, Sep;75(9):498-508 PMID: 35896611
- Xiaoming Liu, .et al. Comparison of antibacterial activities and resistance mechanisms of omadacycline and tigecycline against Enterococcus faecium, J Antibiot (Tokyo), 2022, Aug;75(8):463-471 PMID: 35760902
- Sato T, .et al. Tigecycline Susceptibility of Klebsiella pneumoniae Complex and Escherichia coli Isolates from Companion Animals: The Prevalence of Tigecycline-Nonsusceptible K. pneumoniae Complex, Including Internationally Expanding Human Pathogenic Lineages, Microb Drug Resist, 2018, Jul/Aug;24(6):860-867 PMID: 29232167
- Dinah B. Aziz, .et al. Teicoplanin ?C Tigecycline Combination Shows Synergy Against Mycobacterium abscessus, Front Microbiol, 2018, May 11 PMID: 29867841
- Toyotaka Sato, .et al. Tigecycline Nonsusceptibility Occurs Exclusively in Fluoroquinolone-Resistant Escherichia coli Clinical Isolates, Including the Major Multidrug-Resistant Lineages O25b:H4-ST131-H30R and O1-ST648, Antimicrob Agents Chemother, 2017, Feb; 61(2): e01654-16 PMID: 27855067
Quick View
Bardoxolone methyl (RTA 402)

Catalog No. A11323
Quick View

添加到收藏
IκB/IKK 抑制剂

Bardoxolone甲基是口服的一流的合成三萜类化合物。它是Nrf2途径的诱导剂，可以抑制氧化应激和炎症。了解更多

Product Citations (4)

Bulk Inquiry
- Nakamura S, .et al. Nrf2 Activator RS9 Suppresses Pathological Ocular Angiogenesis and Hyperpermeability, Invest Ophthalmol Vis Sci, 2019, 60: 1943-1952
- Hisamichi M, .et al. Role of bardoxolone methyl, a nuclear factor erythroid 2-related factor 2 activator, in aldosterone- and salt-induced renal injury, Hypertens Res, 2018, Jan;41(1):8-17 PMID: 28978980
- Takahiko Imai, .et al. Nrf2 activator ameliorates hemorrhagic transformation in focal cerebral ischemia under anticoagulation, Neurobiol Dis, 2016, May;89:136-46 PMID: 26850917
- Takagi T, .et al. Temporal activation of Nrf2 in the penumbra and Nrf2 activator-mediated neuroprotection in ischemia-reperfusion injury., Free Radic Biol Med., 2014, 72:124-33 PMID: 24746614
Quick View
BYL719 (Alpelisib)

Catalog No. A11328
Quick View

添加到收藏
PI3K 抑制剂

BYL719 (Alpelisib)是一种口服生物可利用的磷脂酰肌醇3-激酶(PI3K)抑制剂，抑制 p110α/p110γ/p110δ/p110β 的 IC50 分别为 5 nM，250 nM，290 nM，1200 nM 。具有潜在的抗肿瘤活性。了解更多

Product Citations (3)

Bulk Inquiry Free Sample
- Lisann Pelzl, .et al. Antibody-mediated procoagulant platelet formation in COVID-19 is AKT dependent, J Thromb Haemost, 2022, Feb;20(2):387-398 PMID: 34752677
- J Wei, .et al. Profiling the surface proteome identifies actionable biology for TSC1 mutant cells beyond mTORC1 signaling, bioRxiv, 2018, 2018
- Pridham KJ, .et al. PIK3CB/p110β is a selective survival factor for glioblastoma, Neuro Oncol, 2018, Mar 27;20(4):494-505 PMID: 29016844
Quick View
SYN-115 (Tozadenant)

Catalog No. A11560
Quick View

添加到收藏
A2a receptor 拮抗剂

SYN115是口服，有效和选择性的腺苷2a（A2a）受体抑制剂，作用于人类和恒河猴的 adenosine A2A 受体，Ki 值分别为 11.5 nM 和 6 nM。了解更多

