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PROTAC Bcl2 degrader-1 (Compound C5) is a PROTAC, which potently and selectively induces the degradation of Bcl-2 (IC50, 4.94 μM; DC50, 3.0 μM) and Mcl-1 (IC50, 11.81 μM) by introducing the E3 ligase cereblon (CRBN)-binding ligand pomalidomide to Mcl-1/Bcl-2 dual inhibitor Nap-1.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 10.62 mL | 53.09 mL | 106.18 mL |
| 0.5 mM | 2.12 mL | 10.62 mL | 21.24 mL |
| 1 mM | 1.06 mL | 5.31 mL | 10.62 mL |
| 5 mM | 0.21 mL | 1.06 mL | 2.12 mL |
*The above data is based on the productmolecular weight 941.84. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A18355 |
|---|---|
| 作用机制 | Degrader (降解剂) |
| M. Wt | 941.84 |
| Formula | C45H45BrN6O10S |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 2378801-85-3 |
| SMILES | O=C(NCCOCCOCCNC1=CC=CC(C(N2C3CCC(NC3=O)=O)=O)=C1C2=O)CCCCC(NCCN4C(C5=C6C(C4=O)=CC=C(C6=CC=C5)SC7=CC=C(C=C7)Br)=O)=O |
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