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PROTAC Bcl2 degrader-1

目录号: A18355

degrader

PROTAC Bcl2 degrader-1

PROTAC Bcl2 degrader-1 Chemical Structure

CAS NO. 2378801-85-3

PROTAC Bcl2 degrader-1 (Compound C5) is a PROTAC, which potently and selectively induces the degradation of Bcl-2 (IC50, 4.94 μM; DC50, 3.0 μM) and Mcl-1 (IC50, 11.81 μM) by introducing the E3 ligase cereblon (CRBN)-binding ligand pomalidomide to Mcl-1/Bcl-2 dual inhibitor Nap-1.

库存： 现货

规格 价格 数量
5 mg
￥ 2,450.00
10 mg
￥ 4,550.00
50 mg
￥ 14,700.00
或
Warning 产品仅用于科学研究，不针对患者销售，望谅解.
产品详情

生物活性

PROTAC Bcl2 degrader-1 (Compound C5) is a PROTAC, which potently and selectively induces the degradation of Bcl-2 (IC50, 4.94 μM; DC50, 3.0 μM) and Mcl-1 (IC50, 11.81 μM) by introducing the E3 ligase cereblon (CRBN)-binding ligand pomalidomide to Mcl-1/Bcl-2 dual inhibitor Nap-1.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 10.62 mL 53.09 mL 106.18 mL
0.5 mM 2.12 mL 10.62 mL 21.24 mL
1 mM 1.06 mL 5.31 mL 10.62 mL
5 mM 0.21 mL 1.06 mL 2.12 mL

*The above data is based on the productmolecular weight 941.84. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号 A18355
作用机制 Degrader (降解剂)
M. Wt 941.84
Formula C45H45BrN6O10S
Purity >99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No. 2378801-85-3
SMILES O=C(NCCOCCOCCNC1=CC=CC(C(N2C3CCC(NC3=O)=O)=O)=C1C2=O)CCCCC(NCCN4C(C5=C6C(C4=O)=CC=C(C6=CC=C5)SC7=CC=C(C=C7)Br)=O)=O

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