Bulk Inquiry Free Sample
Quick View
Duloxetine

Catalog No. A11705
Quick View

添加到收藏
Duloxetine是5-羟色胺-去甲肾上腺素再摄取抑制剂(SNRI)。它对重度抑郁症和广泛性焦虑症(GAD)有效。了解更多

Bulk Inquiry Free Sample
Quick View
Rivastigmine tartrate

Catalog No. A11719
Quick View

添加到收藏
AChE 抑制剂

Rivastigmine tartrate是一种双重胆碱酯酶抑制剂(ChEI)。它同时抑制丁酰胆碱酯酶(BChE)和乙酰胆碱酯酶(AChE)。了解更多

Bulk Inquiry Free Sample
Quick View
Brinzolamide

Catalog No. A11765
Quick View

添加到收藏
Carbonic anhydrase 抑制剂

Brinzolamide是一种碳酸酐酶抑制剂，IC50为3.19 nM。了解更多

Bulk Inquiry Free Sample
Quick View
BAY 80-6946 (Copanlisib)

Catalog No. A11766
Quick View

添加到收藏
PI3K 抑制剂

BAY 80-6946 (Copanlisib)是具有潜在抗肿瘤活性的磷酸肌醇3激酶（PI3K）抑制剂。了解更多

Product Citations (1)

Bulk Inquiry Free Sample
- Shin SM, .et al. Direct targeting of oncogenic RAS mutants with a tumor-specific cytosol-penetrating antibody inhibits RAS mutant-driven tumor growth, Sci Adv, 2020, Jan 15;6(3):eaay2174 PMID: 31998840
Quick View
Prucalopride

Catalog No. A11771
Quick View

添加到收藏
5-HT Receptor 激动剂

Prucalopride是一种选择性的，高亲和力的5-HT4受体激动剂，作用于5-HT4A和5-HT4B受体，Ki分别为2.5 nM和8 nM，比作用于5-HT受体亚型选择性高290倍以上。了解更多

Product Citations (1)

Bulk Inquiry Free Sample
- Pierre Meschin, .et al. p11 modulates calcium handling through 5-HT4R pathway in rat ventricular cardiomyocytes., Cell Calcium, 2015, Dec;58(6):549-57 PMID: 26427584
Quick View
Aciclovir (Acyclovir)

Catalog No. A10037
Quick View

添加到收藏
Aciclovir (Acyclovir)是一种合成的核苷类似物，有效作用于疱疹病毒。了解更多

Product Citations (3)

Bulk Inquiry Free Sample
- Takashi Azuma, .et al. Removal of pharmaceuticals in water by introduction of ozonated microbubbles, SEP PURIF TECHNOL, 2019, Apr; 212: 483-489
- Azuma T, .et al. Distribution of six anticancer drugs and a variety of other pharmaceuticals, and their sorption onto sediments, in an urban Japanese river, Environ Sci Pollut Res Int, 2017, Aug;24(23):19021-19030 PMID: 28660504
- Azuma T, .et al. Detection of pharmaceuticals and phytochemicals together with their metabolites in hospital effluents in Japan, and their contribution to sewage treatment plant influents, Sci Total Environ, 2016, Apr 1;548-549:189-197 PMID: 26802347
Quick View
Finasteride

Catalog No. A10387
Quick View

添加到收藏
Finasteride是合成的II型5α-还原酶抑制剂。该酶将睾丸激素转化为二氢睾丸激素(DHT)。了解更多

Product Citations (1)

Bulk Inquiry Free Sample
- Chen CC, .et al. The Genomic Alterations of 5α-Reductases and Their Inhibitor Finasteride-s Effect in Bladder Cancer, Anticancer Res, 2017, Dec;37(12):6893-6898 PMID: 29187470
Quick View
Lapatinib (free base)

Catalog No. A11752
Quick View

添加到收藏
Lapatinib (free base)是一种双重酪氨酸激酶抑制剂，是一种有效的EGFR和ErbB2抑制剂，在无细胞试验中IC50分别为10.2和9.8 nM。可阻断HER2生长受体途径。了解更多

Product Citations (7)

Bulk Inquiry Free Sample
- Aya Hasan Alshammari, .et al. Discrimination of hand-foot skin reaction caused by tyrosine kinase inhibitors based on direct keratinocyte toxicity and vascular endothelial growth factor receptor-2 inhibition, Biochem Pharmacol, 2022, Mar;197:114914 PMID: 35041812
- Hamzehlou S, .et al. Anti-tumor activity of neratinib, a pan-HER inhibitor, in gastric adenocarcinoma cells, Eur J Pharmacol, 2019, Nov 15;863:172705 PMID: 31574259
- Momeny M, .et al. The ERBB receptor inhibitor dacomitinib suppresses proliferation and invasion of pancreatic ductal adenocarcinoma cells, Cell Oncol (Dordr), 2019, Apr 25 PMID: 31025257
- Tzeng SF, .et al. O-Glycosylation-mediated signaling circuit drives metastatic castration-resistant prostate cancer, FASEB J, 2018, Jun 15:fj201800687 PMID: 29906246
- Fujita KI, .et al. Involvement of the Transporters P-Glycoprotein and Breast Cancer Resistance Protein in Dermal Distribution of the Multikinase Inhibitor Regorafenib and Its Active Metabolites, J Pharm Sci, 2017, Sep;106(9):2632-2641 PMID: 28479358
- Yuki Kawasaki, .et al. Feedback control of ErbB2 via ERK-mediated phosphorylation of a conserved threonine in the juxtamembrane domain, Sci Rep, 2016, 6: 31502 PMID: 27531070
- Tetsuya Saita, .et al. Preparation of Antibodies and Development of an Enzyme-Linked Immunosorbent Assay for the Tyrosine Kinase Inhibitors Lapatinib and Nilotinib., Biol Pharm Bull. , 2015, 38(10):1652-7 PMID: 26424026
Quick View
Argatroban

Catalog No. A11774
Quick View

添加到收藏
Thrombin 抑制剂

Argatroban是一种抗凝剂，是一种小分子直接凝血酶抑制剂，Ki值范围为5 nM-39 nM。了解更多

Bulk Inquiry Free Sample
Quick View
Azilsartan (TAK-536)

Catalog No. A11775
Quick View

添加到收藏
AT1 Receptor Blocker

Azilsartan (TAK-536)是一种用于治疗高血压的血管紧张素II受体拮抗剂。了解更多

Bulk Inquiry Free Sample
Quick View
LY2811376

Catalog No. A11776
Quick View

添加到收藏
BACE1 抑制剂

LY2811376是第一种可口服的非肽类BACE1抑制剂，可在动物体内产生显着的Aβ降低作用。了解更多

Bulk Inquiry Free Sample
Quick View
GSK 1210151A (I-BET151)

Catalog No. A11783
Quick View

添加到收藏
BET Bromodomain 抑制剂

GSK 1210151A (I-BET151)是溴结构域和额外末端（BET）家族蛋白BRD2，BRD3和BRD4的新型选择性抑制剂。了解更多

Product Citations (1)

Bulk Inquiry Free Sample
- Momeny M, .et al. Inhibition of bromodomain and extraterminal domain reduces growth and invasive characteristics of chemoresistant ovarian carcinoma cells, Anticancer Drugs, 2018, Nov;29(10):1011-1020 PMID: 30096128
Quick View
GSK2636771

Catalog No. A11784
Quick View

添加到收藏
PI3K 抑制剂

GSK2636771是一种有效的口服生物可用的PI3Kβ选择性抑制剂。了解更多

Product Citations (1)

Bulk Inquiry Free Sample
- Pridham KJ, .et al. PIK3CB/p110β is a selective survival factor for glioblastoma, Neuro Oncol, 2018, Mar 27;20(4):494-505 PMID: 29016844
Quick View
LX 1606 (Telotristat)

Catalog No. A11785
Quick View

添加到收藏
Serotonin synthesis 抑制剂

LX 1606 (Telotristat)是一种口服生物可利用的小分子色氨酸羟化酶（TPH）抑制剂，具有潜在的抗血清素活性。了解更多

Bulk Inquiry Free Sample
Quick View
CPI-613 (Devimistat)

Catalog No. A11786
Quick View

添加到收藏
Dehydrogenase 抑制剂

CPI-613是合成的α-硫辛酸硫辛酸类似物的对映异构体的外消旋混合物，具有潜在的化学预防和抗肿瘤活性。了解更多

Product Citations (2)

Bulk Inquiry Free Sample
- Takuji Sakuratani, .et al. Downregulation of ARID1A in gastric cancer cells: a putative protective molecular mechanism against the Harakiri-mediated apoptosis pathway, Virchows Arch, 2020, Aug 13 PMID: 32789692
- Egawa Y, .et al. Therapeutic potential of CPI-613 for targeting tumorous mitochondrial energy metabolism and inhibiting autophagy in clear cell sarcoma, PLoS One, 2018, Jun 7;13(6):e0198940 PMID: 29879220
Quick View
Aminopterin

Catalog No. A11787
Quick View

添加到收藏
Aminopterin是一种抗肿瘤药。它通过竞争二氢叶酸还原酶的叶酸结合位点而充当酶抑制剂。了解更多

Product Citations (1)

Bulk Inquiry Free Sample
- Nobuo Aikawa, .et al. A Novel Screening Test to Predict the Developmental Toxicity of Drugs Using Human Induced Pluripotent Stem Cells, J Toxicol Sci, 2020, 45(4):187-199 PMID: 32238694
Quick View
Avibactam

Catalog No. A11299
Quick View

添加到收藏
β-lactamase 抑制剂

Avibactam是一种共价，可逆的非β-内酰胺β-内酰胺酶抑制剂。了解更多

Product Citations (3)

Bulk Inquiry Free Sample
- Moonsuk Bae, .et al. In Vitro Activities of Ceftazidime-Avibactam and Aztreonam-Avibactam at Different Inoculum Sizes of Extended-Spectrum β-Lactam-Resistant Enterobacterales Blood Isolates, Antibiotics (Basel), 2021, Dec 5;10(12):1492 PMID: 34943704
- Taeeun Kim, .et al. In Vitro Activities and Inoculum Effects of Ceftazidime-Avibactam and Aztreonam-Avibactam against Carbapenem-Resistant Enterobacterales Isolates from South Korea, Antibiotics (Basel), 2020, Dec 15;9(12):912 PMID: 33334045
- Annelien Everaert, .et al. Effect of β-Lactamase inhibitors on in vitro activity of β-Lactam antibiotics against Burkholderia cepacia complex species, Antimicrob Resist Infect Control, 2016, 5: 44 PMID: 27895902
Quick View
ASC-J9

Catalog No. A11300
Quick View

添加到收藏
ASC-J9通过降解全长和剪接变体雄激素受体来抑制去势抵抗性前列腺癌的生长。了解更多

Product Citations (1)

Bulk Inquiry Free Sample
- Ruibao Chen, .et al. AR Pathway Is Involved in the Regulation of CX43 in Prostate Cancer, Biomed Res Int., 2015, 2015: 514234 PMID: 26491675
Quick View
AMD 070

Catalog No. A11315
Quick View

添加到收藏
CXCR4 拮抗剂

AMD 070是CXCR4趋化因子受体拮抗剂。了解更多

Product Citations (2)

Bulk Inquiry Free Sample
- Uchida D, .et al. Effect of a novel orally bioavailable CXCR4 inhibitor, AMD070, on the metastasis of oral cancer cells, Oncol Rep, 2018, Jul;40(1):303-308 PMID: 29749473
- Mamoru Morimoto, .et al. Enhancement of the CXCL12/CXCR4 axis due to acquisition of resistance in pancreatic cancer: effect of CXCR4 antagonists, BMC Cancer, 2016, 16: 305 PMID: 27175473
Quick View
BAY 61-3606

Catalog No. A11320
Quick View

添加到收藏
Syk 抑制剂

BAY 61-3606是一种细胞可渗透的咪唑并嘧啶化合物，可作为Syk酪氨酸激酶活性的有效，ATP竞争性，可逆和高度选择性抑制剂，而对Btk，Fyn，Itk，Lyn和Src无抑制作用。了解更多

Product Citations (3)

Bulk Inquiry Free Sample
- Ju-Won Jang, .et al. Spleen tyrosine kinase regulates crosstalk of hypoxia-inducible factor-1α and nuclear factor (erythroid-derived2)-like 2 for B cell survival, Int Immunopharmacol, 2021, Mar 21;95:107509 PMID: 33761438
- Sojin Park, .et al. BAFF attenuates oxidative stress-induced cell death by the regulation of mitochondria membrane potential via Syk activation in WiL2-NS B lymphoblasts, Sci Rep, 2020, 10: 11784 PMID: 32678160
- Park S, .et al. Spleen tyrosine kinase-dependent Nrf2 activation regulates oxidative stress-induced cell death in WiL2-NS human B lymphoblasts, Free Radic Res, 2018, Sep 11:1-11 PMID: 30203714
Quick View
Baricitinib (LY3009104)

Catalog No. A11329
Quick View

添加到收藏
JAK 抑制剂

Baricitinib，也称为INCB028050或LY3009104，是一种选择性口服可生物利用的JAK1/JAK2抑制剂，对JAK1（5.9 nM）和JAK2（5.7 nM）具有纳摩尔浓度。了解更多

Product Citations (2)

Bulk Inquiry Free Sample
- Yuki Sasaki, .et al. Blockade of the CXCR3/CXCL10 axis ameliorates inflammation caused by immunoproteasome dysfunction, JCI Insight, 2022, Apr 8;7(7) PMID: 35393946
- Yutian Lei, .et al. A multicenter blinded preclinical randomized controlled trial on Jak1/2 inhibition in MRL/MpJ-Fas lpr mice with proliferative lupus nephritis predicts low effect size, Kidney Int, 2021, Feb 16 PMID: 33607177
Quick View
Boceprevir (SCH-503034)

Catalog No. A11332
Quick View

添加到收藏
HCV Protease 抑制剂

Boceprevir (SCH-503034)是一种蛋白酶抑制剂，可用于治疗C型肝炎基因型1。了解更多

Product Citations (2)

Bulk Inquiry Free Sample
- Ueda Y, .et al. Evaluation of preclinical antimalarial drugs, which can overcome direct-acting antivirals-resistant hepatitis C viruses, using the viral reporter assay systems, Virus Res, 2017, May 2;235:37-48 PMID: 28322919
- Shirasaki T, .et al. Impaired interferon signaling in chronic hepatitis C patients with advanced fibrosis via the transforming growth factor beta signaling pathway., Hepatology., 2014, 60(5):1519-30 PMID: 24962339
Quick View
BIBX 1382

Catalog No. A11334
Quick View

添加到收藏
EGFR 抑制剂

BIBX 1382是一种细胞可渗透的嘧啶嘧啶化合物，可作为一种有效的，可逆的，ATP竞争性高选择性的EGFR抑制剂。了解更多

Bulk Inquiry Free Sample
Quick View
Alosetron

Catalog No. A11310
Quick View

添加到收藏
5-HT3 拮抗剂

Alosetron是一种5-HT3拮抗剂，对胃肠道肠道神经系统的5-HT3受体具有拮抗作用。了解更多

Bulk Inquiry Free Sample

联系我们

Not your Region? View all Distributors

溶液配制计算器

分子量计算器

稀释计算器

摩尔浓度计算器

ADOOQ 产品质量保证

Guaranteed product quality, 365 days Unconditional Return & Replacement

We promise all products to perform as described.